Dynamical tunneling-assisted coupling of high-Q deformed microcavities using a free-space beam

We investigate the efficient free-space excitation of high-Q resonance modes in deformed microcavities via dynamical tunneling-assisted coupling. A quantum scattering theory is employed to study the free-space transmission properties, and it is found that the transmission includes the contribution from (1) the off-resonance background and (2) the on-resonance modulation, corresponding to the absence and presence of high-Q modes, respectively. The theory predicts asymmetric Fano-like resonances around high-Q modes in background transmission spectra, which are in good agreement with our recent experimental results. Dynamical tunneling across Kolmogorov-Arnold-Moser tori, which plays an essential role in the Fano-like resonance, is further studied. This efficient free-space coupling holds potential advantages to simplify experimental conditions and excite high-Q modes in higher-index-material microcavities

Prognostic and clinicopathological significance of fatty acid synthase in breast cancer: A systematic review and meta-analysis

BackgroundAberrant expression of fatty acid synthase (FASN) was demonstrated in various tumors including breast cancer. A meta-analysis was conducted to investigate the role of FASN in breast cancer development and its potential prognostic significance.MethodsThe Web of Science, PubMed, Embase, and Cochrane Library databases were searched to identify studies that evaluated the relationship between FASN expression and overall survival (OS), relapse-free survival (RFS), and disease-free survival (DFS) of breast cancer patients. To analyze the clinicopathological and prognostic values of FASN expression in breast cancer, pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were clustered based on random-effects models. To confirm whether the findings were stable and impartial, a sensitivity analysis was performed, and publication bias was estimated. Data were analyzed using Engauge Digitizer version 5.4 and Stata version 15.0.ResultsFive studies involving 855 participants were included. Patients with higher FASN expression did not have a shorter survival period compared to those with lower FASN expression (summary HR: OS, 0.73 [95% CI, 0.41-1.32; P=0.300]; DFS/RFS, 1.65 [95% CI, 0.61-4.43; P=0.323]). However, increased FASN expression was correlated with large tumor size (OR, 2.04; 95% CI, 1.04-4.00; P=0.038), higher human epidermal growth factor receptor 2 (HER2) positivity (OR, 1.53; 95% CI, 1.05-2.23; P=0.028). No significant associations were observed between FASN expression and histological grade (OR, 0.92; 95% CI, 0.41-2.04; P=0.832), Tumor Node Metastasis (TNM) stage (OR, 1.11; 95% CI, 0.49-2.53; P=0.795), nodal metastasis (OR, 1.42; 95% CI, 0.84-2.38; P=0.183), Ki-67 labelling index (OR, 0.64; 95% CI, 0.15-2.63; P=0.533), estrogen receptor (ER) status (OR, 0.90; 95% CI, 0.61-1.32; P=0.586), or progesterone receptor (PR) status (OR, 0.67; 95% CI, 0.29-1.56; P=0.354).ConclusionFASN is associated with HER2 expression and may contribute to tumor growth, but it has no significant impact on the overall prognosis of breast cancer

Hydro(solvo)thermal construction of a copper coordination polymer involving in situ ligand synthesis: Preparation and Structure of [Cu-3(bdcO)(2)(H2O)(2)](n)

A hydro(solvo)thermal reaction of 1,3-benzenedicarboxylic acid (bdcH(2)) and CuSO4.5H(2)O produced a coordination polymer [Cu-3(bdcO)(2)(H2O)(2)](n) 1. The alkoxyl-1,3-benzene-dicarboxylate trianion (bdcO(3-)) found in the final product was in situ generated by the hydroxylation of bdcH(2) during the synthesis. Its crystal structure has been determined by X-ray structural analysis. The complex belongs to a monoclinic system, space group P2(1)/c with C16H10Cu3O12, M-r = 584.86, a = 5.0349(3), b = 10.422(1), c = 15.639(1) angstrom, beta = 91.977(2)degrees, V = 820.1(1) angstrom(3), Z = 2, D-c= 2.368 g/cm(3), mu = 3.931 mm(-1), lambda(MoK alpha) = 0.71073 angstrom, F(OOO) = 578, the final R = 0.0328 and wR = 0.0742 for 1730 observed reflections with 1 >=,2 sigma(I). The copper atoms show different coordination environments. Each bdcO group is binds to three copper atoms through oxygen atoms of carboxylates and deprononated hydroxy group in bridging and chelating fashions, affording a copper atom coordinated by two [Cu-2(bdcO)(2)](2-), matallo-ligand' to yield an extending zigzagged layer perpendicular to the c axis