5 research outputs found
Life in Data”—Outcome of a Multi-Disciplinary, Interactive Biobanking Conference Session on Sample Data
©Sara Y. Nussbeck et al. 2016; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. The article attached is the publisher's pdf
HDAC1 links early life stress to schizophrenia-like phenotypes.
Significance
Early life stress (ELS) is an important risk factor for schizophrenia. Our study shows that ELS in mice increases the levels of histone-deacetylase (HDAC) 1 in brain and blood. Although altered
Hdac1
expression in response to ELS is widespread, increased
Hdac1
levels in the prefrontal cortex are responsible for the development of schizophrenia-like phenotypes. In turn, administration of an HDAC inhibitor ameliorates ELS-induced schizophrenia-like phenotypes. We also show that
Hdac1
levels are increased in the brains of patients with schizophrenia and in blood from patients who suffered from ELS, suggesting that the analysis of
Hdac1
expression in blood could be used for patient stratification and individualized therapy.
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