Broad Autism Phenotype

Broad autism phenotype is characterized by impairments in cognitive, social, communicative, behavioral and personality domains of close relatives to autistic individuals. Initial data derived from studies conducted on autism reflect mild autistic symptoms observed in siblings and parents of autistic individuals and this might be considered as an endophenotype for autism. With this review, we have aimed to summarize and interpret the entity of broad autism phenotype, within the context of its diagnostic assessment, its symptoms and relevant studies conducted so far

A Comparison of DSM-IV-TR and DSM-5 Diagnostic Classifications in the Clinical Diagnosis of Autistic Spectrum Disorder

Aim of this study was to compare children diagnosed with Pervasive Developmental Disorder (PDD) according to DSM-IV-TR and DSM-5 diagnostic systems. One hundred fifty children aged between 3 and 15 years diagnosed with PDD by DSM-IV-TR were included. PDD symptoms were reviewed through psychiatric assessment based on DSM-IV-TR and DSM-5 criteria. Clinical severity was determined using Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC). A statistically significant decrease (19.3 %) was detected in the diagnostic ratio with DSM-5. Age and symptom severity differed significantly between those who were and were not diagnosed with PDD using DSM-5. B4 criteria in DSM-5 was most common criterion. Results indicate that individuals diagnosed with PDD by DSM-IV-TR criteria may not be diagnosed using DSM-5 criteria