COMPARATIVE STUDY OF EFFECT OF CHAIN YOGIC EXERCISE (YOGASANA) AND YOGIC THERAPY (AGNISAR KRIYA) FOR REHABILITATION OF TYPE 2 DIABETES MELLITUS (T2D)

The motive of this study was to find out the effect of Chain Yogic Exercise (Yogasana), Yogic Therapy (Agnisar Kriya) on Diabetes Mellitus (T2D). For the purpose of this study 200 subjects were selected and divided into two groups from Delhi, India. Both groups are experimental groups. In each group, 100:100 Type 2 Diabetes Mellitus (T2DM) subjects were distributed. There were 50 females and 50 males in each group i.e. half of the each group was female. The subjects’ age ranged between 35-45 years. One group was engaged in Chain Yogic Exercise (Yogasana) and the other group was perform Yogic Therapy (Agnisar Kriya), This process was for 90 days (30-30-30 days). The data was collected on the first day (dated 16th September 2020) of 1st round as pre-test and on the last day (dated 16th October 2020) of 1st round as post-test. For statistical analysis and interpretation of data, paired t-Test was employed. The level of significance had been taken 0.05 and 0.01. The study found Chain Yogic Exercise (Yogasana), Yogic Therapy (Agnisar Kriya) both has a significant effect to control Diabetes Mellitus (T2D). The study also found that Yogic Therapy (Agnisar Kriya) had much better effect to control Diabetes Mellitus (T2D) than Chain Yogic Exercise (Yogasana). Article visualizations

A SURVEY ON OPPORTUNITY, SCOPE AND POSSIBILITIES OF YOGA INTERVENTION IN MODERN CHINA

The purpose of this study was to find out the scope, facilities and possibilities of Yoga intervention in China. For the purpose of this study, 201 samples i.e. yoga instructors (22); yoga studio owners (7); yoga instructors plus yoga studio owners (8) yoga practitioners (113) yoga lovers (50) and others (1) from various provinces and cities from China were randomly selected. The subjects’ age ranged between 60+ to 90+ years. To find out the scope, facilities and possibilities of Yoga intervention in China, a questionnaire made by “Vivekananda Cultural Communication (Shanghai) Co. Ltd.” based on “Daily Yoga Courses and Training Content in China” were introduced. For statistical analysis and interpretation of data, descriptive statistics of selected variables and descriptive statement analysis method were conducted. Interestingly this study found a very high level of scope, facilities and realistic possibilities of Yoga intervention in China which directly or indirectly might be help to develop yoga industries in China and also can better understand the need and interest of yoga for health and wellbeing among Chines population in new era.   Article visualizations

3,4-Bis(4-meth­oxy­phen­yl)-2,5-dihydro-1H-pyrrole-2,5-dione

In the title compound, C18H15NO4, the benzene rings form quite different dihedral angles [16.07 (1) and 59.50 (1)°] with the central pyrrole ring, indicating a twisted mol­ecule. Conjugation is indicated between the five- and six-membered rings by the lengths of the C—C bonds which link them [1.462 (3) and 1.477 (3) Å]. The most prominent feature of the crystal packing is the formation of inversion dimers via eight-membered {⋯HNCO}2 synthons

CQNV: A combination of coarsely quantized bitstream and neural vocoder for low rate speech coding

Recently, speech codecs based on neural networks have proven to perform better than traditional methods. However, redundancy in traditional parameter quantization is visible within the codec architecture of combining the traditional codec with the neural vocoder. In this paper, we propose a novel framework named CQNV, which combines the coarsely quantized parameters of a traditional parametric codec to reduce the bitrate with a neural vocoder to improve the quality of the decoded speech. Furthermore, we introduce a parameters processing module into the neural vocoder to enhance the application of the bitstream of traditional speech coding parameters to the neural vocoder, further improving the reconstructed speech's quality. In the experiments, both subjective and objective evaluations demonstrate the effectiveness of the proposed CQNV framework. Specifically, our proposed method can achieve higher quality reconstructed speech at 1.1 kbps than Lyra and Encodec at 3 kbps.Comment: Accepted by INTERSPEECH 202

Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK)

<p>Abstract</p> <p>Background</p> <p>Due to the widespread abusage of antibiotics, antibiotic-resistance in <it>Streptococcus pneumoniae </it>(<it>S. pneumoniae</it>) has been increasing quickly in recent years, and it is obviously urgent to develop new types of antibiotics. Two-component systems (TCSs) are the major signal transduction pathways in bacteria and have emerged as potential targets for antibacterial drugs. Among the 13 pairs of TCSs proteins presenting in <it>S. pneumoniae</it>, VicR/K is the unique one essential for bacterium growth, and block agents to which, if can be found, may be developed as effective antibiotics against <it>S. pneumoniae </it>infection.</p> <p>Results</p> <p>Using a structure-based virtual screening (SBVS) method, 105 compounds were computationally identified as potential inhibitors of the histidine kinase (HK) VicK protein from the compound library SPECS. Six of them were then validated <it>in vitro </it>to be active in inhibiting the growth of <it>S. pneumoniae </it>without obvious cytotoxicity to Vero cell. In mouse sepsis models, these compounds are still able to decrease the mortality of the mice infected by <it>S. pneumoniae </it>and one compound even has significant therapeutic effect.</p> <p>Conclusion</p> <p>To our knowledge, these compounds are the first reported inhibitors of HK with antibacterial activity <it>in vitro </it>and <it>in vivo</it>, and are novel lead structures for developing new drugs to combat pneumococcal infection.</p

Changes of Microorganisms and Flavor Compounds in the Fourth Round Jiupei of Sauce-flavored Baijiu in Beijing

Sauce-flavor Baijiu shows a typical sauce flavor, with a delicate mouthfeel. Its fermentation process consists of seven cycles, and each cycle produces one kind of base liquor. The fourth cycle liquor has a rich flavor and excellent quality. During the fermentation process, microorganisms are in a dynamic state, while flavor substances differ. This study investigated the microbial changes of Jiupei in the fourth cycle and their impact on flavor substances. Species diversity analysis was conducted on the fourth cycle Jiupei sample using high-throughput sequencing. Flavor substances were analyzed using headspace solid-phase microextraction combined with gas chromatography-mass spectrometry. Results showed that the dominant bacteria in the Jiupei were Lactobacillus, Virgibacillus, and Kroppenstedtia, while dominant fungi were Thermoascus, Aspergillus, and Issatchenkia. The microbial community in the Jiupei showed significant dynamic changes during the later stage of fermentation. The Jiupei showed the richest variety of alcohol and ester substances at the beginning of fermentation, with the relative content of alcohol, ester, and acid compounds showing a pattern of increasing firstly and then gradually decreased during fermentation. This study conducted a correlation analysis between fungi and bacteria at the genus level and flavor substances, revealing that Monascus, Lactobacillus, and Wickerhamomyces were positively correlated with key flavor substances, such as ethyl acetate, ethyl lactate, and ethyl hexanoate, respectively. The data provided a basis for comparing the microorganisms and flavor substances in the fourth cycle of sauce-flavor Baijiu, and offered a theoretical basis for improving the quality of Baijiu

SHP-2-induced M2 polarization of tumor associated macrophages via IL-4 regulate colorectal cancer progression

ObjectiveTo explore the effect and molecular mechanism of Src homology region 2 domain-containing protein tyrosine phosphatase-2 (SHP-2) in tumor-associated macrophages (TAMs) repressing the migration and invasion of colorectal cancer (CRC) cells.MethodsThe relevant data sets of human colon specimens were obtained from GEO database, and then the performed correlation analysis, principal component analysis and differentially expressed gene (DEGs) analysis on the samples were conducted. GO and KEGG enrichment analysis were performed on the common DEGs, and then functional interaction prediction was performed to verify the gene regulatory circuit of SHP-2. Furthermore, western blot was used to detect the effect of low expression of SHP-2 on related proteins, including the markers of promoting M2 polarization and exosome secretion, and keys proteins of the PI3K pathway. The relationship between SHP-2 and PI3K pathway was further verified by adding PI3K inhibitor LY294002. Finally, the effect of SHP-2 on the function of colon cancer cells was confirmed by wound healing assay and Transwell assay.ResultsThrough bioinformatics analysis, SHP-2 was screened as a possible key gene affecting CRC. The low expression of SHP-2 promoted the protein levels of Arginase-1 and IL-10 in IL-4 induced M2 macrophages, while inhibited the protein levels of IL-1β and TNF-α. Meanwhile, low expression of SHP-2 was found to similarly promote the expression of p-PI3K, p-AKT, and the release of exosomes. Interestingly, the promotion was suppressed after the addition of the PI3K inhibitor LY294002. In terms of cellular behavior, wound healing and transwell data showed that low expression of SHP-2 enhanced the migration and invasion abilities of CRC cells.ConclusionThe low expression of SHP-2 induced by PHPS1 may regulate M2 polarization of TAMs and release of exosomes through PI3K/AKT pathway, thereby enhancing the migration and invasion ability of CRC cells

学会抄録

Mauve visualization of local collinear blocks identified among 14 haplotypes (15BACs) from Saccharum species and sorghum. (DOCX 1909 kb

Genetic analysis and population structure of wild and cultivated wishbone flower (Torenia fournieri Lind.) lines related to specific floral color

Background The wishbone flower or Torenia fournieri Lind., an annual from tropical Indochina and southern China, is a popular ornamental plant, and many interspecific (T. fournieri × T. concolor) hybrid lines have been bred for the international market. The cultivated lines show a pattern of genetic similarity that correlates with floral color which informs on future breeding strategies. This study aimed to perform genetic analysis and population structure of cultivated hybrid lines comparing with closely related T. concolor wild populations. Methods We applied the retrotransposon based iPBS marker system for genotyping of a total of 136 accessions from 17 lines/populations of Torenia. These included 15 cultivated lines of three series: Duchess (A, B, C); Kauai (D, E, F, G, H, I, J); Little Kiss (K, L, M, N, P) and two wild T. concolor populations (Q and R). PCR products from each individual were applied to estimate the genetic diversity and differentiation between lines/populations. Results Genotyping results showed a pattern of genetic variation differentiating the 17 lines/populations characterized by their specific floral colors. The final PCoA analysis, phylogenetic tree construction, and Bayesian population structural bar plot all showed a clear subdivision of lines/populations analysed. The 15 cultivated hybrid lines and the wild population Q that collected from a small area showed the lowest genetic variability while the other wild population R which sampled from a larger area had the highest genetic variability. Discussion The extremely low genetic variability of 15 cultivated lines indicated that individual line has similar reduction in diversity/heterozygosity from a bottleneck event, and each retained a similar (but different from each other) content of the wild genetic diversity. The genetic variance for the two wild T. concolor populations could be due to our varied sampling methods. The two wild populations (Q, R) and the cultivated hybrid lines (I, K, M, N, P) are genetically more closely related, but strong positive correlations presented in cultivated lines A, C, E, M, and N. These results could be used to guide future Torenia breeding. Conclusions The genetic variation and population structure found in our study showed that cultivated hybrid lines had similar reduction in diversity/heterozygosity from a bottleneck event and each line retained a similar (but different from each other) content of the wild genetic diversity, especially when strong phenotypic selection of floral color overlaps. Generally, environmental factors could induce transposon activation and generate genetic variability which enabled the acceleration of the evolutionary process of wild Torenia species. Our study revealed that wild Torenia populations sampled from broad geographic region represent stronger species strength with outstanding genetic diversity, but selective breeding targeting a specific floral color decreased such genetic variability