Autoimmune hepatitis triggered by nitrofurantoin: a case series

<p>Abstract</p> <p>Introduction</p> <p>Drugs can occasionally trigger the onset of autoimmune liver disease.</p> <p>Case presentation</p> <p>Three Caucasian women (aged 65, 42 and 74 years old) who were receiving long-term nitrofurantoin as prophylaxis against recurrent urinary tract infections developed hepatitic liver disease. Serological auto-antibody profiles and liver histology appearances were consistent with autoimmune hepatitis. Two of the patients presented with jaundice, and one required a prolonged hospital admission for liver failure. In all three patients nitrofurantoin was withdrawn, and long-term immunosuppressive therapy with prednisolone and azathioprine or mycophenolate was given. The patients responded well, with liver biochemistry returning to normal within a few months.</p> <p>Conclusions</p> <p>Although nitrofurantoin rarely causes autoimmune hepatitis, this antimicrobial is increasingly used as long-term prophylaxis against recurrent urinary tract infection. General practitioners and urologists who prescribe long-term nitrofurantoin therapy should be aware of this adverse effect.</p

Lipid Profile and Serum Characteristics of the Blind Subterranean Mole Rat, Spalax

to underground life resulted in structural and molecular-genetic differences comparing to above-ground mammals. These differences include higher myocardial maximal oxygen consumption, increased lung diffusion capacity, increased blood vessels density, and unique expression patterns of cancer and angiogenesis related genes such as heparanase, vascular endothelial growth factor, and P53. revealed special features in this mammal. pursue underground, dietary components, and evolutionary genetic adaptations. Unfolding the genetic basis of these differences will probably result in unique treatments for a variety of human diseases such as dyslipedemias, inflammation and cancer

Mitochondrial function after global cardiac ischemia and reperfusion: Influences of organelle isolation protocols

Dog hearts were made globally ischemic for 1 hr at normothermia, at 28°C, or at normothermia after perfusion with a hyperkalemic cardioplegia solution. After 1 hr of reperfusion mitochondria were isolated from each heart using three protocols involving: processing (homogenization and centrifugation) exclusively in KCl, Tris-EDTA plus albumin (KEA) solution; homogenizing in KEA but washing mitochondria in EDTA-depleted media (KA); or processing exclusively in EDTA-free medium.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41745/1/395_2005_Article_BF01907770.pd

The approach to a patient with acute polyuria and hypernatremia: a need for the physiology of McCance at the bedside.

GesondheidswetenskappeInterne GeneeskundePlease help us populate SUNScholar with the post print version of this article. It can be e-mailed to: [email protected]

Effects of propranolol on myocardial ultrastructure, mitochondrial function and high energy phosphates of isolated working rat hearts with coronary artery ligation

The effects of coronary artery ligation on myocardial ultrastructure, high energy phosphate contents and mitochondrial oxidative phosphorylation were studied in the isolated, perfused working rat heart model. The changes in ultrastructure, mitochondrial function and high energy phosphate contents of the ischaemic tissue were characteristic of severe ischaemic damage, showing a good correlation between ultrastructural and functional changes. To determine whether these changes could be prevented, reduced or delayed by beta-blockade, propranolol (3 x 10-7 and 3 x 10-6 M) was added to the perfusate. In our model propranolol did not exert a protective effect on the ultrastructure, tissue high energy phosphate contents and mitochondrial oxidative function except for a significant increase in QO2 (State 3) with propranolol at a concentration of 3 x 10-7 M.Articl

Inorganic phosphate inhibits sympathetic neurotransmission in canine saphenous veins

Inorganic phosphate has been proposed as the initiator of metabolic vasodilation in active skeletal muscle. The present study was primarily designed to determine if this substance has an inhibitory effect on adrenergic neurotransmission. Rings of canine saphenous veins were suspended for isometric tension recording in organ chambers. A comparison was made of the ability of inorganic phosphate (3 to 14 mM) to relax rings contracted to the same degree by electrical stimulation, exogenous norepinephrine, and prostaglandin F(2α). The relaxation during electrical stimulation was significantly greater at all concentrations of phosphate. In strips of saphenous veins previously incubated with [ 3H]norepinephrine, the depression of the contractile response caused by phosphate during electrical stimulation was accompanied by a significant reduction in the overflow of labeled neurotransmitter. Thus inorganic phosphate inhibits sympathetic neurotransmission and hence may have a key role in the sympatholysis in the active skeletal muscles during exercise. By contrast, in this preparation, it has a modest direct relaxing action on the vascular smooth muscle.link_to_subscribed_fulltex

Characterization of the pharmacological properties of tulobuterol

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Effect of inorganic phosphate on adrenergic neurotransmission in canine saphenous veins

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