149 research outputs found
Transverse NMR relaxation as a probe of mesoscopic structure
Transverse NMR relaxation in a macroscopic sample is shown to be extremely
sensitive to the structure of mesoscopic magnetic susceptibility variations.
Such a sensitivity is proposed as a novel kind of contrast in the NMR
measurements. For suspensions of arbitrary shaped paramagnetic objects, the
transverse relaxation is found in the case of a small dephasing effect of an
individual object. Strong relaxation rate dependence on the objects' shape
agrees with experiments on whole blood. Demonstrated structure sensitivity is a
generic effect that arises in NMR relaxation in porous media, biological
systems, as well as in kinetics of diffusion limited reactions.Comment: 4 pages, 3 figure
Fatty liver in familial hypobetalipoproteinemia: Triglyceride assembly into VLDL particles is affected by the extent of hepatic steatosis
Familial hypobetalipoproteinemia (FHBL) subjects may develop fatty liver. Liver fat was assessed in 21 FHBL with six different apolipoprotein B (apoB) truncations (apoB-4 to apoB-89) and 14 controls by magnetic resonance spectroscopy (MRS). Liver fat percentages were 16.7 ± 11.5 and 3.3 ± 2.9 (mean ± SD) (P = 0.001). Liver fat percentage was positively correlated with body mass index, waist circumference, and areas under the insulin curves of 2 h glucose tolerance tests, suggesting that obesity may affect the severity of liver fat accumulation in both groups. Despite 5-fold differences in liver fat percentage, mean values for obesity and insulin indexes were similar. Thus, for similar degrees of obesity, FHBL subjects have more hepatic fat. VLDL-triglyceride (TG)-fatty acids arise from plasma and nonplasma sources (liver and splanchnic tissues). To assess the relative contributions of each, [2H2] palmitate was infused over 12 h in 13 FHBL subjects and 11 controls. Isotopic enrichment of plasma free palmitate and VLDL-TG-palmitate was determined by mass spectrometry. Nonplasma sources contributed 51 ± 15% in FHBL and 37 ± 13% in controls (P = 0.02). Correlations of liver fat percentage and percent VLDL-TG-palmitate from liver were r = 0.89 (P = 0.0001) for FHBL subjects and r = 0.69 (P = 0.01) for controls. Thus, apoB truncation-producing mutations result in fatty liver and in altered assembly of VLDL-TG
Evidence for adult lung growth in humans
A 33-year-old woman underwent a right-sided pneumonectomy in 1995 for treatment of a lung adenocarcinoma. As expected, there was an abrupt decrease in her vital capacity, but unexpectedly, it increased during the subsequent 15 years. Serial computed tomographic (CT) scans showed progressive enlargement of the remaining left lung and an increase in tissue density. Magnetic resonance imaging (MRI) with the use of hyperpolarized helium-3 gas showed overall acinar-airway dimensions that were consistent with an increase in the alveolar number rather than the enlargement of existing alveoli, but the alveoli in the growing lung were shallower than in normal lungs. This study provides evidence that new lung growth can occur in an adult human
'Theory for the enhanced induced magnetization in coupled magnetic trilayers in the presence of spin fluctuations'
Motivated by recent experiments, the effect of the interlayer exchange
interaction on the magnetic properties of coupled Co/Cu/Ni
trilayers is studied theoretically. Here the Ni film has a lower Curie
temperature than the Co film in case of decoupled layers. We
show that by taking into account magnetic fluctuations the interlayer coupling
induces a strong magnetization for T\gtsim T_{C,\rm Ni} in the Ni film. For
an increasing the resonance-like peak of the longitudinal Ni
susceptibility is shifted to larger temperatures, whereas its maximum value
decreases strongly. A decreasing Ni film thickness enhances the induced Ni
magnetization for T\gtsim T_{C,\rm Ni}. The measurements cannot be explained
properly by a mean field estimate, which yields a ten times smaller effect.
Thus, the observed magnetic properties indicate the strong effect of 2D
magnetic fluctuations in these layered magnetic systems. The calculations are
performed with the help of a Heisenberg Hamiltonian and a Green's function
approach.Comment: 4 pages, 3 figure
In-plane dipole coupling anisotropy of a square ferromagnetic Heisenberg monolayer
In this study we calculate the dipole-coupling-induced quartic in-plane
anisotropy of a square ferromagnetic Heisenberg monolayer. This anisotropy
increases with an increasing temperature, reaching its maximum value close to
the Curie temperature of the system. At T=0 the system is isotropic, besides a
small remaining anisotropy due to the zero-point motion of quantum mechanical
spins. The reason for the dipole-coupling-induced anisotropy is the disturbance
of the square spin lattice due to thermal fluctuations ('order-by-disorder'
effect). For usual ferromagnets its strength is small as compared to other
anisotropic contributions, and decreases by application of an external magnetic
field. The results are obtained from a Heisenberg Hamiltonian by application of
a mean field approach for a spin cluster, as well as from a many-body Green's
function theory within the Tyablikov-decoupling (RPA).Comment: 6 pages, 2 figures, accepted for publication in RP
Anisotropic susceptibility of ferromagnetic ultrathin Co films on vicinal Cu
We measure the magnetic susceptibility of ultrathin Co films with an in-plane
uniaxial magnetic anisotropy grown on a vicinal Cu substrate. Above the Curie
temperature the influence of the magnetic anisotropy can be investigated by
means of the parallel and transverse susceptibilities along the easy and hard
axes. By comparison with a theoretical analysis of the susceptibilities we
determine the isotropic exchange interaction and the magnetic anisotropy. These
calculations are performed in the framework of a Heisenberg model by means of a
many-body Green's function method, since collective magnetic excitations are
very important in two-dimensional magnets.Comment: 7 pages, 3 figure
Перспективы развития автоматизированных обучающих систем для теоретической подготовки персонала гражданской авиации
The article is devoted to the automated educational systems as means of theoretical education of civil aircraft personnel. The author considers different types of AES, handles the problem of actuality of such systems today and of the necessity of their development and possible availability.Статья посвящена автоматизированным обучающим системам как средствам теоретической подготовки авиационного персонала ГА. Автор рассматривает различные виды АОС, поднимаются вопросы об актуальности подобных систем сегодня, необходимости их дальнейшего развития и возможных перспективах
Results of surgical treatment of glial tumors of functionally important areas with intraoperative mapping of the pyramidal tract
The article is devoted to the analysis of the surgical treatment of patients with a glial tumor of functionally important areas of the brain operated on in the SOOD from 2007 to 2020 using the intraoperative mapping technique.Статья посвящена анализу хирургического лечения пациентов с глиальной опухолью функционально важных зон головного мозга, прооперированных в ГБУЗ СООД с 2007 по 2020 год, с использованием методики интраоперационного картирования
Adenosine-regulated mechanisms in the pathogenesis of ventilation disorders in patients with pulmonary tuberculosis
Uncovering involvement of the purinergic system in the pathogenesis of ventilation disorders (VD) may provide additional information about the pathophysiological mechanisms leading to the development of VD in pulmonary tuberculosis (PT). The aim was to identify a relationship between the parameters of adenosine metabolism, inflammatory response and altered ventilation metabolism in PT patients. Materials and methods. Obstructive and mixed PT patients were assigned to subgroups with/without VD for assessing adenosine deaminase activity (ADA-1, 2) in serum, mononuclear cells, neutrophils; ecto-5’-nucleotidase (ecto-5’-NT); CD26 (dipeptidyl peptidase-4, DPP-4), phagocyte oxidative burst measured by NO generation. Results. PT patients showed decreased ADA-1 and CD26 (DPP-4), but increased ADA-2. Elevated intracellular adenosine concentration was found in mononuclear cells in patients lacking VD, whereas patients with mixed and obstructive VD — had it in neutrophils. Mononuclear cells of patients with PT lacking VD as well as with obstructive VD type had decreased NO3– concentration. Neutrophil hyperactivity was recorded in all groups of PT patients. Patients with PT lacking VD as well as with mixed VD type showed that the parameters of external respiration were associated with activity of extra-/intracellular ADA, whereas obstructive VD was caused by excessive formation of serum adenosine. Changes in respiratory function in PT were associated with decreased level of serum NO radicals, impaired nitrogen-dependent bactericidal phagocyte activity, and overproduced neutrophil oxygen radicals. Conclusion. Purinergic regulation is involved in regulating inflammatory and compensatory processes in PT patients as well as impaired ventilation efficiency. The most severe respiratory disorders observed in PT patients with mixed VD type are associated with the most prominent changes in nucleotidase activity, particularly ecto-ADA-2 and DPP-4/CD26
NITRIC OXIDE – BIOCHEMICAL MARKER OF TUBERCULOSIS PATHOGENESIS
Role of nitric oxide in the pathogenesis of pulmonary tuberculosis has been studied in 77 patients with new infiltrate pulmonary tuberculosis and 34 patients with fibrous cavernous pulmonary tuberculosis. The level of cumulative and endogenous nitrite depended on the clinical form of tuberculosis: in infiltrate pulmonary tuberculosis patients it was within the limits of reference ranges, and in fibrous cavernous pulmonary tuberculosis patients it was significantly lower. Results of statistical analysis point out at the significant homogeneity (monofunctionality) of the set of rates, defining the level of NO metabolites in blood serum in infiltrate pulmonary tuberculosis, namely: impact of adenosine deaminase, levels of α1-protease inhibitor, ceruleoplasmin and age. On the contrary in case of fibrous cavernous pulmonary tuberculosis the diverse (multi-functional) complexes were detected including clinical blood rates providing influence on the reduction of NO level in blood. Nitric oxide in the patients with both clinical forms of tuberculosis correlated with classical markers of system inflammatory response, thus nitric oxide can be regarded as an integral component of inflammatory response with potential evaluation of prognosis of specific lesions during follow-up of changes
- …