Visual outcome of central serous retinopathy

Background: Central serous chorioretinopathy (CSCR) is a sporadic disorder of the outer blood retinal barrier. Increasing evidence implicates an abnormal choroidal circulation as the cause of CSCR. The study aimed at the visual outcome of central serous retinopathy for a duration of 6 months from the primary attack.Methods: Study conducted at Department of Ophthalmology in Out Patient Department of Mediciti Medical College Hospital, from June 2013 to December 2014. Total 30 patients’ eyes were treated with placebo treatment with antioxidants for a period of 6 months.Results: Highest prevalence of central serous retinopathy was seen in age group of 20-40 years in 26 eyes (85%), males are predominant i.e. out of 30 patients 27 (90%), risk factors of central serous retinopathy like Type A personality are observed in 3. Associated visual abnormalities like micropsia, central scotomas in 20% of patients, fluorescein angiography showed 60% inkblot pattern. After observation for 6 months visual acuity was spontaneously improved within 4-6 months in 70% of patients, recurrences was seen in 6 patients i.e. 20% is observed.Conclusions: Central serous retinopathy is most commonly seen among 20-40 years age group, with male predominance, unilateral in which Spontaneous resolution of central serous retinopathy is seen in 4-6 months so for which aggressive treatment is not necessary.

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead