211 research outputs found

    Jewish Revenge: Haredi Action in the Zionist Sphere

    Get PDF
    This is a pre-copyedited version of an article accepted for publication in (journal title, volume and issue numbers, and year) following peer review. The definitive publisher-authenticated version is available from Wayne State University Press.Jewish ultra-Orthodox (Haredi) cinema in Israel has become increasingly prominent in recent years. Emerging as a highly controversial, secluded, and gender-segregated form of “amateur cinema,” it is currently seeing gradual professionalization. This article discusses Haredi cinema in the context of the Haredi community’s relationship with the Israeli state and the doctrine of Zionism. Appropriating generic conventions of mainstream Hollywood cinema, yet keeping within the secluded Haredi space, this form of minority cinema functions as an alternative (virtual) sphere in which a complex set of negotiations occurs between Jewish ultra-Orthodox ideals and those of the surrounding Israeli society and Zionism. It is reflective of and engaged in the production of recent social and discursive transformations within the Haredi community in Israel. We examine this phenomenon through a focused analysis of the male action genre, specifically the popular series Jewish Revenge (Yehuda Grovais, 2000–2010). As we demonstrate, the mode of representation and the narratives of these films bring models of masculinities and notions of heroism under scrutiny. The Zionist narrative, the national body, and the (imaginary) place of the Haredi within it are being reconfigured through the prism of body politics and fantasies of transgression

    Traditional Gender Roles and Effects of Dementia Caregiving within a South Asian Ethnic Group in England

    Get PDF
    Background: Despite the integral role that women play in the care of older adults in South Asian families, limited empirical data are available on the impact of migration from South Asia to England. The purpose of this research was to examine caring for a family member with dementia from a gender role perspective. Methods: Data were gathered in two phases: (1) focus groups and (2) semi-structured interviews. Focus groups were held with the general public, and semi-structured interviews were conducted with family carers. Data were audio-recorded and analysed using thematic analysis. The NVivo qualitative software was utilised to simplify the thematic analysis. Results: While traditionally family care for frail older adults has been mainly provided by women in South Asian families, the samples in this study revealed how women’s attitudes towards caregiving are changing in British societies. Conclusion: There is a dearth of research about socioeconomic transformations in South Asian women’s migration to Western countries that could contribute to deterring them from providing family care. More research is warranted to understand the ways in which migration shapes gender relations in South Asian families and its impact on care for the frail elderly

    Schizophrenia is not associated with the ERBB3 gene in a Han Chinese population sample: Results from case-control and family-based studies

    Get PDF
    ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3), encoding a receptor of neuregulin-1 (NRG1), has been considered a functional candidate gene for schizophrenia susceptibility. In order to investigate a relationship between ERBB3 gene and schizophrenia in the Chinese population, case-control and family-based studies were carried out in 470 cases matched by controls, and in 532 family trios. Our results failed to show any evidence of significant association between the ERBB3 rs2292238 polymorphism and schizophrenia

    Genome-Wide Divergence of DNA Methylation Marks in Cerebral and Cerebellar Cortices

    Get PDF
    Emerging evidence suggests that DNA methylation plays an expansive role in the central nervous system (CNS). Large-scale whole genome DNA methylation profiling of the normal human brain offers tremendous potential in understanding the role of DNA methylation in brain development and function.Using methylation-sensitive SNP chip analysis (MSNP), we performed whole genome DNA methylation profiling of the prefrontal, occipital, and temporal regions of cerebral cortex, as well as cerebellum. These data provide an unbiased representation of CpG sites comprising 377,509 CpG dinucleotides within both the genic and intergenic euchromatic region of the genome. Our large-scale genome DNA methylation profiling reveals that the prefrontal, occipital, and temporal regions of the cerebral cortex compared to cerebellum have markedly different DNA methylation signatures, with the cerebral cortex being hypermethylated and cerebellum being hypomethylated. Such differences were observed in distinct genomic regions, including genes involved in CNS function. The MSNP data were validated for a subset of these genes, by performing bisulfite cloning and sequencing and confirming that prefrontal, occipital, and temporal cortices are significantly more methylated as compared to the cerebellum.These findings are consistent with known developmental differences in nucleosome repeat lengths in cerebral and cerebellar cortices, with cerebrum exhibiting shorter repeat lengths than cerebellum. Our observed differences in DNA methylation profiles in these regions underscores the potential role of DNA methylation in chromatin structure and organization in CNS, reflecting functional specialization within cortical regions

    The DISC1 Pathway Modulates Expression of Neurodevelopmental, Synaptogenic and Sensory Perception Genes

    Get PDF
    Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder. There is evidence for genetic interplay between variants in DISC1 and in biologically interacting loci in psychiatric illness. DISC1 also associates with normal variance in behavioral and brain imaging phenotypes.Here, we analyze public domain datasets and demonstrate correlations between variants in the DISC1 pathway genes and levels of gene expression. Genetic variants of DISC1, NDE1, PDE4B and PDE4D regulate the expression of cytoskeletal, synaptogenic, neurodevelopmental and sensory perception proteins. Interestingly, these regulated genes include existing targets for drug development in depression and psychosis.Our systematic analysis provides further evidence for the relevance of the DISC1 pathway to major mental illness, identifies additional potential targets for therapeutic intervention and establishes a general strategy to mine public datasets for insights into disease pathways
    corecore