Synthesis and Evaluation of Coumarin–Resveratrol Hybrids as 15-Lipoxygenaze Inhibitors

<div><p></p><p>A series of coumarin–resveratrol hybrids, 3-arylcoumarin derivatives <b>3a–u</b>, were synthesized through the intermolecular condensation reaction of various salicylaldehydes and phenylacetic acids in the presence of 1,4-diazabicyclo[2.2.2]octane under solvent-free conditions. All the synthesized compounds were screened for their inhibitory potency against soybean 15-lipoxygenase. Among them, three compounds (<b>3c</b>, <b>3j</b>, and <b>3q</b>) showed good enzyme-inhibitory activities.</p></div