Association between Stargardt's disease and Retinitis Pigmentosa: Is common genetic mutation responsible? [Stargardt hastali?i ve Retinitis Pigmentosa birlikteli?i: Ortak genetik mutasyon mu sorumlu?]

In this study the association between Stargardt's disease (STGD) and Retinisitis Pigmentosa (RP), both of which is seen in a case with a mutated ABCA4 gene, is analysed. Fundus exaimination was performed to a 23 years old male whose dark vision are severely impaired and found beaten metal appearance on his right and left macula with bony specules in peripheral retina. Therefore fundus fluorescein angiography and electrophysiologic tests was performed to him. He was diagnosed with both STGD and RP based on clinical and diagnostic test findings. Genetic research of the patient revealed a mutation in ABCA4 gene. We consider that a possible association between STGD and RP in patients diagnosed with STGD or RP and that the major role of genetic research in diagnosis of retinal diseases should be kept in mind

Color stability and surface roughness of a laboratory-processed composite resin as a function of mouthrinse

Statement of the Problem Mouthrinses can cause discoloration on indirect resin composites. Purpose of the Study The purpose of the study was to investigate the effect of different mouthrinses on the color changes and surface roughness of a laboratory-processed composite. Methods and Materials Fifty discs were made using GC Gradia/GC indirect composites and divided into five groups which immersed in artificial saliva and four different types of mouthrinses. The samples were immersed daily for 14 days in 20mL of the solutions for 2 minutes twice a day (with a 12-hour interval between exposures). Measurements were carried out at four different times: 1 hour after sample preparation (t0), 1 day (t1), 7 days (t2), and 14 days (t3) after the first immersion in the solutions. The color before and after immersion was measured according to Comission Internationale de L'Eclairage (CIE L*, a*, b*) System and ?L*, ?a*, ?b*, and ?E* values were calculated. The surface roughness Ra (µm) of the specimens was evaluated using a profilometer. Results There were significant differences between the groups at all time representing ?E values (p<0.001). At (t1) time representing ?Ra value, there were significant differences between the groups (p<0.05). At (t2, t3) time representing ?Ra values, there were significant differences between the groups (p<0.001). Pharmol Zn immersed specimens showed ?E values between 1.04 and 3.67. Conclusions The result of this study indicated that the mouthrinses affected the color stability of indirect composites. Clinical Significance Based on the results of this study, patients with resin composite restorations should be warned by the dentists about the discoloration of the restorations and the time period of the mouthrinse that will be used. © 2015 Wiley Periodicals, Inc

Results of intravitreal ranibizumab treatment for choroidal neovascularization secondary to age-related macular degeneration [Yaşa ba?li maküla dejenerasyonuna i?kincil gelişen koroid neovaskülarizasyonlarinda i?ntravitreal ranibizumab tedavi sonuçlarimiz]

Purpose: To report the efficacy and results of intravitreal ranibizumab (IVR) injection for choroidal neovascularization due to age-related macular degeneration (ARMD). Materials and Methods: Fifty-eight eyes of 43 ARMD patients received 287 injections of 0.5 mg/0.05 mL IVR and were followed up for at least one year prospectively. The mean age was 67.64 ± 8.14. All patients received three consecutive monthly IVR injections. IVR injections were readministered based on visual acuity (VA) measurements, fundus fluorescein angiography (FFA), and optic coherence tomography (OCT) results. Results: By three months, 28 eyes (48.3%) had an increase in VA of 5 letters or more, 27 eyes (46.5%) had no change, and 3 eyes (5.2%) had a decrease of 5 letters or more. After the 12-month follow-up VA results were as follows: 26 eyes (44.8%) had an increase of 5 letters or more, 28 eyes (48.3%) had no change, and 4 eyes (6.9%) had a decrease of 5 letters or more. In 44 eyes (75.9%), central macular thickness (CMT) decreased by 100 ?m or more, in 12 eyes (20.7%) there was no change, and in 2 eyes (3.4%) CMT increased by 100 ?m or more at the third month. After the 12-month follow-up, CMT decreased by 100 ?m or more in 42 eyes (72.4%) and increased by 100 ?m or more in 3 eyes (5.2%), while 13 eyes (22.4%) had no change. Conclusions: IVR provides significant anatomic and functional improvement compared the baseline in choroidal neovascularization due to ARMD