Traditional Media and Social Media: An Approach

If we talk about the relationship between the society and the media, it emerges that this relationship has always been one of loyalty. Media is a powerful medium for the promotion and dissemination of social aspects or activities. Media network is playing a major role in the dissemination of information. The medium of development and communication has given the form of media to every citizen of the society. With the change of time, this form is now visible in front of the society in the form of social media. As far as the question of social media websites, Facebook, Twitter and Instagram is concerned, these apps have played an important role in it. In the research paper, along with the change from media to social media, both its positive and negative aspects have been highlighted

Institutional Structure of Cotton Research in India

The chapter traces the landmark events in the contemporary history of cotton in India. The achievements in research and development that transformed India from a chronic importer of cotton to the largest producer and a net exporter of cotton are highlighted. The structure of cotton research undertaken by the institutes under the National Agricultural Research and Education System (NARES) are also elaborated. The institutional mechanism responsible for varietal release, seed production and transfer of technology are briefly described. The immediate challenges facing the cotton sector and approaches to tackle them are also discussed

Laparoscopic management of giant ovarian cyst in young woman: a case report

Giant ovarian cysts are very rare nowadays and were conventionally treated by full midline laparotomy. In recent years, the laparoscopic approach is also practiced but it needs a lot of expertise and only a few cases have been reported. As the surgical treatment of choice has become less invasive, laparoscopic surgery is considered more beneficial over laparotomy because of better cosmetic results, less blood loss, reduced postoperative analgesic requirement, early mobilization and faster discharge from the hospital and early resumption to normal day to day activity. We report a case of laparoscopic extirpation of a giant right ovarian cyst measuring 15 × 21 × 22 cm in young 24-year female

Monocrotophos Induced Apoptosis in PC12 Cells: Role of Xenobiotic Metabolizing Cytochrome P450s

Monocrotophos (MCP) is a widely used organophosphate (OP) pesticide. We studied apoptotic changes and their correlation with expression of selected cytochrome P450s (CYPs) in PC12 cells exposed to MCP. A significant induction in reactive oxygen species (ROS) and decrease in glutathione (GSH) levels were observed in cells exposed to MCP. Following the exposure of PC12 cells to MCP (10−5 M), the levels of protein and mRNA expressions of caspase-3/9, Bax, Bcl2, P53, P21, GSTP1-1 were significantly upregulated, whereas the levels of Bclw, Mcl1 were downregulated. A significant induction in the expression of CYP1A1/1A2, 2B1/2B2, 2E1 was also observed in PC12 cells exposed to MCP (10−5 M), whereas induction of CYPs was insignificant in cells exposed to 10−6 M concentration of MCP. We believe that this is the first report showing altered expressions of selected CYPs in MCP-induced apoptosis in PC12 cells. These apoptotic changes were mitochondria mediated and regulated by caspase cascade. Our data confirm the involvement of specific CYPs in MCP-induced apoptosis in PC12 cells and also identifies possible cellular and molecular mechanisms of organophosphate pesticide-induced apoptosis in neuronal cells

Protocol of systematic reviews on implementation research on cardiovascular diseases, diabetes mellitus and mental ailments in India [version 2; peer review: 2 approved]

Introduction The burden of non-communicable diseases (NCDs) is a major public health concern across the world. Various initiatives have tried to address these with varying degrees of success. Objective The objective is to assess and collate existing evidence in implementation research done in India on three broad domains of NCDs namely, cardiovascular diseases (CVD), diabetes mellitus (DM), and mental health (MH) in India. Materials and methods Three systematic review protocols have been drafted to explore and collate extant evidence of implementation research on cardiovascular diseases, diabetes mellitus, and mental health in India, in accordance with the PRISMA-P statement. Academic databases including PubMed, Embase and Science Direct will be searched. Search strategies will be formulated in iterative processes and in accordance with the formats that are specific to the databases that will be searched. In addition, grey literature and non-academic databases will also be explored. Data extracted from the selected studies will be analysed and a narrative summary of the selected articles, using the SWiM (Synthesis without meta-analysis) guidelines will be produced. Intended Outcomes The outputs of these systematic reviews could help in a better understanding of implementation research gaps and also how to address them. Apart from giving insights into how healthcare initiatives for CVDs, diabetes and mental health could be implemented in a better way, the study could also advocate the need to build and consolidate capacity for implementation research in the country