1 research outputs found
Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD
Enterovirus 71 (EV71)
is a major causative agent of hand, foot,
and mouth disease (HFMD), which can spread its infections to the central
nervous and other systems with severe consequences. The viral caspid
protein VP1 is a well-known target for antiviral efficacy because
its occupancy by suitable compounds could stabilize the virus capsid,
thus preventing uncoating of virus for RNA release. In this Letter,
design, synthesis, and biological evaluation of novel anti-EV71 agents
(aminopyridyl 1,2,5-thiadiazolidine 1,1-dioxides) are described. One
of the most promising compounds (<b>14</b>) showed excellent
antiviral activity against EV71 (EC<sub>50</sub> = 4 nM) and exhibited
excellent <i>in vivo</i> efficacy in the EV71 infected mouse
model