3 research outputs found
ΠΡΠΎΡΠΈΡΠ½ΡΠΉ Π°ΠΌΠΈΠ»ΠΎΠΈΠ΄ΠΎΠ· Ρ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π»Π΅Π³ΠΊΠΈΡ Ρ Π±ΠΎΠ»ΡΠ½ΠΎΠΉ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΡΠΌ Π°ΡΡΡΠΈΡΠΎΠΌ
The paper considers the problem of secondary amyloidosis that more frequently occurs in patients with various arthritides, both seropositive and seronegative. According to the data available in the literature, the most common manifestations of secondary amyloidosis are involvements of the kidney, liver, nervous system, and, less frequently, the lung. The authors describe their own observation of secondary amyloidosis in rheumatoid arthritis, which is accompanied by the involvement of the lung, kidney, and intestine, resulting in fatal outcome. The lifetime diagnosis of amyloidosis was histologically verified.Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ° Π²ΡΠΎΡΠΈΡΠ½ΠΎΠ³ΠΎ Π°ΠΌΠΈΠ»ΠΎΠΈΠ΄ΠΎΠ·Π°, ΠΊΠΎΡΠΎΡΡΠΉ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΠ°ΡΠ΅ Π²ΡΡΡΠ΅ΡΠ°Π΅ΡΡΡ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ Π°ΡΡΡΠΈΡΠ°ΠΌΠΈ, ΠΊΠ°ΠΊ ΡΠ΅ΡΠΎΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΡΠΌΠΈ, ΡΠ°ΠΊ ΠΈ ΡΠ΅ΡΠΎΠ½Π΅Π³Π°ΡΠΈΠ²Π½ΡΠΌΠΈ. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΡΠΌΠΈ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΠΌΠΈ Π²ΡΠΎΡΠΈΡΠ½ΠΎΠ³ΠΎ Π°ΠΌΠΈΠ»ΠΎΠΈΠ΄ΠΎΠ·Π°, ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ, ΡΠ²Π»ΡΡΡΡΡ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΏΠΎΡΠ΅ΠΊ, ΠΏΠ΅ΡΠ΅Π½ΠΈ, Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, ΡΠ΅ΠΆΠ΅ - Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π»Π΅Π³ΠΊΠΈΡ
. ΠΠ²ΡΠΎΡΡ ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π²ΡΠΎΡΠΈΡΠ½ΠΎΠ³ΠΎ Π°ΠΌΠΈΠ»ΠΎΠΈΠ΄ΠΎΠ·Π° ΠΏΡΠΈ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΠΎΠΌ Π°ΡΡΡΠΈΡΠ΅, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π²ΡΠ΅Π³ΠΎΡΡ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π»Π΅Π³ΠΊΠΈΡ
, ΠΏΠΎΡΠ΅ΠΊ ΠΈ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ°, Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΡΡ
ΠΎΠ΄Π°. ΠΠΈΠ°Π³Π½ΠΎΠ· Π°ΠΌΠΈΠ»ΠΎΠΈΠ΄ΠΎΠ·Π° Π±ΡΠ» ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΠΏΡΠΈΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎ
SECONDARY AMYLOIDOSIS WITH LUNG INVOLVEMENT INA FEMALE PATIENT WITH RHEUMATOID ARTHRITIS
The paper considers the problem of secondary amyloidosis that more frequently occurs in patients with various arthritides, both seropositive and seronegative. According to the data available in the literature, the most common manifestations of secondary amyloidosis are involvements of the kidney, liver, nervous system, and, less frequently, the lung. The authors describe their own observation of secondary amyloidosis in rheumatoid arthritis, which is accompanied by the involvement of the lung, kidney, and intestine, resulting in fatal outcome. The lifetime diagnosis of amyloidosis was histologically verified
ROLE OF MULTIPLEX CYTOKINE ANALYSIS IN THE EVALUATION OF THE EFFICACY OF RITUXIMAB DURING TREATMENT FOR RHEUMATOID ARTHRITIS
Along with its basic activity in removing B-lymphocytes, rituximab (RTM) causes depletion of a population of CD20+ T cells that can pro- duce a variety of immunoregulatory and proinflammatory cytokines and chemokines. Objective: to define a role of multiplex cytokine analysis in the evaluation of the efficiency of using RMT in rheumatoid arthritis (RA). Subjects and methods. Thirty-four patients with the valid diagnosis of RA according to the ACR criteria of 1987 were examined. The con- centrations of cytokines were measured using the xMAP technology (27-plex). Results and discussion. In the group of patients with a clinical response to therapy with the gene engineering biological agent, there was a decrease in the concentrations of interleukins (IL) 1Ξ², 1ra, 2, 4, 6, 9, and 13, granulocyte macrophage colony-stimulating factor (GM- CSF), Ξ³-interferon (IFN-Ξ³), monocyte chemoattractant 1 at week 8 of therapy; that in IL 1Ξ², 1ra, 2, 5, 6, 9, 10, 12, 13, and 15, fibroblast growth factor 2 (FGF-2), GM-CSF, IFN-Ξ³, and tumor necrosis factor-Ξ± at week 24, and that in IL-9 at week 40. The no-clinical response group showed a reduction in GM-CSF at week 8 and in IL-2 and macrophage inflammatory protein 1Ξ² (MIP-1Ξ²) at week 40, and an increase in IL-8 at week 8. At week 8 after drug infusion, the elevated levels of IL-17 and MIP-1Ξ² can be identified as possible early pre- dictors of a response (at week 40). Comparison of the baseline cytokine levels in the groups with different clinical response demonstrated a more than three-fold increase in the concentrations of IL 4, 5, 7, 8, 10, 12, 13, 15, 17, IFN-Ξ³, and vascular endothelial growth factor, and IL-8 at weeks 8 and 40, respectively