12,728 research outputs found
Coherent population trapping and dynamical instability in the nonlinearly coupled atom-molecule system
We study the possibility of creating a coherent population trapping (CPT)
state, involving free atomic and ground molecular condensates, during the
process of associating atomic condensate into molecular condensate. We
generalize the Bogoliubov approach to this multi-component system and study the
collective excitations of the CPT state in the homogeneous limit. We develop a
set of analytical criteria based on the relationship among collisions involving
atoms and ground molecules, which are found to strongly affect the stability
properties of the CPT state, and use it to find the stability diagram and to
systematically classify various instabilities in the long-wavelength limit.Comment: 11 pages, 8 figure
Cosmological Inhomogeneities with Bose-Einstein Condensate Dark Matter
We consider the growth of cosmological perturbations to the energy density of
dark matter during matter domination when dark matter is a scalar field that
has undergone Bose-Einstein condensation. We study these inhomogeneities within
the framework of both Newtonian gravity, where the calculation and results are
more transparent, and General Relativity. The direction we take is to derive
analytical expressions, which can be obtained in the small pressure limit.
Throughout we compare our results to those of the standard cosmology, where
dark matter is assumed pressureless, using our analytical expressions to
showcase precise differences. We find, compared to the standard cosmology, that
Bose-Einstein condensate dark matter leads to a scale factor, gravitational
potential and density contrast that increase at faster rates.Comment: 17 pages, 2 figures; typos corrected, references adde
Continuous variable entanglement sharing in non-inertial frames
We study the distribution of entanglement between modes of a free scalar
field from the perspective of observers in uniform acceleration. We consider a
two-mode squeezed state of the field from an inertial perspective, and
analytically study the degradation of entanglement due to the Unruh effect, in
the cases of either one or both observers undergoing uniform acceleration. We
find that for two observers undergoing finite acceleration, the entanglement
vanishes between the lowest frequency modes. The loss of entanglement is
precisely explained as a redistribution of the inertial entanglement into
multipartite quantum correlations among accessible and unaccessible modes from
a non-inertial perspective. We show that classical correlations are also lost
from the perspective of two accelerated observers but conserved if one of the
observers remains inertial.Comment: 19 pages, 13 EPS figures (most low-res due to oversize); terminology
revise
A preexisting rare PIK3CA e545k subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling
Combined MEK and CDK4/6 inhibition (MEKi + CDK4i) has shown promising clinical outcomes in patients with NRAS- mutant melanoma. Here, we interrogated longitudinal biopsies from a patient who initially responded to MEKi + CDK4i therapy but subsequently developed resistance. Whole-exome sequencing and functional validation identified an acquired PIK3CA E545K mutation as conferring drug resistance. We demonstrate that PIK3CA E545K preexisted in a rare subpopulation that was missed by both clinical and research testing, but was revealed upon multiregion sampling due to PIK3CA E545K being nonuniformly distributed. This resistant population rapidly expanded after the initiation of MEKi + CDK4i therapy and persisted in all successive samples even after immune checkpoint therapy and distant metastasis. Functional studies identified activated S6K1 as both a key marker and specific therapeutic vulnerability downstream of PIK3CA E545K -induced resistance. These results demonstrate that difficult-to-detect preexisting resistance mutations may exist more often than previously appreciated and also posit S6K1 as a common downstream therapeutic nexus for the MAPK, CDK4/6, and PI3K pathways. SIGNIFICANCE: We report the first characterization of clinical acquired resistance to MEKi + CDK4i, identifying a rare preexisting PIK3CA E545K subpopulation that expands upon therapy and exhibits drug resistance. We suggest that single-region pretreatment biopsy is insufficient to detect rare, spatially segregated drug-resistant subclones. Inhibition of S6K1 is able to resensitize PIK3CA E545K -expressing NRAS-mutant melanoma cells to MEKi + CDK4i. © 2018 AAC
Inflationary universe in loop quantum cosmology
Loop quantum cosmology provides a nice solution of avoiding the big bang
singularity through a big bounce mechanism in the high energy region. In loop
quantum cosmology an inflationary universe is emergent after the big bounce, no
matter what matter component is filled in the universe. A super-inflation phase
without phantom matter will appear in a certain way in the initial stage after
the bounce; then the universe will undergo a normal inflation stage. We discuss
the condition of inflation in detail in this framework. Also, for slow-roll
inflation, we expect the imprint from the effects of the loop quantum cosmology
should be left in the primordial perturbation power spectrum. However, we show
that this imprint is too weak to be observed.Comment: 21 pages, 4 figures; accepted for publication in JCA
The Large-scale and Small-scale Clustering of Lyman-Break Galaxies at 3.5 < z< 5.5 from the GOODS survey
We report on the angular correlation function of Lyman-break galaxies (LBGs)
at z~4 and 5 from deep samples obtained from the Great Observatories Deep
Origins Survey (GOODS). Similar to LBGs at z~3, the shape of w(theta) of the
GOODS LBGs is well approximated by a power-law with slope beta~0.6 at angular
separation theta > 10 arcsec. The clustering strength of z~4, 5 LBGs also
depends on the rest-frame UV luminosity, with brighter galaxies more strongly
clustered than fainter ones, implying a general correlation between halos' mass
and LBGs' star-formation rate. At smaller separations, w(theta) of deep samples
significantly exceeds the extrapolation of the large-scale power-law fit,
implying enhanced spatial clustering at scales r < 1 Mpc. We also find that
bright LBGs statistically have more faint companions on scales theta < 20
arcsec than fainter ones, showing that the enhanced small-scale clustering is
very likely due to sub-structure, namely the fact that massive halos can host
multiple galaxies. A simple model for the halo occupation distribution and the
CDM halo mass function reproduce well the observed w(theta). The scaling
relationship of the clustering strength with volume density and with redshift
is quantitatively consistent with that of CDM halos. A comparison of the
clustering strength of three samples of equal luminosity limit at z ~ 3, 4 and
5 shows that the LBGs at z~5 are hosted in halos about one order of magnitude
less massive than those in the lower redshift bins, suggesting that
star-formation was more efficient at higher-redshift.Comment: replaced with the version accepted for publication in ApJ. 46 pages,
10 figures; minor changes to text, one subsection adde
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