Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced qacute renal failure

The effect of acute renal failure (ARF) induced by ischemia/reperfusion (I/R) of rat kidney on the expression of organic anion transporters (OATs) was examined. The level of serum indoxyl sulfate (IS), a uremic toxin and substrate of OATs in renal tubules, shows a marked increase with the progression of ARF. However, this increase was significantly attenuated by ingestion of cobalt. The level of mRNA and protein of both rOAT1 and rOAT3 were markedly depressed in the ischemic kidney. The uptake of p-aminohippuric acid (PAH) and estrone sulfate (ES) by renal slices of ischemic rats was significantly reduced compared to control rats. Renal slices taken from ischemic rats treated with cobalt displayed significantly elevated levels of ES uptake. Cobalt intake did not affect PAH uptake, indicating the functional restoration of rOAT3 but not rOAT1. The expression of Na+/K+-ATPase was markedly depressed in the ischemic kidney, suggesting that the inward Na+ gradient in renal tubular cells had collapsed, thereby reducing the outward gradient of α-ketoglutarate, a driving force of both rOATs. The decreased expression of Na+/K+-ATPase was significantly restored by cobalt treatment. Our results suggest that the downregulation of renal rOAT1 and rOAT3 could be responsible for the increase in serum IS level of ischemic rats. Cobalt treatment has a significant protective effect on ischemia-induced ARF, being accompanied by the restoration of rOAT3 and/or Na+/K+-ATPase function

Fusion product diagnostics planned for Large Helical Device deuterium experiment

Deuterium experiment on the Large Helical Device (LHD) is now being planned at the National Institute for Fusion Science. The fusion product diagnostics systems currently considered for installation on LHD are described in this paper. The systems will include a time-resolved neutron yield monitor based on neutron gas counters, a time-integrated neutron yield monitor based on activation techniques, a multicollimator scintillation detector array for diagnosing spatial distribution of neutron emission rate, 2.5 MeV neutron spectrometer, 14 MeV neutron counter, and prompt γ-ray diagnostics

侵襲臓器, N因子別にみた T3N0-2M0 非小細胞肺癌の手術成績の検討

金沢大学医薬保健研究域医学系The purpose of this study was to evaluate the results of surgical treatment of T3N0-2M0 non-small cell lung cancer according to involved organ and nodal status. Between 1973 and July 1997, 157 patients with T3 non-small cell lung cancer were surgically treated in our department. Five-year survival was 23% for all cases, 35% for patients with curative resection, and 0% for patients with non-curative resection (p < 0.001). Five-year survival rate of patients with T3N0, T3N1, and T3N2 was 37%, 39%, and 3%, respectively (T3N0 vs T3N2, T3N1 vs T3N2, p < 0.01). According to the depth of chest wall involvement of T3N0 tumor, 5-year survival rate was 50% in the patients with the involvement of parietal pleura, 39% in the patients with the involvement of intercostal muscle, and 15% in the patients with the involvement of rib or more (parietal pleura vs rib or more, p < 0.05). In T3N0 patients with the involvement of only parietal pleura, the 5-year survival rate of parietal pleurectomy and en bloc chest wall resection was 43% and 46%, respectively (N.S.). Five-year survival rate of T3N1 patients with invasion in main stem bronchus was 46% and 3 of 5 patients of T3N0-1 tumor with pericardial invasion survived more than 5 years. From these results, T3N0 tumor involving chest wall without rib invasion, and T3N0-1 tumor involving main bronchus and pericardium are expected good survival. However, the prognosis of the patients with coexistent N2 disease or with incomplete resection remains poor in regardless with the type of involved organ. To correctly evaluate the surgical results of other types of T3 tumor, it is required to collect more cases or to perform multicenteric study

Upsilon (1S+2S+3S) production in d+Au and p+p collisions at sqrt(s_NN)=200 GeV and cold-nuclear matter effects

The three Upsilon states, Upsilon(1S+2S+3S), are measured in d+Au and p+p collisions at sqrt(s_NN)=200 GeV and rapidities 1.2<|y|<2.2 by the PHENIX experiment at the Relativistic Heavy-Ion Collider. Cross sections for the inclusive Upsilon(1S+2S+3S) production are obtained. The inclusive yields per binary collision for d+Au collisions relative to those in p+p collisions (R_dAu) are found to be 0.62 +/- 0.26 (stat) +/- 0.13 (syst) in the gold-going direction and 0.91 +/- 0.33 (stat) +/- 0.16 (syst) in the deuteron-going direction. The measured results are compared to a nuclear-shadowing model, EPS09 [JHEP 04, 065 (2009)], combined with a final-state breakup cross section, sigma_br, and compared to lower energy p+A results. We also compare the results to the PHENIX J/psi results [Phys. Rev. Lett. 107, 142301 (2011)]. The rapidity dependence of the observed Upsilon suppression is consistent with lower energy p+A measurements.Comment: 495 authors, 11 pages, 9 figures, 5 tables. Submitted to Phys. Rev. C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm