173 research outputs found
New effective nuclear forces with a finite-range three-body term and their application to AMD+GCM calculations
We propose new effective inter-nucleon forces with a finite-range three-body
operator. The proposed forces are suitable for describing the nuclear structure
properties over a wide mass number region, including the saturation point of
nuclear matter. The forces are applied to microscopic calculations of
() nuclei and O isotopes with a method of antisymmetrized molecular
dynamics. We present the characteristics of the forces and discuss the
importance of the finite-range three-body term.Comment: 15 pages, 11 figures, submitted to Phys.Rev.
Deformed Base Antisymmetrized Molecular Dynamics and its Application to ^{20}Ne
A new theoretical framework named as deformed base antisymmetrized molecular
dynamics that uses the localized triaxially deformed Gaussian as the single
particle wave packet is presented. The model space enables us to describe
sufficiently well the deformed mean-field structure as well as the cluster
structure and their mixed structure within the same framework. The improvement
over the original version of the antisymmetrized molecular dynamics which uses
the spherical Gaussian is verified by the application to
nucleus. The almost pure cluster structure of the
= band, the distortion of the cluster structure in the
= band and the dominance of the deformed mean-field structure of
the = band are confirmed and their observed properties are
reproduced. Especially, the intra-band E2 transition probabilities in
= and bands are reproduced without any effective charge.
Since it has been long known that the pure
cluster model underestimates the intra-band transitions in the
= band by about 30%, we consider that this success is due to the
sufficient description of the deformed mean-field structure in addition to the
cluster structure by the present framework. From the successful description of
, we expect that the present framework presents us with a
powerful approach for the study of the coexistence and interplay of the
mean-field structure and the cluster structure
An SU(N) Mott insulator of an atomic Fermi gas realized by large-spin Pomeranchuk cooling
The Hubbard model, containing only the minimum ingredients of nearest
neighbor hopping and on-site interaction for correlated electrons, has
succeeded in accounting for diverse phenomena observed in solid-state
materials. One of the interesting extensions is to enlarge its spin symmetry to
SU(N>2), which is closely related to systems with orbital degeneracy. Here we
report a successful formation of the SU(6) symmetric Mott insulator state with
an atomic Fermi gas of ytterbium (173Yb) in a three-dimensional optical
lattice. Besides the suppression of compressibility and the existence of charge
excitation gap which characterize a Mott insulating phase, we reveal an
important difference between the cases of SU(6) and SU(2) in the achievable
temperature as the consequence of different entropy carried by an isolated
spin. This is analogous to Pomeranchuk cooling in solid 3He and will be helpful
for investigating exotic quantum phases of SU(N) Hubbard system at extremely
low temperatures.Comment: 20 pages, 6 figures, to appear in Nature Physic
Caloric Curves and Nuclear Expansion
Nuclear caloric curves have been analyzed using an expanding Fermi gas
hypothesis to extract average nuclear densities. In this approach the observed
flattening of the caloric curves reflects progressively increasing expansion
with increasing excitation energy. This expansion results in a corresponding
decrease in the density and Fermi energy of the excited system. For nuclei of
medium to heavy mass apparent densities ~ 0.4 rho_0 are reached at the higher
excitation energies.Comment: 4 pages, 3 figure
Caloric curves and critical behavior in nuclei
Data from a number of different experimental measurements have been used to
construct caloric curves for five different regions of nuclear mass. These
curves are qualitatively similar and exhibit plateaus at the higher excitation
energies. The limiting temperatures represented by the plateaus decrease with
increasing nuclear mass and are in very good agreement with results of recent
calculations employing either a chiral symmetry model or the Gogny interaction.
This agreement strongly favors a soft equation of state. Evidence is presented
that critical excitation energies and critical temperatures for nuclei can be
determined over a large mass range when the mass variations inherent in many
caloric curve measurements are taken into account.Comment: In response to referees comments we have improved the discussion of
the figures and added a new figure showing the relationship between the
effective level density and the excitation energy. The discussion has been
reordered and comments are made on recent data which support the hypothesis
of a mass dependence of caloric curve
Erythropoietin (EPO) increases myelin gene expression in CG4 oligodendrocyte cells through the classical EPO receptor
Erythropoietin (EPO) has protective effects in neurodegenerative and neuroinflammatory diseases, including in animal models of multiple sclerosis, where EPO decreases disease severity. EPO also promotes neurogenesis and is protective in models of toxic demyelination. In this study, we asked whether EPO could promote neurorepair by also inducing remyelination. In addition, we investigated whether the effect of EPO could be mediated by the classical erythropoietic EPO receptor (EPOR), since it is still questioned if EPOR is functional in non-hematopoietic cells. Using CG4 cells, a line of rat oligodendrocyte precursor cells, we found that EPO increases the expression of myelin genes (myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP)). EPO had no effect in wild-type CG4 cells, which do not express EPOR, whereas it increased MOG and MBP expression in cells engineered to overexpress EPOR (CG4-EPOR). This was reflected in a marked increase in MOG protein levels, as detected by western blot. In these cells, EPO induced by 10-fold the early growth response gene 2 (Egr2), which is required for peripheral myelination. However, Egr2 silencing with a siRNA did not reverse the effect of EPO, indicating that EPO acts through other pathways. In conclusion, EPO induces the expression of myelin genes in oligodendrocytes and this effect requires the presence of EPOR. This study demonstrates that EPOR can mediate neuroreparative effects
Mamld1 Knockdown Reduces Testosterone Production and Cyp17a1 Expression in Mouse Leydig Tumor Cells
MAMLD1 is known to be a causative gene for hypospadias. Although previous studies have indicated that MAMLD1 mutations result in hypospadias primarily because of compromised testosterone production around the critical period for fetal sex development, the underlying mechanism(s) remains to be clarified. Furthermore, although functional studies have indicated a transactivation function of MAMLD1 for the non-canonical Notch target Hes3, its relevance to testosterone production remains unknown. To examine these matters, we performed Mamld1 knockdown experiments.Mamld1 knockdown was performed with two siRNAs, using mouse Leydig tumor cells (MLTCs). Mamld1 knockdown did not influence the concentrations of pregnenolone and progesterone but significantly reduced those of 17-OH pregnenolone, 17-OH progesterone, dehydroepiandrosterone, androstenedione, and testosterone in the culture media. Furthermore, Mamld1 knockdown significantly decreased Cyp17a1 expression, but did not affect expressions of other genes involved in testosterone biosynthesis as well as in insulin-like 3 production. Hes3 expression was not significantly altered. In addition, while 47 genes were significantly up-regulated (fold change >2.0Ă) and 38 genes were significantly down-regulated (fold change <0.5Ă), none of them was known to be involved in testosterone production. Cell proliferation analysis revealed no evidence for compromised proliferation of siRNA-transfected MLTCs.The results, in conjunction with the previous data, imply that Mamld1 enhances Cyp17a1 expression primarily in Leydig cells and permit to produce a sufficient amount of testosterone for male sex development, independently of the Hes3-related non-canonical Notch signaling
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