Lift-Based Bidding in Ad Selection

Real-time bidding (RTB) has become one of the largest online advertising markets in the world. Today the bid price per ad impression is typically decided by the expected value of how it can lead to a desired action event (e.g., registering an account or placing a purchase order) to the advertiser. However, this industry standard approach to decide the bid price does not consider the actual effect of the ad shown to the user, which should be measured based on the performance lift among users who have been or have not been exposed to a certain treatment of ads. In this paper, we propose a new bidding strategy and prove that if the bid price is decided based on the performance lift rather than absolute performance value, advertisers can actually gain more action events. We describe the modeling methodology to predict the performance lift and demonstrate the actual performance gain through blind A/B test with real ad campaigns in an industry-leading Demand-Side Platform (DSP). We also discuss the relationship between attribution models and bidding strategies. We prove that, to move the DSPs to bid based on performance lift, they should be rewarded according to the relative performance lift they contribute.Comment: AAAI 201

Alterations in cellular metabolism under different grades of glioma staging identified based on a multi-omics analysis strategy

Glioma is a type of brain tumor closely related to abnormal cell metabolism. Firstly, multiple combinatorial sequencing studies have revealed this relationship. Genomic studies have identified gene mutations and gene expression disorders related to the development of gliomas, which affect cell metabolic pathways. In addition, transcriptome studies have revealed the genes and regulatory networks that regulate cell metabolism in glioma tissues. Metabonomics studies have shown that the metabolic pathway of glioma cells has changed, indicating their distinct energy and nutritional requirements. This paper focuses on the retrospective analysis of multiple groups combined with sequencing to analyze the changes in various metabolites during metabolism in patients with glioma. Finally, the changes in genes, regulatory networks, and metabolic pathways regulating cell metabolism in patients with glioma under different metabolic conditions were discussed. It is also proposed that multi-group metabolic analysis is expected to better understand the mechanism of abnormal metabolism of gliomas and provide more personalized methods and guidance for early diagnosis, treatment, and prognosis evaluation of gliomas

Multimedia Teaching Platform for Urban Planning Utilizing 3D Technology

In recent years, 3D technology based on computer and internet has achieved high-speed development. People have realized direct and stereo observation of realistic world. Three-dimensional and visualized characteristics of the technology fit well with the teaching objective of college architecture specialized courses. Thus, 3D model has profound practical significance for its application in urban green space system and urban rural overall planning. With “urban-rural master plan” as experimental course, through design of “urban-rural master plan” multimedia teaching platform based on 3D technology and practice of the teaching platform in course teaching, this article has applied control experiment method and statistical method to make comparative analysis on the teaching effect difference of multimedia teaching platform based on 3D technology application in “urban-rural master plan” as experimental course so as to provide theoretical and data support for 3D technology application in “urban-rural master plan” and other college architecture major courses

Preparation of a Ni-P-nanoPTFE Composite Coating on the Surface of GCr15 Steel for Spinning Rings via a Defoamer and Transition Layer and Its Wear and Corrosion Resistance

In this study, a method of preparing a Ni-P-nanoPTFE composite coating on the surface of GCr15 steel for spinning rings is proposed. The method incorporates a defoamer into the plating solution to inhibit the agglomeration of nano-PTFE particles and pre-deposits a Ni-P transition layer to reduce the possibility of leakage coating. Meanwhile, the effect of varying the PTFE emulsion content in the bath on the micromorphology, hardness, deposition rate, crystal structure, and PTFE content of the composite coatings was investigated. The wear and corrosion resistances of the GCr15 substrate, Ni-P coating, and Ni-P-nanoPTFE composite coating are compared. The results show that the composite coating prepared at a PTFE emulsion concentration of 8 mL/L has the highest concentration of PTFE particles (up to 2.16 wt%). Additionally, its wear resistance and corrosion resistance are improved compared with Ni-P coating. The friction and wear study shows that the nano-PTFE particles with low dynamic friction coefficient are mixed in the grinding chip, which gives the composite coating self-lubricating characteristics, and the friction coefficient decreases to 0.3 compared with 0.4 of Ni-P coating. The corrosion study shows that the corrosion potential of the composite coating has increased by 7.6% compared with that of the Ni-P coating, which shifts from −456 mV to a more positive value of −421 mV. The corrosion current reduces from 6.71 μA to 1.54 μA, which is a 77% reduction. Meanwhile, the impedance increased from 5504 Ω·cm2 to 36,440 Ω·cm2, which is an increase of 562%

Spin transport properties of T-phase VSe2 2D materials based on eight-atom-ring line defects

Defects play a crucial role in modulating the properties of solid-state materials by inducing localized states that often benefit magnetic moments. Recently, direct experimental observations have shown the appearance of bunches of eight-atom-ring line defects in the T-phase VSe2 monolayer, a remarkable room-temperature two-dimensional magnetic metal. Using first-principles calculations, we have found that these line defects could enhance the magnetic moments, and half-metallicity (nearly 100% spin polarization) can be achieved in the structure with the densest defects. Furthermore, our analysis of the partial charge density distribution shows that a closer inter-defect distance between the d-states of vanadium atoms and p-states of selenium atoms increases the penalty of electrons occupying the spin-minority states. Moreover, we have discovered the high conductivity channel exhibits negative differential resistance characteristics within a bias range of 0.2 to 0.4 V (–0.4 to –0.2 V). Our findings broaden the scope of the applications of two-dimensional materials in spintronics and provide some theoretical guidance for the design of high-performance spintronic devices

Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3

The MDM2-p53 pathway has a prominent oncogenic function in the pathogenesis of various cancers. Nutlin-3, a small-molecule antagonist of MDM2-p53 interaction, inhibits proliferation in cancer cells with wild-type p53. Herein, we evaluate the expression of MDM2, both the full length and a splicing variant MDM2-A, and the sensitivity of Nutlin-3 in different cancer cell lines. Included are seven cell lines with wild-type p53 (four mesothelioma, one breast cancer, one chondrosarcoma, and one leiomyosarcoma), two liposarcoma cell lines harboring MDM2 amplification and wild-type p53, and one mesothelioma cell line harboring a p53 point mutation. Nutlin-3 treatment increased expression of cyclin D1, MDM2, and p53 in cell lines with wild-type p53. Additive effects were observed in cells containing wild-type p53 through coordinated attack on MDM2-p53 binding and cyclin D1 by lentivirual shRNA knockdown or small molecule inhibition, as demonstrated by immunoblots and cell viability analyses. Further results demonstrate that MDM2 binds to cyclin D1, and that an increase in cyclin D1 expression after Nutlin-3 treatment is correlated with expression and ubiquitin E3-ligase activity of MDM2. MDM2 and p53 knockdown experiments demonstrated inhibition of cyclin D1 by MDM2 but not p53. These results indicate that combination inhibition of cyclin D1 and MDM2-p53 binding warrants clinical evaluation as a novel therapeutic strategy in cancer cells harboring wild-type p53