Sensing With Random Signals

Radar systems typically employ well-designed deterministic signals for target sensing. In contrast to that, integrated sensing and communications (ISAC) systems have to use random signals to convey useful information, potentially causing sensing performance degradation. This paper analyzes the sensing performance via random ISAC signals over a multi-antenna system. Towards this end, we define a new sensing performance metric, namely, ergodic linear minimum mean square error (ELMMSE), which characterizes the estimation error averaged over the randomness of ISAC signals. Then, we investigate a data-dependent precoding scheme to minimize the ELMMSE, which attains the {optimized} sensing performance at the price of high computational complexity. To reduce the complexity, we present an alternative data-independent precoding scheme and propose a stochastic gradient projection (SGP) algorithm for ELMMSE minimization, which can be trained offline by locally generated signal samples. Finally, we demonstrate the superiority of the proposed methods by simulations.Comment: 6 pages, 5 figures, submitted to ICASSP 202

Random ISAC Signals Deserve Dedicated Precoding

Radar systems typically employ well-designed deterministic signals for target sensing, while integrated sensing and communications (ISAC) systems have to adopt random signals to convey useful information. This paper analyzes the sensing and ISAC performance relying on random signaling in a multi-antenna system. Towards this end, we define a new sensing performance metric, namely, ergodic linear minimum mean square error (ELMMSE), which characterizes the estimation error averaged over random ISAC signals. Then, we investigate a data-dependent precoding (DDP) scheme to minimize the ELMMSE in sensing-only scenarios, which attains the optimized performance at the cost of high implementation overhead. To reduce the cost, we present an alternative data-independent precoding (DIP) scheme by stochastic gradient projection (SGP). Moreover, we shed light on the optimal structures of both sensing-only DDP and DIP precoders. As a further step, we extend the proposed DDP and DIP approaches to ISAC scenarios, which are solved via a tailored penalty-based alternating optimization algorithm. Our numerical results demonstrate that the proposed DDP and DIP methods achieve substantial performance gains over conventional ISAC signaling schemes that treat the signal sample covariance matrix as deterministic, which proves that random ISAC signals deserve dedicated precoding designs.Comment: 15 pages, 12 figure

Multi-color nonreciprocal optical amplifier with spinning active optomechanics

We propose to achieve a multi-color nonreciprocal optical amplifier, a crucial device in optical communication and information processing, by spinning an active resonator. We show that in such a device, due to the interplay of the Sagnac effect and the optical gain, nonreciprocal signal {amplification} can be realized, accompanied by a giant enhancement of optical group delay from $0.3\;\mathrm{ms}$ to $35\;\mathrm{ms}$ in a chosen direction, which is otherwise unattainable in a passive device. Also, coherent amplification of higher-order optical sidebands and a slow-to-fast light switch can be achieved by tuning both the pump power and the spinning velocity. Our work provides a unique and accessible way, well-compatible with other existing techniques, to realize multi-color nonreciprocal optical amplifiers for more flexible control of optical fields.Comment: 8pages, 4 figure

Expanded CURB-65: A new score system predicts severity of community-acquired pneumonia with superior efficiency

Aim of this study was to develop a new simpler and more effective severity score for communityacquired pneumonia (CAP) patients. A total of 1640 consecutive hospitalized CAP patients in Second Affiliated Hospital of Zhejiang University were included. The effectiveness of different pneumonia severity scores to predict mortality was compared, and the performance of the new score was validated on an external cohort of 1164 patients with pneumonia admitted to a teaching hospital in Italy. Using age≥ 65 years, LDH>230u/L, albumin<3.5g/dL, platelet count<100×109/L, confusion, urea>7mmol/L, respiratory rate≥30/min, low blood pressure, we assembled a new severity score named as expanded-CURB-65. The 30-day mortality and length of stay were increased along with increased risk score. The AUCs in the prediction of 30-day mortality in the main cohort were 0.826 (95%CI, 0.807–0.844), 0.801 (95%CI, 0.781–0.820), 0.756 (95%CI, 0.735–0.777), 0.793 (95%CI, 0.773–0.813) and 0.759 (95%CI, 0.737–0.779) for the expanded-CURB-65, PSI, CURB-65, SMART-COP and A-DROP, respectively. The performance of this bedside score was confirmed in CAP patients of the validation cohort although calibration was not successful in patients with health care-associated pneumonia (HCAP). The expanded CURB-65 is objective, simpler and more accurate scoring system for evaluation of CAP severity, and the predictive efficiency was better than other score systems

Tripartite quantum entanglement with squeezed optomechanics

The ability to engineer entangled states that involve macroscopic objects is of particular importance for a wide variety of quantum-enabled technologies, ranging from quantum information processing to quantum sensing. Here we propose how to achieve coherent manipulation and enhancement of quantum entanglement in a hybrid optomechanical system, which consists of a Fabry-P\'{e}rot cavity with two movable mirrors, an optical parametric amplifier (OPA), and an injected squeezed vacuum reservoir. We show that the advantages of this system are twofold: (i) one can effectively regulate the light-mirror interactions by introducing a squeezed intracavity mode via the OPA; (ii) when properly matching the squeezing parameters between the squeezed cavity mode and the injected squeezed vacuum reservoir, the optical input noises can be suppressed completely. These peculiar features of this system allow us to generate and manipulate quantum entanglement in a coherent and controllable way. More importantly, we also find that such controllable entanglement, under some specific squeezing parameters, can be considerably enhanced in comparison with those of the conventional optomechanical system. Our work, providing a promising method to regulate and tailor the light-mirror interaction, are poised to serve as a useful tool for engineering various quantum effects which are based on cavity optomechanics.Comment: 11 pages, 3 figure

Tacrolimus (Tacro) strongly inhibits intestinal UDP-glucuronosyltransferase (UGT) 1A8

Tacrolimus (Brand name: Prograf), a kind of immunosuppressants, has been reported to induce drug-drug interaction with many clinical drugs. Tacrolimus-mycophenolic acid (MPA) interaction has been widely and frequently reported. Intestinal UDP-glucuronosyltransferase (UGT) 1A8-mediated metabolism plays a key role in the elimination of MPA, and alteration of the activity of UGT1A8 resulting from gene polymorphisms could significantly influence the catalyzing activity of MPA glucuronidation. The aim of the present study is to investigate the inhibitory potential of tacrolimus towards UGT1A8, which was speculated to be a potential cause for tacrolimus-MPA interaction. The recombinant UGT1A8 was used as enzyme source, and a nonspecific substrate 4-methylumbelliferone (4-MU) was utilized as substrate. The results showed that 100 μM of tacrolimus inhibited UGT1A8-mediated 4-MU glucuronidation activity by 82.3%. Further inhibition kinetic investigation showed that the inhibition of UGT1A8 by tacrolimus was best fit to competitive inhibition type, and the inhibition kinetic parameter (Ki) was determined to be 6.1 μM. All these results indicated that tacrolimus could exhibit strong inhibition towards UGT1A8, which should be paid more attention when explaining clinical tacrolimus-MPA interaction.Colegio de Farmacéuticos de la Provincia de Buenos Aire

The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey.

BACKGROUND: The seasonal influenza vaccine coverage rate in China is only 1.9 %. There is no information available on the economic burden of influenza-associated outpatient visits and hospitalizations at the national level, even though this kind of information is important for informing national-level immunization policy decision-making. METHODS: A retrospective telephone survey was conducted in 2013/14 to estimate the direct and indirect costs of seasonal influenza-associated outpatient visits and hospitalizations from a societal perspective. Study participants were laboratory-confirmed cases registered in the National Influenza-like Illness Surveillance Network and Severe Acute Respiratory Infections Sentinel Surveillance Network in China in 2013. Patient-reported costs from the survey were validated by a review of hospital accounts for a small sample of the inpatients. RESULTS: The study enrolled 529 outpatients (median age: eight years; interquartile range [IQR]: five to 20 years) and 254 inpatients (median age: four years; IQR: two to seven years). Among the outpatients, 22.1 % (117/529) had underlying diseases and among the inpatients, 52.8 % (134/254) had underlying diseases. The average total costs related to influenza-associated outpatient visits and inpatient visits were US$155 (standard deviation, SD US$ 122) and US$1,511 (SD US$ 1,465), respectively. Direct medical costs accounted for 45 and 69 % of the total costs related to influenza-associated outpatient and inpatient visits, respectively. For influenza outpatients, the mean cost per episode in children aged below five years (US$196) was higher than that in other age groups (US$ 129-153). For influenza inpatients, the mean cost per episode in adults aged over 60 years (US$2,735) was much higher than that in those aged below 60 years (US$ 1,417-1,621). Patients with underlying medical conditions had higher costs per episode than patients without underlying medical conditions (outpatients: US$186 vs. US$ 146; inpatients: US$1,800 vs. US$ 1,189). In the baseline analysis, inpatients reported costs were 18 % higher than those found in the accounts review (n = 38). CONCLUSION: The economic burden of influenza-associated outpatient and inpatient visits in China is substantial, particularly for young children, the elderly, and patients with underlying medical conditions. More widespread influenza vaccination would likely alleviate the economic burden of patients. The actual impact and cost-effectiveness analysis of the influenza immunization program in China merits further investigation