Electric fields in plasmas under pulsed currents

Electric fields in a plasma that conducts a high-current pulse are measured as a function of time and space. The experiment is performed using a coaxial configuration, in which a current rising to 160 kA in 100 ns is conducted through a plasma that prefills the region between two coaxial electrodes. The electric field is determined using laser spectroscopy and line-shape analysis. Plasma doping allows for 3D spatially resolved measurements. The measured peak magnitude and propagation velocity of the electric field is found to match those of the Hall electric field, inferred from the magnetic-field front propagation measured previously.Comment: 13 pages, 13 figures, submitted to PR

Electron-wall interaction in Hall thrusters

Electron-wall interaction effects in Hall thrusters are studied through measurements of the plasma response to variations of the thruster channel width and the discharge voltage. The discharge voltage threshold is shown to separate two thruster regimes. Below this threshold, the electron energy gain is constant in the acceleration region and therefore, secondary electron emission (SEE) from the channel walls is insufficient to enhance electron energy losses at the channel walls. Above this voltage threshold, the maximum electron temperature saturates. This result seemingly agrees with predictions of the temperature saturation, which recent Hall thruster models explain as a transition to space-charge saturated regime of the near-wall sheath. However, in the experiment, the maximum saturation temperature exceeds by almost three times the critical value estimated under the assumption of a Maxwellian electron energy distribution function. The channel narrowing, which should also enhance electron-wall collisions, causes unexpectedly larger changes of the plasma potential distribution than does the increase of the electron temperature with the discharge voltage. An enhanced anomalous crossed-field mobility (near wall or Bohm-type) is suggested by a hydrodynamic model as an explanation to the reduced electric field measured inside a narrow channel. We found, however, no experimental evidence of a coupling between the maximum electron temperature and the location of the accelerating voltage drop, which might have been expected due to the SEE-induced near-wall conductivity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87763/2/057104_1.pd

The treatment of polycythaemia vera: an update in the JAK2 era

The clinical course of polycythaemia vera is marked by a high incidence of thrombotic complications, which represent the main cause of morbidity and mortality. Major predictors of vascular events are increasing age and previous thrombosis. Myelosuppressive drugs can reduce the rate of thrombosis, but there is concern that their use raises the risk of transformation into acute leukaemia. To tackle this dilemma, a risk-oriented management strategy is recommended. Low-risk patients should be treated with phlebotomy and low-dose aspirin. Cytotoxic therapy is indicated in high-risk patients, with the drug of choice being hydroxyurea because its leukaemogenicity is low. The recent discovery of JAK2 V617F mutation in the vast majority of polycythaemia vera patients opens new avenues for the treatment of this disease. Novel therapeutic options theoretically devoid of leukaemic risk, such as alpha-interferon and imatinib, affect JAK2 expression in some patients. Nevertheless, these drugs require further clinical experience and, for the time being, should be reserved for selected cases

Essential thrombocythemia

Essential thrombocythemia (ET) is an acquired myeloproliferative disorder (MPD) characterized by a sustained elevation of platelet number with a tendency for thrombosis and hemorrhage. The prevalence in the general population is approximately 30/100,000. The median age at diagnosis is 65 to 70 years, but the disease may occur at any age. The female to male ratio is about 2:1. The clinical picture is dominated by a predisposition to vascular occlusive events (involving the cerebrovascular, coronary and peripheral circulation) and hemorrhages. Some patients with ET are asymptomatic, others may experience vasomotor (headaches, visual disturbances, lightheadedness, atypical chest pain, distal paresthesias, erythromelalgia), thrombotic, or hemorrhagic disturbances. Arterial and venous thromboses, as well as platelet-mediated transient occlusions of the microcirculation and bleeding, represent the main risks for ET patients. Thromboses of large arteries represent a major cause of mortality associated with ET or can induce severe neurological, cardiac or peripheral artery manifestations. Acute leukemia or myelodysplasia represent only rare and frequently later-onset events. The molecular pathogenesis of ET, which leads to the overproduction of mature blood cells, is similar to that found in other clonal MPDs such as chronic myeloid leukemia, polycythemia vera and myelofibrosis with myeloid metaplasia of the spleen. Polycythemia vera, myelofibrosis with myeloid metaplasia of the spleen and ET are generally associated under the common denomination of Philadelphia (Ph)-negative MPDs. Despite the recent identification of the JAK2 V617F mutation in a subset of patients with Ph-negative MPDs, the detailed pathogenetic mechanism is still a matter of discussion. Therapeutic interventions in ET are limited to decisions concerning the introduction of anti-aggregation therapy and/or starting platelet cytoreduction. The therapeutic value of hydroxycarbamide and aspirin in high risk patients has been supported by controlled studies. Avoiding thromboreduction or opting for anagrelide to postpone the long-term side effects of hydrocarbamide in young or low risk patients represent alternative options. Life expectancy is almost normal and similar to that of a healthy population matched by age and sex

Relativistic Laser-Matter Interaction and Relativistic Laboratory Astrophysics

The paper is devoted to the prospects of using the laser radiation interaction with plasmas in the laboratory relativistic astrophysics context. We discuss the dimensionless parameters characterizing the processes in the laser and astrophysical plasmas and emphasize a similarity between the laser and astrophysical plasmas in the ultrarelativistic energy limit. In particular, we address basic mechanisms of the charged particle acceleration, the collisionless shock wave and magnetic reconnection and vortex dynamics properties relevant to the problem of ultrarelativistic particle acceleration.Comment: 58 pages, 19 figure

Control of the Electric Field Profile in the Hall Thruster

Control of the electric field profile in the Hall Thruster through the positioning of an additional electrode along the channel is shown theoretically to enhance the efficiency. The reduction of the potential drop near the anode by use of the additional electrode increases the plasma density there, through the increase of the electron and ion transit times, causing the ionization in the vicinity of the anode to increase. The resulting separation of the ionization and acceleration regions increases the propellant and energy utilizations. An abrupt sonic transition is forced to occur at the axial location of the additional electrode, accompanied by the generation of a large (theoretically infinite) electric field. This ability to generate a large electric field at a specific location along the channel, in addition to the ability to specify the electric potential there, allows one further control of the electric field profile in the thruster. In particular, when the electron temperature is high, a large abrupt voltage drop is induced at the vicinity of the additional electrode, a voltage drop that can comprise a significant part of the applied voltage