203 research outputs found
Ratios of Elastic Scattering of Pions from 3H and 3He
We have measured the elastic-scattering ratios of normalized yields for
charged pions from 3H and 3He in the backward hemisphere. At 180 MeV, we
completed the angular distribution begun with our earlier measurements, adding
six data points in the angular range of 119 deg to 169 deg in the pi-nucleus
center of mass. We also measured an excitation function with data points at
142, 180, 220, and 256 MeV incident pion energy at the largest achievable angle
for each energy between 160 deg and 170 deg in the pi-nucleus center of mass.
This excitation function corresponds to the energies of our forward-hemisphere
studies. The data, taken as a whole, show an apparent role reversal of the two
charge-symmetric ratios r1 and r2 in the backward hemisphere. Also, for data >
100 deg we observe a strong dependence on the four-momentum transfer squared
(-t) for all of the ratios regardless of pion energy or scattering angle, and
we find that the superratio R data match very well with calculations based on
the forward-hemisphere data that predicts the value of the difference between
the even-nucleon radii of 3H and 3He. Comparisons are also made with recent
calculations incorporating different wave functions and double scattering
models.Comment: RevTex 8pages, 12 figure file
Instability of a Bose-Einstein Condensate with Attractive Interaction
We study the stability of a Bose-Einstein condensate of harmonically trapped
atoms with negative scattering length, specifically lithium 7. Our method is to
solve the time-dependent nonlinear Schrodinger equation numerically. For an
isolated condensate, with no gain or loss, we find that the system is stable
(apart from quantum tunneling) if the particle number N is less than a critical
number N_c. For N > N_c, the system collapses to high-density clumps in a
region near the center of the trap. The time for the onset of collapse is on
the order of 1 trap period. Within numerical uncertainty, the results are
consistent with the formation of a "black hole" of infinite density
fluctuations, as predicted by Ueda and Huang. We obtain numerically N_c
approximately 1251. We then include gain-loss mechanisms, i.e., the gain of
atoms from a surrounding "thermal cloud", and the loss due to two- and
three-body collisions. The number N now oscillates in a steady state, with a
period of about 145 trap periods. We obtain N_c approximately 1260 as the
maximum value in the oscillations.Comment: Email correspondence to [email protected] ; 18 pages and 9 EPS
figures, using REVTeX and BoxedEPS macro
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Inhomogeneous ferromagnetism mimics signatures of the topological Hall effect in SrRuO3 films
Topological transport phenomena in magnetic materials are a major topic of current condensed matter research. One of the most widely studied phenomena is the topological Hall effect (THE), which is generated via spin-orbit interactions between conduction electrons and topological spin textures such as skyrmions. We report a comprehensive set of Hall effect and magnetization measurements on epitaxial films of the prototypical ferromagnetic metal SrRuO3 the magnetic and transport properties of which were systematically modulated by varying the concentration of Ru vacancies. We observe Hall effect anomalies that closely resemble signatures of the THE, but a quantitative analysis demonstrates that they result from inhomogeneities in the ferromagnetic magnetization caused by a nonrandom distribution of Ru vacancies. As such inhomogeneities are difficult to avoid and are rarely characterized independently, our results call into question the identification of topological spin textures in numerous prior transport studies of quantum materials, heterostructures, and devices. Firm conclusions regarding the presence of such textures must meet stringent conditions such as probes that couple directly to the noncollinear magnetization on the atomic scale
Dynamical properties of the unitary Fermi gas: collective modes and shock waves
We discuss the unitary Fermi gas made of dilute and ultracold atoms with an
infinite s-wave inter-atomic scattering length. First we introduce an efficient
Thomas-Fermi-von Weizsacker density functional which describes accurately
various static properties of the unitary Fermi gas trapped by an external
potential. Then, the sound velocity and the collective frequencies of
oscillations in a harmonic trap are derived from extended superfluid
hydrodynamic equations which are the Euler-Lagrange equations of a
Thomas-Fermi-von Weizsacker action functional. Finally, we show that this
amazing Fermi gas supports supersonic and subsonic shock waves.Comment: 9 pages, 3 figures, invited talk at the International Workshop
"Critical Stability 2011" (Erice, October 2011), to be published in the
journal Few Body System
Control, Elimination, and Eradication of River Blindness: Scenarios, Timelines, and Ivermectin Treatment Needs in Africa
River blindness (onchocerciasis) causes severe itching, skin lesions, and vision impairment including blindness. More than 99% of all current cases are found in sub-Saharan Africa. Fortunately, vector control and community-directed treatment with ivermectin have significantly reduced morbidity. Studies in Mali and Senegal proved the feasibility of elimination with ivermectin administration. The treatment goal is shifting from control to elimination in endemic African regions. Given limited resources, national and global policymakers need a rigorous analysis comparing investment options. For this, we developed scenarios for alternative treatment goals and compared treatment timelines and drug needs between the scenarios. Control, elimination, and eradication scenarios were developed with reference to current standard practices, large-scale studies, and historical data. For each scenario, the timeline when treatment is expected to stop at country level was predicted using a dynamical transmission model, and ivermectin treatment needs were predicted based on population in endemic areas, treatment coverage data, and the frequency of community-directed treatment. The control scenario requires community-directed treatment with ivermectin beyond 2045 with around 2.63 billion treatments over 2013–2045; the elimination scenario, until 2028 in areas where feasible, but beyond 2045 in countries with operational challenges, around 1.15 billion treatments; and the eradication scenario, lasting until 2040, around 1.30 billion treatments. The eradication scenario is the most favorable in terms of the timeline of the intervention phase and treatment needs. For its realization, strong health systems and political will are required to overcome epidemiological and political challenges
A real-world evaluation of radium-223 in combination with abiraterone or enzalutamide for the treatment of metastatic castration-resistant prostate cancer
Introduction Radium-223, abiraterone, and enzalutamide have each been shown to significantly improve survival as monotherapy in patients with metastatic castration-resistant prostate cancer. However, effects of combination radium-223 plus abiraterone or enzalutamide on survival and safety remain unclear. Patients and methods This single-center retrospective cohort study used electronic health record data of patients with metastatic castration-resistant prostate cancer and bone metastases who were treated with radium-223 between April 1, 2014 and February 19, 2019. Patients who received radium-223 monotherapy were compared to patients who received a combination of radium-223 plus either abiraterone or enzalutamide. The primary endpoint was overall survival. Secondary endpoints included progression-free survival, time to symptomatic skeletal event, symptomatic skeletal event-free survival, and incidence of drug-related adverse events. Time-to-event analyses were estimated by log rank tests using Kaplan-Meier curves. Hazard ratios and 95% confidence intervals were derived from Cox proportional hazards models. Chi-square tests evaluated difference in serious adverse events between the two arms. Results A total of 60 patients met inclusion criteria (n = 41 in the monotherapy arm, n = 19 in the combination arm). Differences in median overall survival were not observed (12.7 vs. 12.8 months; HR 1.15, 95% CI 0.59-2.23; P = 0.68), but median progression-free survival was significantly longer in the combination arm (7.6 vs. 4.9 months; HR 1.94, 95% CI 1.11-3.40; P = 0.02). Significant differences were not observed in time to first SSE (P = 0.97), SSE-free survival (P = 0.16), or in the overall incidence of serious adverse events (P = 0.45). Conclusion Combination radium-223 plus abiraterone or enzalutamide did not improve overall survival, but prolonged progression-free survival without increasing the incidence of serious adverse events in metastatic castration-resistant prostate cancer patients with bone metastases. However, these results are limited by small numbers and patient selection inherent in retrospective analysis
Phase II trial of palbociclib in patients with metastatic urothelial cancer after failure of first-line chemotherapy
Background: The majority of urothelial cancers (UC) harbor alterations in retinoblastoma (Rb) pathway genes that can lead to loss of Rb tumour suppressor function. Palbociclib is an oral, selective inhibitor of CDK 4/6 that restores Rb function and promotes cell cycle arrest. Methods: In this phase II trial, patients with metastatic platinum-refractory UC molecularly selected for p16 loss and intact Rb by tumour immunohistochemistry received palbociclib 125 mg p.o. daily for 21 days of a 28-day cycle. Primary endpoint was progression-free survival at 4 months (PFS4) using a Simon’s two-stage design. Next-generation sequencing including Rb pathway alterations was conducted. Results: Twelve patients were enrolled and two patients (17%) achieved PFS4 with insufficient activity to advance to stage 2. No responses were seen. Median PFS was 1.9 months (95% CI 1.8–3.7 months) and median overall survival was 6.3 months (95% CI 2.2–12.6 months). Fifty-eight percent of patients had grade ≥3 hematologic toxicity. There were no CDKN2A alterations found and no correlation of Rb pathway alterations with clinical outcome. Conclusions: Palbociclib did not demonstrate meaningful activity in selected patients with platinum-refractory metastatic UC. Further development of palbociclib should only be considered with improved integral biomarker selection or in rational combination with other therapies
Theory and Applications of Non-Relativistic and Relativistic Turbulent Reconnection
Realistic astrophysical environments are turbulent due to the extremely high
Reynolds numbers. Therefore, the theories of reconnection intended for
describing astrophysical reconnection should not ignore the effects of
turbulence on magnetic reconnection. Turbulence is known to change the nature
of many physical processes dramatically and in this review we claim that
magnetic reconnection is not an exception. We stress that not only
astrophysical turbulence is ubiquitous, but also magnetic reconnection itself
induces turbulence. Thus turbulence must be accounted for in any realistic
astrophysical reconnection setup. We argue that due to the similarities of MHD
turbulence in relativistic and non-relativistic cases the theory of magnetic
reconnection developed for the non-relativistic case can be extended to the
relativistic case and we provide numerical simulations that support this
conjecture. We also provide quantitative comparisons of the theoretical
predictions and results of numerical experiments, including the situations when
turbulent reconnection is self-driven, i.e. the turbulence in the system is
generated by the reconnection process itself. We show how turbulent
reconnection entails the violation of magnetic flux freezing, the conclusion
that has really far reaching consequences for many realistically turbulent
astrophysical environments. In addition, we consider observational testing of
turbulent reconnection as well as numerous implications of the theory. The
former includes the Sun and solar wind reconnection, while the latter include
the process of reconnection diffusion induced by turbulent reconnection, the
acceleration of energetic particles, bursts of turbulent reconnection related
to black hole sources as well as gamma ray bursts. Finally, we explain why
turbulent reconnection cannot be explained by turbulent resistivity or derived
through the mean field approach.Comment: 66 pages, 24 figures, a chapter of the book "Magnetic Reconnection -
Concepts and Applications", editors W. Gonzalez, E. N. Parke
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