6 research outputs found
Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against Ischemia/Reperfusion Injury
Ischemic preconditioning (IPC) or postconditioning (Ipost) is proved to efficiently prevent ischemia/reperfusion injuries. Mortality of diabetic patients with acute myocardial infarction was found to be 2–6 folds higher than that of non-diabetic patients with same myocardial infarction, which may be in part due to diabetic inhibition of IPC- and Ipost-mediated protective mechanisms. Both IPC- and Ipost-mediated myocardial protection is predominantly mediated by stimulating PI3K/Akt and associated GSK-3β pathway while diabetes-mediated pathogenic effects are found to be mediated by inhibiting PI3K/Akt and associated GSK-3β pathway. Therefore, this review briefly introduced the general features of IPC- and Ipost-mediated myocardial protection and the general pathogenic effects of diabetes on the myocardium. We have collected experimental evidence that indicates the diabetic inhibition of IPC- and Ipost-mediated myocardial protection. Increasing evidence implies that diabetic inhibition of IPC- and Ipost-mediated myocardial protection may be mediated by inhibiting PI3K/Akt and associated GSK-3β pathway. Therefore any strategy to activate PI3K/Akt and associated GSK-3β pathway to release the diabetic inhibition of both IPC and Ipost-mediated myocardial protection may provide the protective effect against ischemia/reperfusion injuries
Research on Real Working Condition Simulation and Performance Test of Wind Power Main Bearing Based on Test Bench
As a renewable energy source, wind energy has received more and more attention, and the wind power industry has also been advocated and developed by countries all over the world. In the production and use of wind turbines, the design and manufacturing technology of wind turbine bearings is very important. In order to ensure the reliable operation of the wind power main bearing after installation and realize the longest life of it, this paper designs a bearing test bench that can test the performance of the wind power main bearing. It can analyze the temperature, displacement, load, and moment of the key parts of the 5 MW wind power main shaft bearing. The solid modeling of the experimental platform was carried out using the 3D modeling software SolidWorks. Hydraulic loading system and test monitoring system are designed to realize the drive and control of the test bench. Through the established mathematical model, the central load of the hub is converted into the axial cylinder load and the radial cylinder load of the test bench to simulate the actual working conditions of the tested bearing. The test results show that the test bench meets various loading requirements and can reliably complete the task of testing wind power main bearings
Oral Administration of Prunella vulgaris L Improves the Effect of Taxane on Preventing the Progression of Breast Cancer and Reduces Its Side Effects
<sup>99m</sup>Tc-HisoDGR as a Potential SPECT Probe for Orthotopic Glioma Detection via Targeting of Integrin α<sub>5</sub>β<sub>1</sub>
Integrins,
a large family of cell adhesion receptors, have been
shown to play an important role for glioma proliferation and invasion.
Several integrin receptors, including α<sub>v</sub>β<sub>3</sub>, α<sub>v</sub>β<sub>5</sub>, and α<sub>5</sub>β<sub>1</sub>, have generated clinical interest for
glioma diagnosis and antitumor therapy. Integrin α<sub>5</sub>β<sub>1</sub> has been highlighted as a prognostic and diagnostic
marker in glioma, and its expression is correlated with a worse prognosis
in high-grade glioma. However, unlike extensively studied integrins
α<sub>v</sub>β<sub>3</sub> and α<sub>v</sub>β<sub>5</sub>, very few integrin α<sub>5</sub>β<sub>1</sub>-specific radiotracers have been reported. Developing α<sub>5</sub>β<sub>1</sub>-specific radiotracers may provide alternative
diagnosis and evaluation options in addition to well-studied α<sub>v</sub>β<sub>3</sub>/α<sub>v</sub>β<sub>5</sub>-specific tracers, and they may add new documents for profiling tumor
progression. Here, a novel integrin α<sub>5</sub>β<sub>1</sub>-specific probe <sup>99m</sup>Tc-HisoDGR was fabricated for
SPECT (single-photon emission computed tomography) imaging of glioma.
To confirm its selective targeting of integrin α<sub>5</sub>β<sub>1</sub> in vivo, the mouse models of α<sub>5</sub>β<sub>1</sub>-positive U87MG human glioma were subjected to
SPECT/CT scans, and biodistribution experiments and blocking studies
were performed. Small-animal SPECT/CT imaging experiments demonstrated
that the tumors were clearly visualized in both subcutaneous and orthotopic
glioma tumor models with clear background at 0.5, 1, and 2 h p.i.
The tumor accumulation of <sup>99m</sup>Tc-HisoDGR showed significant
reduction when excess cold isoDGR peptide was coinjected, suggesting
that the tumor uptake was specifically mediated. Our work revealed
that <sup>99m</sup>Tc-HisoDGR represented a powerful molecular probe
for integrin α<sub>5</sub>β<sub>1</sub>-positive cancer
imaging; moreover, it might be a promising tool for evaluating malignancy,
predicting prognosis, selecting subpopulations of patients who might
be sensitive to integrin α<sub>5</sub>β<sub>1</sub>-targeted
drugs, and assessing and monitoring the response to integrin α<sub>5</sub>β<sub>1</sub>-targeted drugs in clinical trials
Manipulating Peierls Distortion in van der Waals NbOX<sub>2</sub> Maximizes Second-Harmonic Generation
Two-dimensional (2D) van der Waals (vdW) materials, featuring
relaxed
phase-matching conditions and highly tunable optical nonlinearity,
endow them with potential applications in nanoscale nonlinear optical
(NLO) devices. Despite significant progress, fundamental questions
in 2D NLO materials remain, such as how structural distortion affects
second-order NLO properties, which call for advanced regulation and in situ diagnostic tools. Here, by applying pressure to
continuously tune the displacement of Nb atoms in 2D vdW NbOI2, we effectively modulate the polarization and achieve a 3-fold
boost of the second-harmonic generation (SHG) at 2.5 GPa. By introducing
a Peierls distortion parameter, λ, we establish a quantitative
relationship between λ and SHG intensity. Importantly, we further
demonstrate that the SHG enhancement can be achieved under ambient
conditions by anionic substitution to tune the distortion in NbO(I1–xBrx)2 (x = 0–1) compounds, where the chemical
tailoring simulates the pressure effects on the structural optimization.
Consequently, NbO(I0.60Br0.40)2 with
λ = 0.17 exhibits a giant SHG of over 2 orders of magnitude
higher than that in monolayer WSe2, reaching the record-high
value among reported 2D vdW NLO materials. This work unambiguously
demonstrates the correlation between Peierls distortion and SHG property
and, more broadly, opens new paths for the development of advanced
NLO materials by manipulating the structure distortions