QP-Structures of Degree 3 and 4D Topological Field Theory

A A BV algebra and a QP-structure of degree 3 is formulated. A QP-structure of degree 3 gives rise to Lie algebroids up to homotopy and its algebraic and geometric structure is analyzed. A new algebroid is constructed, which derives a new topological field theory in 4 dimensions by the AKSZ construction.Comment: 17 pages, Some errors and typos have been correcte

Models of Dynamical Supersymmetry Breaking with Gauged U(1)RU(1)_R Symmetry

We present simple models of dynamical supersymmetry breaking with gauged U(1)_R symmetry. The minimal supersymmetric standard model and supersymmetric SU(5) GUT are considered as the visible sector. The anomaly cancellation conditions for U(1)_R are investigated in detail and simple solutions of the R-charge assignments are found. We show that this scenario of dynamical supersymmetry breaking is phenomenologically viable with the gravitino mass of order 1 TeV or 10 TeV.Comment: 15 pages, uses REVTEX macro, No figure

An Alternative Topological Field Theory of Generalized Complex Geometry

We propose a new topological field theory on generalized complex geometry in two dimension using AKSZ formulation. Zucchini's model is $A$ model in the case that the generalized complex structuredepends on only a symplectic structure. Our new model is $B$ model in the case that the generalized complex structure depends on only a complex structure.Comment: 29 pages, typos and references correcte

O(a)-improved quark action on anisotropic lattices and perturbative renormalization of heavy-light currents

We investigate the Symanzik improvement of the Wilson quark action on anisotropic lattices. Taking first a general action with nearest-neighbor and clover interactions, we study the mass dependence of the ratio of the hopping parameters, the clover coefficients, and an improvement coefficient for heavy-light vector and axial vector currents. We show how tree-level improvement can be achieved. For a particular choice of the spatial Wilson coupling, the results simplify, and $O(m_0a_\tau)$ improvement is possible. (Here $m_0$ is the bare quark mass and $a_\tau$ the temporal lattice spacing.) With this choice we calculate the renormalization factors of heavy-light bilinear operators at one-loop order of perturbation theory employing the standard plaquette gauge action.Comment: 26 pages, 8 figure

A Supersymmetric Composite Model with Dynamical Supersymmetry Breaking

We present a supersymmetric composite model with dynamical supersymmetry breaking. The model is based on the gauge group $SU(2)_S \times SU(2)_H \times SU(3)_c \times SU(2)_L \times U(1)_Y$. Supersymmetry is dynamically broken by the non-perturbative effect of the $SU(2)_S$ `supercolor' interaction. The large top Yukawa coupling is naturally generated by the $SU(2)_H$ `hypercolor' interaction as recently proposed by Nelson and Strassler. The supersymmetry breaking is mediated to the standard model sector by a new mechanism. The electroweak symmetry breaking is caused by the radiative correction due to the large top Yukawa coupling with the supersymmetry breaking. This is the `radiative breaking scenario', which originates from the dynamics of the supercolor and hypercolor gauge interactions.Comment: 30 pages, uses REVTEX macro, revised manuscript to appear in Phys. Rev.

Combination therapy with docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer: a retrospective analysis

<p>Abstract</p> <p>Background</p> <p>We performed a single-institution retrospective study to evaluate the efficacy and toxicities of combination therapy with docetaxel and S-1 in patients with advanced or recurrent gastric cancer.</p> <p>Methods</p> <p>Eighty-six patients with advanced or recurrent gastric cancer were enrolled. Patients received docetaxel, 40 mg/m², on day 1 and oral S-1, 80 mg/m²/day, on days 1 to 14 every 3 weeks.</p> <p>Results</p> <p>All 84 patients were assessable for response. The overall response rate was 52.4% (44/84) and the disease control rate was 96.4% (81/84). Median time to progression (TTP) and overall survival (OS) were 6.5 (95% CI, 4.8-8.1 months) and 15.1 months (95% CI, 11.7-18.5 months), respectively. The major toxicities were neutropenia, leukopenia, alopecia and anorexia. Grade 3 or 4 hematologic toxicities included neutropenia in 31 patients (36.0%), leukopenia in 27 (31.7%), febrile neutropenia in four (4.7%), and anemia in one (1.2%). Other grade 3 toxicities included anorexia in five patients (5.8%), and stomatitis, diarrhea and nausea in one each (1.2%). There was one treatment-related death (1.2%).</p> <p>Conclusion</p> <p>The combination of docetaxel and S-1 had good clinical activity with acceptable toxicity in patients with advanced or recurrent gastric cancer.</p

Spectroscopic evidence for a charge-density-wave condensate in a charge-ordered manganite: Observation of collective excitation mode in Pr0.7_{\text{0.7}}Ca0.3_{\text{0.3}}MnO3_{\text{3}} by using THz time-domain spectroscopy

THz time-domain spectroscopy was used to directly probe the low-energy (0.5--5 meV) electrodynamics of the charge-ordered manganite Pr$_{0.7}$Ca$_{0.3}$MnO$_3$. We revealed the existence of a finite peak structure around 2--3 meV well below the charge gap $\sim300$ meV. In analogy to the low-energy optical properties of the well-studied low-dimensional materials, we attributed this observed structure to the collective excitation mode arising from the charge-density-wave condensate. This finding provides the importance role of the quasi-one dimensional nature of the charge and orbital ordering in Pr$_{0.7}$Ca$_{0.3}$MnO$_3$.Comment: REVTeX4, 8 pages including 7 figures and 2 table

BNIP3 and NIX Mediate Mieap-Induced Accumulation of Lysosomal Proteins within Mitochondria

Mieap, a p53-inducible protein, controls mitochondrial quality by repairing unhealthy mitochondria. During repair, Mieap induces the accumulation of intramitochondrial lysosomal proteins (designated MALM for Mieap-induced accumulation of lysosome-like organelles within mitochondria) by interacting with NIX, leading to the elimination of oxidized mitochondrial proteins. Here, we report that an additional mitochondrial outer membrane protein, BNIP3, is also involved in MALM. BNIP3 interacts with Mieap in a reactive oxygen species (ROS)-dependent manner via the BH3 domain of BNIP3 and the coiled-coil domains of Mieap. The knockdown of endogenous BNIP3 expression severely inhibited MALM. Although the overexpression of either BNIP3 or NIX did not cause a remarkable change in the mitochondrial membrane potential (MMP), the co-expression of all three exogenous proteins, Mieap, BNIP3 and NIX, caused a dramatic reduction in MMP, implying that the physical interaction of Mieap, BNIP3 and NIX at the mitochondrial outer membrane may regulate the opening of a pore in the mitochondrial double membrane. This effect was not related to cell death. These results suggest that two mitochondrial outer membrane proteins, BNIP3 and NIX, mediate MALM in order to maintain mitochondrial integrity. The physical interaction of Mieap, BNIP3 and NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix

On Non-Chiral Extension of Kerr/CFT

We discuss possible non-chiral extension of the Kerr/CFT correspondence. We first consider the near horizon geometry of an extremal BTZ black hole and study the asymptotic symmetry. In order to define it properly, we introduce a regularization and show that the asymptotic symmetry becomes the desirable non-chiral Virasoro symmetry with the same central charges for both left and right sectors, which are independent of the regularization parameter. We then investigate the non-chiral extension for general extremal black holes in the zero entropy limit. Since the same geometric structure as above emerges in this limit, we identify non-chiral Virasoro symmetry by a similar procedure. This observation supports the existence of a hidden non-chiral CFT_2 structure with the same central charges for both left and right sectors dual to the rotating black holes.Comment: 29 pages, LaTeX; v2: minor corrections, references adde