3,100 research outputs found
Upper critical fields and thermally-activated transport of Nd(O_0.7F_0.3)FeAs single crystal
We present measurements of the resistivity and the upper critical field H_c2
of Nd(O_0.7F_0.3)FeAs single crystals in strong DC and pulsed magnetic fields
up to 45 T and 60 T, respectively. We found that the field scale of H_c2 is
comparable to ~100 T of high T_c cuprates. H_c2(T) parallel to the c-axis
exhibits a pronounced upward curvature similar to what was extracted from
earlier measurements on polycrystalline samples. Thus this behavior is indeed
an intrinsic feature of oxypnictides, rather than manifestation of vortex
lattice melting or granularity. The orientational dependence of H_c2 shows
deviations from the one-band Ginzburg-Landau scaling. The mass anisotropy
decreases as T decreases, from 9.2 at 44K to 5 at 34K. Spin dependent
magnetoresistance and nonlinearities in the Hall coefficient suggest
contribution to the conductivity from electron-electron interactions modified
by disorder reminiscent that of diluted magnetic semiconductors. The Ohmic
resistivity measured below T_c but above the irreversibility field exhibits a
clear Arrhenius thermally activated behavior over 4-5 decades. The activation
energy has very different field dependencies for H||ab and H\perp ab. We
discuss to what extent different pairing scenarios can manifest themselves in
the observed behavior of H_{c2}, using the two-band model of superconductivity.
The results indicate the importance of paramagnetic effects on H_c2(T),which
may significantly reduce H_c2(0) as compared toH_c2(0)~200-300 T based on
extrapolations of H_c2(T) near T_c down to low temperatures.Comment: 11 pages, 16 figure
A balanced homodyne detector for high-rate Gaussian-modulated coherent-state quantum key distribution
We discuss excess noise contributions of a practical balanced homodyne
detector in Gaussian-modulated coherent-state (GMCS) quantum key distribution
(QKD). We point out the key generated from the original realistic model of GMCS
QKD may not be secure. In our refined realistic model, we take into account
excess noise due to the finite bandwidth of the homodyne detector and the
fluctuation of the local oscillator. A high speed balanced homodyne detector
suitable for GMCS QKD in the telecommunication wavelength region is built and
experimentally tested. The 3dB bandwidth of the balanced homodyne detector is
found to be 104MHz and its electronic noise level is 13dB below the shot noise
at a local oscillator level of 8.5*10^8 photon per pulse. The secure key rate
of a GMCS QKD experiment with this homodyne detector is expected to reach
Mbits/s over a few kilometers.Comment: 22 pages, 11 figure
Appearance of Half-Metallicity in the Quaternary Heusler Alloys
I report systematic first-principle calculations of the quaternary Heusler
alloys like Co[CrMn]Al, CoMn[AlSn] and
[FeCo]MnAl. I show that when the two limiting cases (x=0 or 1)
correspond to a half-metallic compound, so do the intermediate cases. Moreover
the total spin moment in scales linearly with the total number of
valence electrons (and thus with the concentration ) following the
relation , independently of the origin of the extra valence
electrons, confirming the Slater-Pauling behavior of the normal Heusler alloys.
Finally I discuss in all cases the trends in the atomic projected DOSs and in
the atomic spin moments.Comment: 4 pages, 3 figures, 2 Table
Transcript-indexed ATAC-seq for precision immune profiling.
T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding genes with assay for transposase-accessible chromatin with sequencing (ATAC-seq) analysis at the single-cell level to provide information on the TCR specificity and epigenomic state of individual T cells. By using this approach, termed transcript-indexed ATAC-seq (T-ATAC-seq), we identified epigenomic signatures in immortalized leukemic T cells, primary human T cells from healthy volunteers and primary leukemic T cells from patient samples. In peripheral blood CD4+ T cells from healthy individuals, we identified cis and trans regulators of naive and memory T cell states and found substantial heterogeneity in surface-marker-defined T cell populations. In patients with a leukemic form of cutaneous T cell lymphoma, T-ATAC-seq enabled identification of leukemic and nonleukemic regulatory pathways in T cells from the same individual by allowing separation of the signals that arose from the malignant clone from the background T cell noise. Thus, T-ATAC-seq is a new tool that enables analysis of epigenomic landscapes in clonal T cells and should be valuable for studies of T cell malignancy, immunity and immunotherapy
Fluctuation-driven capacity distribution in complex networks
Maximizing robustness and minimizing cost are common objectives in the design
of infrastructure networks. However, most infrastructure networks evolve and
operate in a highly decentralized fashion, which may significantly impact the
allocation of resources across the system. Here, we investigate this question
by focusing on the relation between capacity and load in different types of
real-world communication and transportation networks. We find strong empirical
evidence that the actual capacity of the network elements tends to be similar
to the maximum available capacity, if the cost is not strongly constraining. As
more weight is given to the cost, however, the capacity approaches the load
nonlinearly. In particular, all systems analyzed show larger unoccupied
portions of the capacities on network elements subjected to smaller loads,
which is in sharp contrast with the assumptions involved in (linear) models
proposed in previous theoretical studies. We describe the observed behavior of
the capacity-load relation as a function of the relative importance of the cost
by using a model that optimizes capacities to cope with network traffic
fluctuations. These results suggest that infrastructure systems have evolved
under pressure to minimize local failures, but not necessarily global failures
that can be caused by the spread of local damage through cascading processes
Improving clinical utility of GAD65 autoantibodies by electrochemiluminescence assay and clinical phenotype when identifying autoimmune adult-onset diabetes
AzTEC 1.1 mm Observations of the MBM12 Molecular Cloud
We present 1.1 mm observations of the dust continuum emission from the MBM12
high-latitude molecular cloud observed with the Astronomical Thermal Emission
Camera (AzTEC) mounted on the James Clerk Maxwell Telescope on Mauna Kea,
Hawaii. We surveyed a 6.34 deg centered on MBM12, making this the largest
area that has ever been surveyed in this region with submillimeter and
millimeter telescopes. Eight secure individual sources were detected with a
signal-to-noise ratio of over 4.4. These eight AzTEC sources can be considered
to be real astronomical objects compared to the other candidates based on
calculations of the false detection rate. The distribution of the detected 1.1
mm sources or compact 1.1 mm peaks is spatially anti-correlated with that of
the 100 micronm emission and the CO emission. We detected the 1.1 mm
dust continuum emitting sources associated with two classical T Tauri stars,
LkHalpha262 and LkHalpha264. Observations of spectral energy distributions
(SEDs) indicate that LkHalpha262 is likely to be Class II (pre-main-sequence
star), but there are also indications that it could be a late Class I
(protostar). A flared disk and a bipolar cavity in the models of Class I
sources lead to more complicated SEDs. From the present AzTEC observations of
the MBM12 region, it appears that other sources detected with AzTEC are likely
to be extragalactic and located behind MBM12. Some of these have radio
counterparts and their star formation rates are derived from a fit of the SEDs
to the photometric evolution of galaxies in which the effects of a dusty
interstellar medium have been included.Comment: 8 pages, 6 figures, The Astrophysical Journal, in pres
Feasibility of quantum key distribution through dense wavelength division multiplexing network
In this paper, we study the feasibility of conducting quantum key
distribution (QKD) together with classical communication through the same
optical fiber by employing dense-wavelength-division-multiplexing (DWDM)
technology at telecom wavelength. The impact of the classical channels to the
quantum channel has been investigated for both QKD based on single photon
detection and QKD based on homodyne detection. Our studies show that the latter
can tolerate a much higher level of contamination from the classical channels
than the former. This is because the local oscillator used in the homodyne
detector acts as a "mode selector" which can suppress noise photons
effectively. We have performed simulations based on both the decoy BB84 QKD
protocol and the Gaussian modulated coherent state (GMCS) QKD protocol. While
the former cannot tolerate even one classical channel (with a power of 0dBm),
the latter can be multiplexed with 38 classical channels (0dBm power each
channel) and still has a secure distance around 10km. Preliminary experiment
has been conducted based on a 100MHz bandwidth homodyne detector.Comment: 18 pages, 5 figure
The Layer 0 Inner Silicon Detector of the D0 Experiment
This paper describes the design, fabrication, installation and performance of
the new inner layer called Layer 0 (L0) that was inserted in the existing Run
IIa Silicon Micro-Strip Tracker (SMT) of the D0 experiment at the Fermilab
Tevatron collider. L0 provides tracking information from two layers of sensors,
which are mounted with center lines at a radial distance of 16.1 mm and 17.6 mm
respectively from the beam axis. The sensors and readout electronics are
mounted on a specially designed and fabricated carbon fiber structure that
includes cooling for sensor and readout electronics. The structure has a thin
polyimide circuit bonded to it so that the circuit couples electrically to the
carbon fiber allowing the support structure to be used both for detector
grounding and a low impedance connection between the remotely mounted hybrids
and the sensors.Comment: 28 pages, 9 figure
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Decreases in Antimicrobial Use Associated With Multihospital Implementation of Electronic Antimicrobial Stewardship Tools.
BackgroundAntimicrobial stewards may benefit from comparative data to inform interventions that promote optimal inpatient antimicrobial use.MethodsAntimicrobial stewards from 8 geographically dispersed Veterans Affairs (VA) inpatient facilities participated in the development of antimicrobial use visualization tools that allowed for comparison to facilities of similar complexity. The visualization tools consisted of an interactive web-based antimicrobial dashboard and, later, a standardized antimicrobial usage report updated at user-selected intervals. Stewards participated in monthly learning collaboratives. The percent change in average monthly antimicrobial use (all antimicrobial agents, anti-methicillin-resistant Staphylococcus aureus [anti-MRSA] agents, and antipseudomonal agents) was analyzed using a pre-post (January 2014-January 2016 vs July 2016-January 2018) design with segmented regression and external comparison with uninvolved control facilities (n = 118).ResultsIntervention sites demonstrated a 2.1% decrease (95% confidence interval [CI], -5.7% to 1.6%) in total antimicrobial use pre-post intervention vs a 2.5% increase (95% CI, 0.8% to 4.1%) in nonintervention sites (absolute difference, 4.6%; P = .025). Anti-MRSA antimicrobial use decreased 11.3% (95% CI, -16.0% to -6.3%) at intervention sites vs a 6.6% decrease (95% CI, -9.1% to -3.9%) at nonintervention sites (absolute difference, 4.7%; P = .092). Antipseudomonal antimicrobial use decreased 3.4% (95% CI, -8.2% to 1.7%) at intervention sites vs a 3.6% increase (95% CI, 0.8% to 6.5%) at nonintervention sites (absolute difference, 7.0%; P = .018).ConclusionsComparative data visualization tool use by stewards at 8 VA facilities was associated with significant reductions in overall antimicrobial and antipseudomonal use relative to uninvolved facilities
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