2,211 research outputs found
The New Fat Higgs: Slimmer and More Attractive
In this paper we increase the MSSM tree level higgs mass bound to a value
that is naturally larger than the LEP-II search constraint by adding to the
superpotential a term, as in the NMSSM, and UV
completing with new strong dynamics {\it before} becomes
non-perturbative. Unlike other models of this type the higgs fields remain
elementary, alleviating the supersymmetric fine-tuning problem while
maintaining unification in a natural way.Comment: 14 pages and 2 figures. Added references and updated argument about
constraints from reheating temperatur
Analysis of location uncertainty for a microearthquake cluster: A case study
In many reservoirs, an increase in permeability and conductivity is achieved by hydraulic fracturing/stimulations which open cracks and fractures that then act as pathways for fluids to navigate in the subsurface. Mapping, localization, and general characterization of these fracture systems is of key importance in oil, gas, and geothermal energy production. The location of the microseismic events triggered during hydraulic fracturing or stimulation can help to characterize the properties of the fracture system. There are many different methods for localizing microearthquakes and, in general, these methods yield different locations, velocity models, and event origin times, due to differences in algorithms and input models. Here we focus on studying location confidence intervals associated with two localization methods, classical (triangulation) and Double-Difference, where uncertainties due to origin times can be marginalized away, thus decreasing uncertainties in the event locations. We relocate events using these two methods and three different velocity models. Of the two methods used here, Double-Difference produces smallest confidence regions. We also illustrate that, for our dataset in particular, marginalizing away the influence of the unknown origin times also improves the confidence intervals
Supersymmetry phenomenology beyond the MSSM after 5/fb of LHC data
We briefly review the status of motivated beyond-the-MSSM phenomenology in
the light of the LHC searches to date. In particular, we discuss the conceptual
consequences of the exclusion bounds, of the hint for a Higgs boson at about
125 GeV, and of interpreting the excess of direct CP violation in the charm
sector as a signal of New Physics. We try to go into the various topics in a
compact way while providing a relatively rich list of references, with
particular attention to the most recent developments.Comment: 20 pages + refs. v2: minor modifications, published versio
Pentagonal nanowires: a first-principles study of atomic and electronic structure
We performed an extensive first-principles study of nanowires in various
pentagonal structures by using pseudopotential plane wave method within the
density functional theory. Our results show that nanowires of different types
of elements, such as alkali, simple, transition and noble metals and inert gas
atoms, have a stable structure made from staggered pentagons with a linear
chain perpendicular to the planes of the pentagons and passing through their
centers. This structure exhibits bond angles close to those in the icosahedral
structure. However, silicon is found to be energetically more favorable in the
eclipsed pentagonal structure. These quasi one dimensional pentagonal nanowires
have higher cohesive energies than many other one dimensional structures and
hence may be realized experimentally. The effect of magnetic state are examined
by spin-polarized calculations. The origin of the stability are discussed by
examining optimized structural parameters, charge density and electronic band
structure, and by using analysis based on the empirical Lennard-Jones type
interaction. Electronic band structure of pentagonal wires of different
elements are discussed and their effects on quantum ballistic conductance are
mentioned. It is found that the pentagonal wire of silicon exhibits metallic
band structure.Comment: 4 figures, accepted for publication in Phys. Rev.
Models of Little Higgs and Electroweak Precision Tests
The little Higgs idea is an alternative to supersymmetry as a solution to the
gauge hierarchy problem. In this note, I review various little Higgs models and
their phenomenology with emphases on the precision electroweak constraints in
these models.Comment: 16 pages; 4 figures; review submitted to Modern Physics Letter
Ferroelectric Phase Transitions in Films with Depletion Charge
We consider ferroelectric phase transitions in both short-circuited and
biased ferroelectric-semiconductor films with a space (depletion) charge which
leads to some unusual behavior. It is shown that in the presence of the charge
the polarization separates into `switchable' and `non-switchable' parts. The
electric field, appearing due to the space charge, does not wash out the phase
transition, which remains second order but takes place at somewhat reduced
temperature. At the same time, it leads to a suppression of the
ferroelectricity in a near-electrode layer. This conclusion is valid for
materials with both second and first order phase transitions in pure bulk
samples. Influence of the depletion charge on thermodynamic coercive field
reduces mainly to the lowering of the phase transition temperature, and its
effect is negligible. The depletion charge can, however, facilitate an
appearance of the domain structure which would be detrimental for device
performance (fatigue). We discuss some issues of conceptual character, which
are generally known but were overlooked in previous works. The present results
have general implications for small systems with depletion charge.Comment: 11 pages, REVTeX 3.1, five eps-figures included in the text. Minor
clarifications in the text. To appear in Phys. Rev. B 61, Apr 1 (2000
Running into New Territory in SUSY Parameter Space
The LEP-II bound on the light Higgs mass rules out the vast majority of
parameter space left to the Minimal Supersymmetric Standard Model (MSSM) with
weak-scale soft-masses. This suggests the importance of exploring extensions of
the MSSM with non-minimal Higgs physics. In this article, we explore a theory
with an additional singlet superfield and an extended gauge sector. The theory
has a number of novel features compared to both the MSSM and Next-to-MSSM,
including easily realizing a light CP-even Higgs mass consistent with LEP-II
limits, tan(beta) < 1, and a lightest Higgs which is charged. These features
are achieved while remaining consistent with perturbative unification and
without large stop-masses. Discovery modes at the Tevatron and LHC are
discussed.Comment: 15 pages, 5 figures; Typo in equation (4.5) corrected; submitted to
JHE
Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer.
Transmembrane proteins MUC4, EGFR and HER2 are shown to be critical in invasion and metastasis of pancreatic cancer. Besides, we and others have demonstrated de novo expression of MUC4 in ~70-90% of pancreatic cancer patients and its stabilizing effects on HER2 downstream signaling in pancreatic cancer. Here, we found that use of canertinib or afatinib resulted in reduction of MUC4 and abrogation of in vitro and in vivo oncogenic functions of MUC4 in pancreatic cancer cells. Notably, silencing of EGFR family member in pancreatic cancer cells decreased MUC4 expression through reduced phospho-STAT1. Furthermore, canertinib and afatinib treatment also inhibited proliferation, migration and survival of pancreatic cancer cells by attenuation of signaling events including pERK1/2 (T202/Y204), cyclin D1, cyclin A, pFAK (Y925) and pAKT (Ser473). Using in vivo bioluminescent imaging, we demonstrated that canertinib treatment significantly reduced tumor burden (P=0.0164) and metastasis to various organs. Further, reduced expression of MUC4 and EGFR family members were confirmed in xenografts. Our results for the first time demonstrated the targeting of EGFR family members along with MUC4 by using pan-EGFR inhibitors. In conclusion, our studies will enhance the translational acquaintance of pan-EGFR inhibitors for combinational therapies to combat against lethal pancreatic cancer
Comparison of the CDC Backpack aspirator and the Prokopack aspirator for sampling indoor- and outdoor-resting mosquitoes in southern Tanzania.
BACKGROUND\ud
\ud
Resting mosquitoes can easily be collected using an aspirating device. The most commonly used mechanical aspirator is the CDC Backpack aspirator. Recently, a simple, and low-cost aspirator called the Prokopack has been devised and proved to have comparable performance. The following study evaluates the Prokopack aspirator compared to the CDC backpack aspirator when sampling resting mosquitoes in rural Tanzania.\ud
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METHODS\ud
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Mosquitoes were sampled in- and outdoors of 48 typical rural African households using both aspirators. The aspirators were rotated between collectors and households in a randomized, Latin Square design. Outdoor collections were performed using artificial resting places (large barrel and car tyre), underneath the outdoor kitchen (kibanda) roof and from a drop-net. Data were analysed with generalized linear models.\ud
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RESULTS\ud
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The number of mosquitoes collected using the CDC Backpack and the Prokopack aspirator were not significantly different both in- and outdoors (indoors p = 0.735; large barrel p = 0.867; car tyre p = 0.418; kibanda p = 0.519). The Prokopack was superior for sampling of drop-nets due to its smaller size. The number mosquitoes collected per technician was more consistent when using the Prokopack aspirator. The Prokopack was more user-friendly: technicians preferred using the it over the CDC backpack aspirator as it weighs considerably less, retains its charge for longer and is easier to manoeuvre.\ud
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CONCLUSIONS\ud
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The Prokopack proved in the field to be more advantageous than the CDC Backpack aspirator. It can be self assembled using simple, low-cost and easily attainable materials. This device is a useful tool for researchers or vector-control surveillance programs operating in rural Africa, as it is far simpler and quicker than traditional means of sampling resting mosquitoes. Further longitudinal evaluations of the Prokopack aspirator versus the gold standard pyrethrum spray catch for indoor resting catches are recommended
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