2 research outputs found
Additional file 1 of Molecular mechanism of Danshenol C in reversing peritoneal fibrosis: novel network pharmacological analysis and biological validation
Additional file 1
Surface Modification with ECM-Inspired SDF-1α/Laminin-Loaded Nanocoating for Vascular Wound Healing
Surface
biomimetic modification with extra-cellular matrix (ECM)-derived biomolecules
is an emerging potential method of accelerating the healing of vascular
stent lesions. However, insufficient capacity of the constructed biofunctional
layer in maintaining its long-term efficiency and preventing thrombus
and neointimal hyperplasia continue to be major limitations in clinical
application. On the basis of the structure and function of ECM, in
this study, we constructed a novel stromal cell-derived factor-1α
(SDF-1α)/laminin-loaded nanocoating on the 316L stainless steel
(SS) surface to provide improved function in modulation of vascular
remodeling. The modified surface was found to control delivery of
biomolecules and exhibit promising potential to provide stage-adjusted
treatment after injury. An <i>in vitro</i> biocompatibility
study suggested that the constructed layer may effectively prevent
thrombosis formation by inhibiting platelet adhesion and activation,
while accelerating endothelium regeneration by inducing endothelial
cell (EC) migration and endothelial progenitor cell (EPC) aggregation.
An <i>in vivo</i> animal test further demonstrated that
the nanocoating may prevent thrombus and neointimal hyperplasia after
implantation for 3 months. Therefore, the ECM-inspired nanocoating
described in this study is a promising novel approach for vascular
stent surface modification