Inverse association of colorectal cancer prevalence to serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in a large Appalachian population

Background Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent environmental contaminants that affect metabolic regulation, inflammation, and other factors implicated in the development and progression of colorectal cancer (CRC). However, the link between these compounds and CRC remains unknown. In this cross-sectional study, we investigated the association of CRC diagnosis to PFOA and PFOS blood levels in a large Appalachian population. Methods Participants were 47,359 adults ≥ 21 years of age and residing in six PFOA-contaminated water districts in the mid-Ohio Valley (N = 47,151 cancer-free adults, 208 cases of primary CRC). All participants completed a comprehensive health survey between 2005 and 2006; serum levels of PFOA, PFOS, and a range of other blood markers were also measured. Medical history was assessed via self report and cancer diagnosis confirmed via chart review. Results CRC showed a strong inverse, dose–response association with PFOS serum levels (odds ratio (OR) adjusted for potential confounders = 0.2, 95% confidence interval (CI) 0.2,0.3) for highest vs. lowest quartile of PFOS, P-trend \u3c 0.00001) and a significant, but more modest inverse association with PFOA (adjusted OR = 0.6 (CI 0.4, 0.9) for highest vs. lowest quartile, P-trend = 0.001). These inverse associations were stronger in those diagnosed within the previous 6 years and resident in the same water district for a minimum of 10–15 years preceding assessment. The relationship between PFOA and CRC was also more pronounced in men and leaner adults, and showed a stronger linear trend at lower exposure levels. Conclusions In this large cross-sectional study, we found a strong, inverse association between PFOS and likelihood of CRC diagnosis and a significant, although more modest inverse association between PFOA and CRC. If confirmed in prospective investigations, these findings may aid in identifying new strategies for CRC prevention and treatment and inform future studies regarding mechanisms underlying CRC pathogenesis

Experimental Investigation of the Continuous Transition of Flame-Spreading near the Blow-Off Limit

This study investigates the continuous transition from flame-spreading to stabilized combustion near the blow-off limit in opposed forced flow by using expanding solid fuel duct that makes distribution of oxidizer velocity in the axial direction. The stabilized combustion is a diffusion flame that appears in the Axial-Injection End-Burning Hybrid Rocket. The boundary between flame-spreading and stabilized combustion has not been investigated in detail. Polymethyl methacrylate (PMMA) rectangular ducts were used as a fuel, and gaseous oxygen was used as an oxidizer. All firing tests were conducted at atmospheric pressure. The diffusion flame traveled in the opposed-flow field where the oxidizer velocity increases continuously in the upstream direction. The combustion mode changed when oxidizer velocity at the flame tip exceeded a certain value. The oxidizer velocity used in this experiment ranges from 0.6 to 32.8 m/s. Experimental results show that a threshold oxidizer velocity of the transition can be determined. In this study, the threshold velocity was 26.4 m/s