8 research outputs found
Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation
Chemical Immunolog
Proteasome degradative activity regulates CD8(+) T lymphocyte metabolism and fate specification
Bio-organic Synthesi
Proteasome degradative activity regulates CD8(+) T lymphocyte metabolism and fate specification
Chemical Immunolog
Proteasome activity regulates CD8(+) T lymphocyte metabolism and fate specification
Chemical Immunolog
Effects of crowding on the three main proteolytic mechanisms of skeletal muscle in rainbow trout (Oncorhynchus mykiss)
Inhibition of p38 Mitogen–Activated Protein Kinase Ameliorates HAP40 Depletion–Induced Toxicity and Proteasomal Defect in Huntington’s Disease Model
The proteasome system in health and disease.
The proteasome is involved in the regulation of all cellular pathways and consequently plays a central role in the control of cellular homeostasis. Together with its regulators, it is at the frontline, both as an actor and as a target, in human health and when homeostasis is disturbed in disease. In this review, we aim to provide an overview of the many levels at which the functions of the proteasome and its regulators can be regulated to cope with cellular needs or are altered in pathological conditions