ROLE OF OFFSHORE JURISDICTIONS IN THE FOREIGN ECONOMIC ACTIVITY OF THE RUSSIAN COMPANIES

The impact offshore to the Russian economy began to develop because of the adverse investment climate in the country. This article is devoted to the analysis of problems of use of offshore jurisdictions in the foreign economic relations of Russia. Benefits and problems of use by entrepreneurs of offshore schemes are revealed

ROLE OF THE INTERNATIONAL ECONOMIC ORGANIZATIONS IN THE DECISION OF PROBLEM OF DEOFSHORIZATION IN THE FOREIGN COUNTRIES

In recent years problems of deofshorization were staticized in view of need of ensuring steady participation of the countries for international capital movement. In the article approaches of the international organizations to regulation of anti-ofshore activities at the present stage are generalized

ROLE OF OFFSHORE JURISDICTIONS IN THE FOREIGN ECONOMIC ACTIVITY OF THE RUSSIAN COMPANIES

The impact offshore to the Russian economy began to develop because of the adverse investment climate in the country. This article is devoted to the analysis of problems of use of offshore jurisdictions in the foreign economic relations of Russia. Benefits and problems of use by entrepreneurs of offshore schemes are revealed

ROLE OF THE INTERNATIONAL ECONOMIC ORGANIZATIONS IN THE DECISION OF PROBLEM OF DEOFSHORIZATION IN THE FOREIGN COUNTRIES

In recent years problems of deofshorization were staticized in view of need of ensuring steady participation of the countries for international capital movement. In the article approaches of the international organizations to regulation of anti-ofshore activities at the present stage are generalized

EVOLUTION OF THE CONCEPT AND INSTRUMENTS OF DEOFFSHORIZATION OF THE RUSSIAN ECONOMY

Offshore zones were widely used in the Russian economic practice that has led to contradictions between interests of business and the state. In the article tools and the directions of deoffshorization of the Russian economy at the present stage are considered and generalized

EVOLUTION OF THE CONCEPT AND INSTRUMENTS OF DEOFFSHORIZATION OF THE RUSSIAN ECONOMY

Offshore zones were widely used in the Russian economic practice that has led to contradictions between interests of business and the state. In the article tools and the directions of deoffshorization of the Russian economy at the present stage are considered and generalized

A clinical case of surgical treatment of complicated cataracts in a patient with high degree hyperopia

The aim of the study - to evaluate the clinical and functional visual results in a patient with complicated cataract on the background of high–gradehypermetropia after performing cataract phacoemulsification with intraocularlens implantation.Цель исследования- оценить клинико-функциональные зрительные результаты у пациента с осложненной катарактой на фоне гиперметропии высокой степени после выполнения факоэмульсификации катаракты с имплантацией интраокулярной линзы

Electronic educational resources as a means of improving the quality of teaching disciplines implemented at the department of microbiology, virology and immunology of FSBEI of the “Ural state medical university” Ministry of health of Russia

The purpose of the study is to analyze the possibilities of modern electronic educational resources to improve the quality of education.Цель исследования – анализ возможностей современных электронных образовательных ресурсов для повышения качества образования

Reservoir Topology in Deep Echo State Networks

Deep Echo State Networks (DeepESNs) recently extended the applicability of Reservoir Computing (RC) methods towards the field of deep learning. In this paper we study the impact of constrained reservoir topologies in the architectural design of deep reservoirs, through numerical experiments on several RC benchmarks. The major outcome of our investigation is to show the remarkable effect, in terms of predictive performance gain, achieved by the synergy between a deep reservoir construction and a structured organization of the recurrent units in each layer. Our results also indicate that a particularly advantageous architectural setting is obtained in correspondence of DeepESNs where reservoir units are structured according to a permutation recurrent matrix.Comment: Preprint of the paper published in the proceedings of ICANN 201

PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse

Introduction: Circulating monocytes are main source for tumor-associated macrophages (TAMs) that control tumor growth, angiogenesis, metastasis and therapy resistance. We raised the questions how monocyte programming is affected by growing tumors localized in colon and rectal sections, and how treatment onsets affect monocyte programming in the circulation. Methods: Patients with rectal cancer and colon cancer were enrolled in the study. Peripheral blood monocytes were characterized by phenotypic analysis using flow cytometry, by transcriptomic analysis using RNA sequencing and by gene expression analysis using real-time RT-PCR. Phenotypic analysis was performed with IF/confocal microscopy. Spatial transcriptomic analysis was applied using GeoMX DSP-NGS. Results: In patients with rectal cancer, increased amount of CCR2+ monocytes was indicative for the absence of both lymphatic and hematogenous metastasis. In contrast, in patients with colon cancer CD163+ monocytes were indicative for LN metastasis. NGS analysis identified tumor-specific transcriptional programming of monocytes in all CRC patients compared to healthy individuals. The key transcriptional difference between monocytes of patients with colon and rectal cancer was increased expression of PFKFB3, activator of glycolysis that is currently considered as therapy target for major solid cancers. PFKFB3-expressing monocyte-derived macrophages massively infiltrated tumor in colon. Nanostring technology identified correlation of PFKFB3 with amount and tumor-promoting properties of TAMs in colon but not in rectal cancer. PFKFB3 was indicative for tumor relapse specifically in colon cancer. Discussion: Our findings provide essential argument towards CRC definition to cover two clinically distinct cancers – colon cancer and rectal cancer, that differentially interact with innate immunity