Grain refinement of DC cast magnesium alloys with intensive melt shearing

A new direct chill (DC) casting process, melt conditioned DC (MC-DC) process, has been developed for the production of high quality billets/slabs of light alloys by application of intensive melt shearing through a rotor-stator high shear device during the DC casting process. The rotor-stator high shear device provides intensive melt shearing to disperse the naturally occurring oxide films, and other inclusions, while creating a microscopic flow pattern to homogenize the temperature and composition fields in the sump. In this paper, we report the grain refining effect of intensive melt shearing in the MC-DC casting processing. Experimental results on DC casting of Mg-alloys with and without intensive melt shearing have demonstrated that the MC-DC casting process can produce magnesium alloy billets with significantly refined microstructure. Such grain refinement in the MC-DC casting process can be attributed to enhanced heterogeneous nucleation by dispersed naturally occurring oxide particles, increased nuclei survival rate in uniform temperature and compositional fields in the sump, and potential contribution from dendrite arm fragmentation

Three-dimensional finite element analyses on the transtibial residual limb and its prosthetic socket

2000-2001 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Quantitative comparison of plantar foot shapes under different weight-bearing conditions

2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Human foot three-dimensional finite element of modeling and its biomechanical applications

2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

3D visualization and information interaction in biomedical applications

2001-2002 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Creación, re significación y uso de recursos simbólicos y discursivos durante el gobierno de Evo Morales (2006-2019)

Trabajo de conclusión de curso presentado al Instituto Latinoamericano de Economía, Sociedad y Política de la Universidad Federal de Integración Latino Americana, como requisito parcial para acceder a la Licenciatura en Relaciones Internacionales e Integración Orientador: Prof. Dra. Paula Daniela FernandezDurante los trece años de gobierno de Evo Morales (2006-2019) junto a su partido el Movimiento al Socialismo (MAS), se observan grandes contradicciones entre su discurso político de orden indigenista y sus prácticas políticas, algunas que se remiten a formas políticas de gobiernos tradicionales y de corte occidental. En este sentido se pueden apreciar sus herramientas simbólicas y discursivas, que por un lado toman la imagen de Morales como el único camino posible para el “proceso de cambio”, y otros que resignifican elementos del mundo indígena para ser incorporados al ideario del MAS. De este modo el objetivo de este trabajo es describir y analizar los recursos simbólicos y discursivos utilizados por el gobierno de Evo Morales y el MAS en el periodo 2006- 2019 a fin de legitimarse y consolidarse en el poder.Durante os treze anos de governo de Evo Morales (2006-2019) com seu partido, o Movimento ao Socialismo (MAS), existem grandes contradições entre seu discurso político de uma ordem indigenista e suas práticas políticas, algumas que se referem a formas políticas de governos tradicionais e ocidentais. Nesse sentido, podem ser apreciadas suas ferramentas simbólicas e discursivas, que por um lado tomam a imagem de Morales como o único caminho possível para o “processo de mudança” e outras que ressignificam elementos do mundo indígena a serem incorporados à ideologia do MAS. Assim, o objetivo deste trabalho é descrever e analisar os recursos simbólicos e discursivos utilizados pelo governo de Evo Morales e pelo MAS no período 2006-2019 para legitimar e consolidar no poder

Characterization of Fish IRF3 as an IFN-Inducible Protein Reveals Evolving Regulation of IFN Response in Vertebrates

In mammals, IFN regulatory factor (IRF) 3 is a critical player in modulating transcription of type I IFN and IFN-stimulated genes (ISGs). In this study, we describe the roles of crucian carp (Carassius auratus L.) IRF3 in activating fish IFN and ISGs. Fish IRF3 exhibits a large sequence divergence from mammalian orthologs. Whereas mammalian IRF3 is constitutively expressed, fish IRF3 protein is significantly upregulated by IFN, poly-IC, and other stimuli known as IFN inducers in mammals. The IFN-inducible property of fish IRF3 is consistent with the comparative analysis of 5' flanking regulatory region of vertebrate IRF3 genes, which reveals the presence of typical IFN-stimulated response elements in fish and amphibians, but an absence in tetrapods. Furthermore, either IFN or poly-IC induces phosphorylation and cytoplasmic-to-nuclear translocation of IRF3, which seems essential for its function in that phosphomimic active IRF3 exhibits stronger transactivation than wild type IRF3. Finally, overexpression of fish IRF3 activates production of IFN that in turn triggers ISG transcription through Stat1 pathway, whereas transfection of dominant negative mutant IRF3-DN abrogates poly-IC induction of ISGs, probably owing to blockade of IFN production. Therefore, regulation of IFN response by vertebrate IRF3 is another ancient trait. These data provide evidence of the evolving function of vertebrate IRF3 on regulating IFN response. The Journal of Immunology, 2010, 185: 7573-7582

Transport Spectroscopy of Symmetry-Broken Insulating States in Bilayer Graphene

The flat bands in bilayer graphene(BLG) are sensitive to electric fields E\bot directed between the layers, and magnify the electron-electron interaction effects, thus making BLG an attractive platform for new two-dimensional (2D) electron physics[1-5]. Theories[6-16] have suggested the possibility of a variety of interesting broken symmetry states, some characterized by spontaneous mass gaps, when the electron-density is at the carrier neutrality point (CNP). The theoretically proposed gaps[6,7,10] in bilayer graphene are analogous[17,18] to the masses generated by broken symmetries in particle physics and give rise to large momentum-space Berry curvatures[8,19] accompanied by spontaneous quantum Hall effects[7-9]. Though recent experiments[20-23] have provided convincing evidence of strong electronic correlations near the CNP in BLG, the presence of gaps is difficult to establish because of the lack of direct spectroscopic measurements. Here we present transport measurements in ultra-clean double-gated BLG, using source-drain bias as a spectroscopic tool to resolve a gap of ~2 meV at the CNP. The gap can be closed by an electric field E\bot \sim13 mV/nm but increases monotonically with a magnetic field B, with an apparent particle-hole asymmetry above the gap, thus providing the first mapping of the ground states in BLG.Comment: 4 figure

Experiment on micron-sized particle production of iron ore by rapid unloading of liquid CO2

The average iron content of iron ore is &lt;30%; therefore, crushing, grinding, milling and other processing techniques must be executed before smelting. Currently, it is expensive to break iron ores using mechanical grinding. Experiments have been carried out to develop a novel approach of producing iron ore powder. First, the iron ore is placed in a high-pressure chamber, and then liquid CO2 is injected into the chamber. Second, considering energy recycling, after the iron ore pores are filled with liquid CO2, dissociative liquid CO2 is substituted and collected for cyclic utilization. Third, an initial high pressure is applied inside the chamber using a water pump in order to increase the energy input. Fourth, the pressure is rapidly unloaded. After penetration and gasification expansion, the iron ore will immediately be converted into micron-sized particles. Laser grain size analysis indicated that the grain size of the iron ore particles ranges between 30 and 50 pm, which will satisfy the requirements of gravity separation, magnetic separation and the flotation process. This is a highly efficient and low-cost method that has excellent industrial promotion value. (C) 2017 Elsevier B.V. All rights reserved.</p

Gig1, a novel antiviral effector involved in fish interferon response

Vertebrate interferon (IFN) response defenses against viral infection through the induction of hundreds of IFN-stimulated genes (ISGs). Most ISGs are conserved across vertebrates; however, little is known about the species-specific ISGs. In this study, we reported that grass carp reovirus (GCRV)-induced gene 1 (Gig1), previously screened as a virus-induced gene from UV-inactivated GCRV-infected crucian carp (Carassius auratus) blastulae embryonic (CAB) cells, was a typical fish ISG, which was significantly induced by intracellular poly(I:C) through retinoic acid-inducible gene I (RIG-I)-like receptors-triggered IFN signaling pathway. Transient or stable overexpression of Gig1 prevented GCRV replication efficiently in cultured fish cells. Strikingly, Gig1 homologs were found exclusively in fish species forming a novel gene family. These results illustrate that there exists a Gig1 gene family unique to fish species and the founding gene mediates a novel fish IFN antiviral pathway. (C) 2013 Elsevier Inc. All rights reserved.Vertebrate interferon (IFN) response defenses against viral infection through the induction of hundreds of IFN-stimulated genes (ISGs). Most ISGs are conserved across vertebrates; however, little is known about the species-specific ISGs. In this study, we reported that grass carp reovirus (GCRV)-induced gene 1 (Gig1), previously screened as a virus-induced gene from UV-inactivated GCRV-infected crucian carp (Carassius auratus) blastulae embryonic (CAB) cells, was a typical fish ISG, which was significantly induced by intracellular poly(I:C) through retinoic acid-inducible gene I (RIG-I)-like receptors-triggered IFN signaling pathway. Transient or stable overexpression of Gig1 prevented GCRV replication efficiently in cultured fish cells. Strikingly, Gig1 homologs were found exclusively in fish species forming a novel gene family. These results illustrate that there exists a Gig1 gene family unique to fish species and the founding gene mediates a novel fish IFN antiviral pathway. (C) 2013 Elsevier Inc. All rights reserved