Bibliometric cartography of information retrieval research by using co-word analysis

The aim of this study is to map the intellectual structure of the field of Information Retrieval (IR) during the period of 1987-1997. Co-word analysis was employed to reveal patterns and trends in the IR field by measuring the association strengths of terms representative of relevant publications or other texts produced in IR field. Data were collected from Science Citation Index (SCI) and Social Science Citation Index (SSCI) for the period of 1987-1997. In addition to the keywords added by the SCI and SSCI databases, other important keywords were extracted from titles and abstracts manually. These keywords were further standardized using vocabulary control tools. In order to trace the dynamic changes of the IR field, the whole 11-year period was further separated into two consecutive periods: 1987-1991 and 1992-1997. The results show that the IR field has some established research themes and it also changes rapidly to embrace new themes

Computational structure‐based drug design: Predicting target flexibility

The role of molecular modeling in drug design has experienced a significant revamp in the last decade. The increase in computational resources and molecular models, along with software developments, is finally introducing a competitive advantage in early phases of drug discovery. Medium and small companies with strong focus on computational chemistry are being created, some of them having introduced important leads in drug design pipelines. An important source for this success is the extraordinary development of faster and more efficient techniques for describing flexibility in three‐dimensional structural molecular modeling. At different levels, from docking techniques to atomistic molecular dynamics, conformational sampling between receptor and drug results in improved predictions, such as screening enrichment, discovery of transient cavities, etc. In this review article we perform an extensive analysis of these modeling techniques, dividing them into high and low throughput, and emphasizing in their application to drug design studies. We finalize the review with a section describing our Monte Carlo method, PELE, recently highlighted as an outstanding advance in an international blind competition and industrial benchmarks.We acknowledge the BSC-CRG-IRB Joint Research Program in Computational Biology. This work was supported by a grant from the Spanish Government CTQ2016-79138-R.J.I. acknowledges support from SVP-2014-068797, awarded by the Spanish Government.Peer ReviewedPostprint (author's final draft

Superconducting gap symmetry of Ba0.6K0.4Fe2As2 studied by angle-resolved photoemission spectroscopy

We have performed high-resolution angle-resolved photoemission spectroscopy on the optimally-doped Ba$_{0.6}$K$_{0.4}$Fe$_2$As$_2$ compound and determined the accurate momentum dependence of the superconducting (SC) gap in four Fermi-surface sheets including a newly discovered outer electron pocket at the M point. The SC gap on this pocket is nearly isotropic and its magnitude is comparable ($\Delta$ $\sim$ 11 meV) to that of the inner electron and hole pockets ($\sim$12 meV), although it is substantially larger than that of the outer hole pocket ($\sim$6 meV). The Fermi-surface dependence of the SC gap value is basically consistent with $\Delta$($k$) = $\Delta$$_0$cos$k_x$cos$k_y$ formula expected for the extended s-wave symmetry. The observed finite deviation from the simple formula suggests the importance of multi-orbital effects.Comment: 4 pages, 3 figures, 1 tabl

H-Alpha and Hard X-Ray Observations of a Two-Ribbon Flare Associated with a Filament Eruption

We perform a multi-wavelength study of a two-ribbon flare on 2002 September 29 and its associated filament eruption, observed simultaneously in the H-alpha line by a ground-based imaging spectrograph and in hard X-rays by RHESSI. The flare ribbons contain several H-alpha bright kernels that show different evolutional behaviors. In particular, we find two kernels that may be the footpoints of a loop. A single hard X-ray source appears to cover these two kernels and to move across the magnetic neutral line. We explain this as a result of the merging of two footpoint sources that show gradually asymmetric emission owing to an asymmetric magnetic topology of the newly reconnected loops. In one of the H-alpha kernels, we detect a continuum enhancement at the visible wavelength. By checking its spatial and temporal relationship with the hard X-ray emission, we ascribe it as being caused by electron beam precipitation. In addition, we derive the line-of-sight velocity of the filament plasma based on the Doppler shift of the filament-caused absorption in the H-alpha blue wing. The filament shows rapid acceleration during the impulsive phase. These observational features are in principal consistent with the general scenario of the canonical two-ribbon flare model.Comment: 15 pages, 5 figures, accepted for publication in Ap

High-Q bismuth silicate nonlinear glass microsphere resonators

The fabrication and characterization of a bismuth-silicate glass microsphere resonator has been demonstrated. At wavelengths near 1550 nm, high-modes can be efficiently excited in a 179 µm diameter bismuth-silicate glass microsphere via evanescent coupling using a tapered silica fiber with a waist diameter of circa 2 µm. Resonances with Q-factors as high as were observed. The dependence of the spectral response on variations in the input power level was studied in detail to gain an insight into power-dependent thermal resonance shifts. Because of their high nonlinearity and high- factors, bismuth-silicate glass microspheres offer the potential for robustly assembled fully integrated all-optical switching devices