10.4274/tjo.91249

Reversible posterior leukoencephalopathy syndrome is characterized by headache, nausea, seizures, altered consciousness, visual disturbance, and convulsion. It usually develops due to hypertension, eclampsia, autoimmune diseases, blood transfusion, hypercalcemia, hypomagnesemia, and immunosuppressive therapy. The radiological feature of this syndrome is reversible bilateral white matter abnormalities predominantly located in the posterior regions of the cerebral hemispheres. With symptomatic therapy, clinical and radiologic recovery can be achieved. In this case report, we aimed to present clinical and radiological findings of transient posterior leukoencephalopathy syndrome due to intrathecal methotrexate usage in a case with acute lymphoblastic leukemia. (Turk J Ophthalmol 2014; 44: 243-5

Effectiveness of Pyridoxine and Pyridostigmine in the Treatment of Vincristine-Induced Bilateral Ptosis and External Ophthalmoplegia: A Case Report

In this manuscript, we present the case of a patient with acute lymphoblastic leukemia who developed vincristine-induced bilateral ptosis and external ophthalmoplegia and who was treated successfully with pyridoxine and pyridostigmine. Pyridostigmine and pyridoxine are promising treatment option in cases of vincristine-induced neuropathy. (Turk J Ophthalmol 2014; 44: 330-1

Cerebral sinovenous thrombosis and multiple cranial palsies due to mature B-cell leukemia

Akut lenfoblastik lösemi çocukluk çağının en sık hematolojik malignensisidir. Sık semptomlar, inatçı ateş, ilerleyici solukluk, kanama, kilo kaybı, kemik ve eklem ağrılarıdır. Biz, serebral sinovenöz trombozisi ve çoklu kranial palsisi olan akut lenfoblastik lösemili bir çocuk rapor ettik. Sonuç olarak, ayakta tedavi edilen her hastanın nörolojik muayenesinin dikkatli yapılmasını tavsiye ediyoruz. Bu yaklaşım kuşkusuz ciddi hastalıkların sebep olduğu ağır nörolojik bulguları ortaya çıkaracaktır.Acute lymphoblastic leukemia is the most common hematological malignancy in childhood. Common presenting symptoms are persistent fever, progressive pallor, bleeding, weight loss, bone pains and joint symptoms. We report a child with acute lymphoblastic leukemia who presented multiple cranial palsies and cerebral sinovenous thrombosis. As a result, we advise a careful neurological examination for every outpatient. This approach will undoubtedly reveal severe neurological findings due to serious diseases

Cross-sectional study: long term follow-up care for pediatric cancer survivors in a developing country, Turkey: current status, challenges, and future perspectives

Aim: The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey. Material and methods: A questionnaire was e-mailed to the directors of 33 pediatric oncology centers (POCs) registered in the Turkish Pediatric Oncology Group (TPOG). Of these 33 active TPOG institutions, 21 participated in the study and returned their completed questionnaires. Results: Only 1 of the 21 participating centers had a separate LTFU clinic. The remaining centers provided LTFU care for childhood cancer survivors at the pediatric oncology outpatient clinic. Of these centers, 17 (80.9%) reported difficulty in transition from the pediatric clinic to the adult clinic, 14 (66.6%) reported insufficient care providers, and 12 (57.1%) reported insufficient time and transportation problems. As neglected late effects, 16 (76.1%) centers reported psychosocial and getty job problems and 11 (52.3%) reported sexual and cognitive problems. None of the centers had their own LTFU guidelines for their daily LTFU practice. Conclusion: This study was the first to gain an overview of the needs of POCs and the gaps in survivorship services in Turkey. The results from this study will help to develop a national health care system and national guidelines for pediatric cancer survivors