ИНФОРМАЦИОННАЯ СРЕДА ДЛЯ ВЫСОКОПРОИЗВОДИТЕЛЬНЫХ МЕДИКО-БИОЛОГИЧЕСКИХ ВЫЧИСЛЕНИЙ

This work represented one of the possible approaches to providing the required computational resources for solving the complex data processing tasks in biomedicine. The proposed solution is based on four tightly interacted key components of modern high performance computational systems: high perfor­mance computational cluster, data processing center, specialized data store and protected telecommunication channels. The examples of tasks, which have been solved in the developed information environment, are given.В работе представлен один из возможных подходов к обеспечению экспериментальных и клинических медико-биологических исследований необходимыми вычислительными ресурсами для решения сложных задач обработки биомедицинских данных. Предложенное решение основано на тесном взаимодействии четырех ключевых компонентов современных высокопроизводительных вычислительных комплексов: высокопроизводительного суперкомпьютерного кластера, центра обработки данных, специализированного хранилища данных и защищенных телекоммуникационных каналов. Приведены примеры работ, выполненных с использованием разработанной информационной среды

Apoptosis of skeletal and cardiac muscles and physical exercise

Aging (Milano). 1997 Feb-Apr;9(1-2):19-34. Apoptosis of skeletal and cardiac muscles and physical exercise. Carraro U, Franceschi C. Source C.N.R. Unit for Muscle Biology and Physiopathology, Department of Biomedical Sciences, University of Padova, Italy. Abstract Besides the well-known reciprocal influences of skeletal muscle and heart during and after physical exercise, a new perspective is emerging on the short- and long-term effects of exercise-induced damage, in particular the pathogenic role of inappropriate apoptosis in skeletal and cardiac muscle. Cells from multicellular organisms self-destruct when they are no longer needed, or have become damaged; they do this by activating a genetically controlled cell suicide machinery that leads to programmed cell death (PCD), or apoptosis. Apoptosis is a specific form of programmed cell death that plays an important role in development, growth regulation and disease. Skeletal muscles in adult animals are fully differentiated syncytial cells. Apoptosis, which is known to be present in tissues that modulate their cellular homeostasis under the influence of growth and/or hormonal factors, has been recently described in early stages of myocardial infarct, and in dystrophic skeletal muscle. The role and the cellular and molecular aspects of muscle cell death and apoptosis are far from clear, particularly following several types of muscle damage (genetic defects, exercise-induced damage, oxidative stress, etc.). It can be predicted that apoptosis plays a major role in regulating myoblast proliferation during muscle regeneration, and in the progression of dystrophinopathies. A particularly important area has recently developed concerning cardiac muscle and reperfusion injury after ischemia; in this case as well, a major role of apoptosis is emerging. PMID: 9177583 [PubMed - indexed for MEDLINE