65 research outputs found

    Is the PANSS used correctly? a systematic review

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    <p>Abstract</p> <p>Background</p> <p>The PANSS (Positive and Negative Syndrome Scale) is one of the most important rating instruments for patients with schizophrenia. Nevertheless, there is a long and ongoing debate in the psychiatric community regarding its mathematical properties.</p> <p>All 30 items range from 1 to 7 leading to a minimum total score of 30, implying that the PANSS is an interval scale. For such interval scales straightforward calculation of relative changes is not appropriate. To calculate outcome criteria based on a percent change as, e.g., the widely accepted response criterion, the scale has to be transformed into a ratio scale beforehand. Recent publications have already pointed out the pitfall that ignoring the scale level (interval vs. ratio scale) leads to a set of mathematical problems, potentially resulting in erroneous results concerning the efficacy of the treatment.</p> <p>Methods</p> <p>A Pubmed search based on the PRISMA statement of the highest-ranked psychiatric journals (search terms "PANSS" and "response") was carried out. All articles containing percent changes were included and methods of percent change calculation were analysed.</p> <p>Results</p> <p>This systematic literature research shows that the majority of authors (62%) actually appear to use incorrect calculations. In most instances the method of calculation was not described in the manuscript.</p> <p>Conclusions</p> <p>These alarming results underline the need for standardized procedures for PANSS calculations.</p

    Pharmacogenetics in schizophrenia: a review of clozapine studies

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    Logos or mythos: (de)legitimation strategies in confrontational discourses of sociocultural ethos

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    Within the broader framework of critical discourse analysis this article incorporates Bourdieu's (1991) concept of 'field' and 'habitus' into Bernstein's (1990) concept of 'voice' to show how the shifting articulation of agents and habituses correlates with confrontational coding orientations in oped articles that appeared in two Turkish newspapers With diametrically opposed ideological orientations at a moment of legitimacy crisis. In order to specify how the boundaries between the voices, which we label as logos and mythos, are created, maintained and reproduced, this article studies the discursive formulation of the op-ed articles as instances of legitimation discourse at three levels: (i) pragmatic, various strategies of (de)legitimation of controversial actions; (ii) semantic, the way discourse processes the representation of events in the experiential world into ideological packages congruent with the audience demand; and (iii) sociocultural and political, the way each newspaper self-legitimates its orientation to the world and delegitimates alternative discourses. Taking rationality as a reference point in understanding the difference between the coding orientations, a detailed examination of discursive structures is also presented in order to test the newspapers' compliance with the critical standard of reasonableness

    An Experimental Study of the Drying Mechanism of Olive Cake

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