9 research outputs found
Positive carbon isotope excursions: global correlation and genesis in the Middle–Upper Ordovician in the northern Tarim Basin, Northwest China
Farnesoid X Receptor Ligand Prevents Cisplatin-Induced Kidney Injury by Enhancing Small Heterodimer Partner
Triads in Equine-Assisted Social Work Enhance Therapeutic Relationships with Self-Harming Adolescents
Lessons from the Past: Sponges and the Geological Record
Sponges have been a major part of marine ecosystems, in both shallow and deep water, from the time of the earliest animal communities. The great shifts in climate that have occurred over the past 541 million years have affected all organisms, including sponges. Although patchy knowledge of the sponge fossil record hinders recognition of trends, some general patterns are apparent. Shallow-water siliceous sponges were severely affected by glacial intervals, whereas deeper-water siliceous sponges appear to have flourished during these times. Some groups of hypercalcified sponges (such as stromatoporoids) were abundant during times of global warming and high sea level, but other groups (archaeocyathans and sphinctozoans) had their acme during times of low sea level and relatively cool climate. Overall, sponge diversity appears to have been controlled more by sea level than by climate: large-scale sponge biotas occurred at times of high sea level, when there were large areas of shallow sea.Fil: Muir, Lucy. National Museum Wales; Reino UnidoFil: Botting, Joseph P.. National Museum Wales; Reino Unido. Nanjing Institute Of Geology And Palaeontology; ChinaFil: Beresi, Matilde Sylvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentin
Oligodendrocyte Fate after Spinal Cord Injury
Oligodendrocytes (OLs) are particularly susceptible to the toxicity of the acute lesion environment after spinal cord injury (SCI). They undergo both necrosis and apoptosis acutely, with apoptosis continuing at chronic time points. Loss of OLs causes demyelination and impairs axon function and survival. In parallel, a rapid and protracted OL progenitor cell proliferative response occurs, especially at the lesion borders. Proliferating and migrating OL progenitor cells differentiate into myelinating OLs, which remyelinate demyelinated axons starting at 2 weeks post-injury. The progression of OL lineage cells into mature OLs in the adult after injury recapitulates development to some degree, owing to the plethora of factors within the injury milieu. Although robust, this endogenous oligogenic response is insufficient against OL loss and demyelination. First, in this review we analyze the major spatial–temporal mechanisms of OL loss, replacement, and myelination, with the purpose of highlighting potential areas of intervention after SCI. We then discuss studies on OL protection and replacement. Growth factors have been used both to boost the endogenous progenitor response, and in conjunction with progenitor transplantation to facilitate survival and OL fate. Considerable progress has been made with embryonic stem cell-derived cells and adult neural progenitor cells. For therapies targeting oligogenesis to be successful, endogenous responses and the effects of the acute and chronic lesion environment on OL lineage cells must be understood in detail, and in relation, the optimal therapeutic window for such strategies must also be determined