40 research outputs found
Estudo inicial da degradação "in vitro" de poli (L-co-DL ácido lático) sintetizado em laboratório
Preparation and in vitro evaluation of biodegradable poly(epsilon-caprolactone-co-D,L lactide)(X-Y) devices containing trypanocidal drugs.
In vitro evaluation of poly(epsilon-caprolactone-co-L-lactide) implants containing trypanocidal drugs.
In vitro release of trypanocidal drugs from biodegradable implants based on poly(epsilon-caprolactone) and poly(D,L-lactide).
Biodegradable polyphosphazenes for drug delivery
Polyphosphazene derivatives having amino acid ester side groups were prepared by reaction of poly(dichlorophosphazene) with ethyl esters of amino acids. The in vitro degradation studies demonstrated that the rate of degradation depends on the nature of the amino acids. Introducing small amounts of hydrolytically sensitive groups such as depsipeptide ester or hydrolysis-catalysing moieties, such as histidine ethyl ester co-substituents, resulted in an increase of the degradation. The rate of hydrolytic degradation of the polyphosphazene material could be controlled by the content of the hydrolytically sensitive side groups or by blending hydrolysis-sensitive polymers with more stable derivatives. The results obtained from the in vivo implantation of biodegradable polyphosphazenes in mice indicate that the materials are very well tolerated by the animal body. Biodegradable polyphosphazenes have been used as matrix for the design of drug delivery systems. The rate of the in vitro release of mitomycin C from biodegradable polyphosphazenes can be controlled by changing the chemical composition of the polymer or by blending polymers of different chemical compositions