2 research outputs found
Total Synthesis of Nannocystin A
Nannocystin A is
a 21-membered cyclodepsipeptide showing remarkable
anticancer properties. Described is the total synthesis of nannocystin
A, which features an asymmetric vinylogous Mukaiyama aldol reaction
for efficient assembly of the penultimate open-chain precursor and
a pivotal intramolecular Heck cross-coupling for the final macrocyclization
Total Synthesis of Nannocystin A
Nannocystin A is
a 21-membered cyclodepsipeptide showing remarkable
anticancer properties. Described is the total synthesis of nannocystin
A, which features an asymmetric vinylogous Mukaiyama aldol reaction
for efficient assembly of the penultimate open-chain precursor and
a pivotal intramolecular Heck cross-coupling for the final macrocyclization