32 research outputs found
Role of PET/CT in patients with unexplained rising alpha fetoprotein post HCC interventional management
Targeted gene replacement in fungal pathogens via agrobacterium tumefaciens-mediated transformation
Review of the Mechanisms Involved in the Abscopal Effect and Future Directions with a Focus on Thymic Carcinoma
Optimization of in vitro regeneration and Agrobacterium tumefaciens-mediated transformation with heat-resistant cDNA in Brassica oleracea subsp. italica cv. Green Marvel
Frequency and genetic diversity of Blastocystis subtypes among patients attending to health centers in Mazandaran, northern Iran
Disruption of the Gene Which Encodes a Serodiagnostic Antigen and Chitinase of the Human Fungal Pathogen Coccidioides immitis
Novel stereotactic body radiation therapy (SBRT)-based partial tumor irradiation targeting hypoxic segment of bulky tumors (SBRT-PATHY): improvement of the radiotherapy outcome by exploiting the bystander and abscopal effects
Exploring the biology and evolution of Blastocystis and its role in the microbiome
Blastocystis is a microbial eukaryote, considered to be the most prevalent microbe colonizing the human gut, colonising approximately one billion individuals worldwide. Although Blastocystis presence has been linked to intestinal disorders, its pathogenicity still remains controversial due to its high prevalence in asymptomatic carriers. Having 17 genetic subtypes, Blastocystis is extremely diverse and can withstand fluctuations of oxygen in the gut. Blastocystis harbors peculiar mitochondrion-related organelles (MROs), which are considered to be an intermediate form between a typical aerobic mitochondrion and an obligate anaerobic hydrogenosome. Another interesting fact about Blastocystis concerns its mixed genome: 2.5% of the Blastocystis proteins have been laterally acquired from eukaryotes and prokaryotes. These acquired genes are associated with carbohydrate scavenging and metabolism, anaerobic amino acid and nitrogen metabolism, oxygen-stress resistance, and pH homeostasis. In addition, Blastocystis has proteins associated with secretion that are potentially involved in infection, escaping host defense and even affect composition of the prokaryotic microbiome and inflammation of the gut. In this chapter, we will challenge the state-of-the-art on Blastocystis knowledge, and we will present published data that can be used to understand the genomic adaptations of this microbial organism and its role within the microbiome of the hosts