111 research outputs found
Melatonin reverses type 2 diabetes-induced cognitive deficits via attenuation of oxidative/nitrosative stress and NF-κB-mediated neuroinflammation in rat hippocampus
Purpose: To evaluate the protective effect of melatonin on diabetes-induced cognitive dysfunction. Methods: Rats were fed a high-fat diet + streptozotocin (HFD + STZ) for 15 weeks to induce type 2 diabetes (HFD + STZ group). At the end of the 15-week induction of diabetes, cognitive function in the diabetic rats was estimated using a Morris water maze and an object recognition task. Next, the diabetic rats were treated with melatonin (10 mg/ kg, po) for 3 weeks. Thereafter, cognitive function was reevaluated in the melatonin-treated diabetic rats (melatonin group). Results: There was a significant (p < 0.01) decrease in the serum glucose and insulin in melatonintreated diabetes type 2 rats compared with that of diabetes type 2 rats exposed to only HFD + STZ. Treatment with melatonin (10 mg/kg, po) for 3 weeks in diabetic type 2 rats also caused a significant increase (p < 0.01) in the time spent in the target quadrant and preference index in diabetic rats compared with the HFD + STZ group. There were significant decreases in reactive oxygen species (ROS), oxido-nitrosative stress markers, including thiobarbituric acid reactive substances (TBARS), nitrite, and depleted glutathione (GSH) level in the hippocampus of melatonin-treated group, compared with the HFD + STZ-treated group. Moreover, the melatonin-treated group showed significant inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and reduction in the levels of proinflammatory cytokines. Conclusion: The results demonstrate that melatonin prevents cognitive dysfunction in type 2 diabetic rats by attenuating oxido-nitrosative stress and NF-κB-mediated neuroinflammation. This effect suggests that melatonin may be useful for the management of cognitive dysfunction in patients suffering from diabetes. Keywords: Cognitive dysfunction, Melatonin, Neuroinflammation, Nuclear factor kappa-light-chainenhancer of activated B cells (NF-κB), Oxido-nitrosative stress, Type 2 diabete
Impaired function of dendritic cells within the tumor microenvironment
Dendritic cells (DCs), a class of professional antigen-presenting cells, are considered key factors in the initiation and maintenance of anti-tumor immunity due to their powerful ability to present antigen and stimulate T-cell responses. The important role of DCs in controlling tumor growth and mediating potent anti-tumor immunity has been demonstrated in various cancer models. Accordingly, the infiltration of stimulatory DCs positively correlates with the prognosis and response to immunotherapy in a variety of solid tumors. However, accumulating evidence indicates that DCs exhibit a significantly dysfunctional state, ultimately leading to an impaired anti-tumor immune response due to the effects of the immunosuppressive tumor microenvironment (TME). Currently, numerous preclinical and clinical studies are exploring immunotherapeutic strategies to better control tumors by restoring or enhancing the activity of DCs in tumors, such as the popular DC-based vaccines. In this review, an overview of the role of DCs in controlling tumor progression is provided, followed by a summary of the current advances in understanding the mechanisms by which the TME affects the normal function of DCs, and concluding with a brief discussion of current strategies for DC-based tumor immunotherapy
Precise Measurements of Branching Fractions for Meson Decays to Two Pseudoscalar Mesons
We measure the branching fractions for seven two-body decays to
pseudo-scalar mesons, by analyzing data collected at
GeV with the BESIII detector at the BEPCII collider. The branching fractions
are determined to be ,
,
,
,
,
,
,
where the first uncertainties are statistical, the second are systematic, and
the third are from external input branching fraction of the normalization mode
. Precision of our measurements is significantly improved
compared with that of the current world average values
Conservation and diversification of the miR166 family in soybean and potential roles of newly identified miR166s
Measurement of the cross section of at center-of-mass energies between 3.510 and 4.843 GeV
Using collision data corresponding to a total integrated luminosity
of 12.9 collected with the BESIII detector at the BEPCII collider,
the exclusive Born cross sections and the effective form factors of the
reaction are measured via the single
baryon-tag method at 23 center-of-mass energies between 3.510 and 4.843 GeV.
Evidence for the decay is observed
with a significance of 4.5 by analyzing the measured cross sections
together with earlier BESIII results. For the other charmonium(-like) states
, , , , , and ,
no significant signal of their decay to is found. For these
states, upper limits of the products of the branching fraction and the
electronic partial width at the 90% confidence level are provided.Comment: 18 pages, 10 pages, 4 table
Amplitude analysis and branching fraction measurement of the decay
Using 2.93 of collision data collected with the
BESIII detector at the center-of-mass energy 3.773\,GeV, we perform the first
amplitude analysis of the decay and determine the
relative magnitudes and phases of different intermediate processes. The
absolute branching fraction of is measured to be
. The dominant intermediate
processes are and , with branching fractions of and , respectively
A coupled-channel analysis of the lineshape with BESIII data
We perform a study of the lineshape using the data samples of
, and collected with the BESIII detector. The effects of the coupled-channels
and the off-shell are included in the parameterization of the
lineshape. The lineshape mass parameter is obtained to be MeV. Two poles are found on the first and second Riemann
sheets corresponding to the branch cut. The pole location on
the first sheet is much closer to the threshold than the
other, and is determined to be MeV above the
threshold with an imaginary part
MeV
Measurement of branching fractions of decays to , and
Based on 4.5 fb data taken at seven center-of-mass energies ranging
from 4.600 to 4.699 GeV with the BESIII detector at the BEPCII collider, we
measure the branching fractions of
relative to
. Combining with the world
average branching fraction of , their branching fractions are measured to be
for , for
,
for
and
for
(non-). In all the above
results, the first uncertainties are statistical, the second are systematic and
the third are from external input of the branching fraction of
. Since no signal for
is observed, the
upper limit of its branching fraction is determined to be 0.11\% at the 90
confidence level
Observation of the Singly Cabibbo-Suppressed Decay
The singly Cabibbo-suppressed decay is observed for the first time with a statistical
significance of by using 4.5 fb of collision data
collected at center-of-mass energies between 4.600 and 4.699 GeV with the
BESIII detector at BEPCII. The absolute branching fraction of
is measured to be in a model-independent approach. This is
the first observation of a Cabibbo-suppressed decay involving
in the final state. The ratio of branching fractions between
and the Cabibbo-favored decay
is calculated to be , where with the
Cabibbo mixing angle. This ratio significantly deviates from and
provides important information for the understanding of nonfactorization
contributions in decays.Comment: 8 pages, 2 figure
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