Is hyperbaric oxygen therapy a salvage treatment option for sudden sensorineural hearing loss?

Objective: To investigate of the efficacy of hyperbaric oxygen therapy as a salvage treatment after unsuccessful oral corticosteroid therapy

A case of sudden hearing loss associated with ANCA

A case of sudden hearing loss associated with ANCA. A 46-year-old female patient presented to our clinic with complaints of aural fullness and hearing loss for two days. On audiometric examination, she had sensorineural hearing loss in the left ear. Mean pure tone audiometry (PTA) was 53dB. Her medical history was significant for oral medication-controlled diabetes mellitus and chronic thyroiditis. Laboratory studies showed an erythrocyte sedimentation rate (ESR) of 40 mm/h and an anti-neutrophil cytoplasmic antibody directed against myeloperoxidase (MPO-ANCA) level of 33.1 EU/ml. ANCA-associated vasculitis was considered. The patient was started on immunosuppressive treatment. Seven months after the initial episode, the patient suffered a relapse. At 17 month follow-up after the initial event, the patient is healthy with normal hearing. Serum MPO-ANCA is within normal limits

Effect of septoplasty and per-operative antibiotic prophylaxis on nasal flora

Effect of septoplasty and per-operative antibiotic prophylaxis on nasal flora. Objectives: Septoplasty is one of the most commonly performed procedures in otolaryngology practice. Prophylactic use of antibiotics is controversial. Disruption of nasal flora may predispose individuals to infection. We investigated the effect of antibiotic prophylaxis and septoplasty on nasal flora

One and four layer acellular bladder matrix for fascial tissue reconstruction

To determine whether the use of multiple layers of acellular bladder matrix (ABM) is more suitable for the treatment of abdominal wall hernia than a single layered ABM. The feasibility, biocompatibility and mechanical properties of both materials were assessed and compared. Biocompatibility testing was performed on 4 and 1 layered ABM. The matrices were used to repair an abdominal hernia model in 24 rabbits. The animals were followed for up to 3 months. Immediately after euthanasia, the implant site was inspected and samples were retrieved for histology, scanning electron microscopy and biomechanical studies. Both acellular biomaterials demonstrated excellent biocompatibility. At the time of retrieval, there was no evidence of infection. The matrices demonstrated biomechanical properties comparable to native tissue. Three hernias (25%) were found in the single layer ABM group and only 1 hernia (8%) was found in the 4 layer ABM group. Histologically, the matrix structure was intact and the cell density within the matrices decreased with time. The dominant cell type present within the matrices shifted from lymphocytes to fibroblasts over time. Both ABMs maintained adequate strength over time when used for hernia repair, and there was an extremely low incidence of adhesion formation. The single layer ABM showed enhanced cellular integration, while the 4 layer ABM reduced hernia formation. Either of these matrices may be useful as an off-the-shelf biomaterial for patients requiring fascial repair