3 research outputs found
High-Throughput Screening and Confirmation of 22 Banned Veterinary Drugs in Feedstuffs Using LC-MS/MS and High-Resolution Orbitrap Mass Spectrometry
A new
analytical strategy based on liquid chromatography–tandem
mass spectrometry (LC-MS/MS) combined with accurate mass high-resolution
Orbitrap mass spectrometry (HR-Orbitrap MS) was performed for high-throughput
screening, confirmation, and quantification of 22 banned or unauthorized
veterinary drugs in feedstuffs according to Bulletin 235 of the Ministry
of Agriculture, China. Feed samples were extracted with acidified
acetonitrile, followed by cleanup using solid-phase extraction cartridge.
The extracts were first screened by LC-MS/MS in a single selected
reaction monitoring mode. The suspected positive samples were subjected
to a specific pretreatment for confirmation and quantification of
analyte of interest with LC-MS/MS and HR-Orbitrap MS. Mean recoveries
for all target analytes (except for carbofuran and chlordimeform,
which were about 35 and 45%, respectively) ranged from 52.2 to 90.4%,
and the relative standard deviations were <15% except for 20% for
carbofuran. The decision limits (CCαs) for target analytes in
formulated feed were between 2.6 and 23 μg/kg, and the detection
capabilities (CCβs) were between 4.2 and 34 μg/kg. The
method was successfully applied to screening of real samples obtained
from local feed markets and confirmation of the suspected target analytes.
It provides a high-throughput, sensitive, and reliable screening,
identification, and quantification of banned veterinary drugs in routine
monitoring programs of feedstuffs
High-Throughput Screening and Confirmation of 22 Banned Veterinary Drugs in Feedstuffs Using LC-MS/MS and High-Resolution Orbitrap Mass Spectrometry
A new
analytical strategy based on liquid chromatography–tandem
mass spectrometry (LC-MS/MS) combined with accurate mass high-resolution
Orbitrap mass spectrometry (HR-Orbitrap MS) was performed for high-throughput
screening, confirmation, and quantification of 22 banned or unauthorized
veterinary drugs in feedstuffs according to Bulletin 235 of the Ministry
of Agriculture, China. Feed samples were extracted with acidified
acetonitrile, followed by cleanup using solid-phase extraction cartridge.
The extracts were first screened by LC-MS/MS in a single selected
reaction monitoring mode. The suspected positive samples were subjected
to a specific pretreatment for confirmation and quantification of
analyte of interest with LC-MS/MS and HR-Orbitrap MS. Mean recoveries
for all target analytes (except for carbofuran and chlordimeform,
which were about 35 and 45%, respectively) ranged from 52.2 to 90.4%,
and the relative standard deviations were <15% except for 20% for
carbofuran. The decision limits (CCαs) for target analytes in
formulated feed were between 2.6 and 23 μg/kg, and the detection
capabilities (CCβs) were between 4.2 and 34 μg/kg. The
method was successfully applied to screening of real samples obtained
from local feed markets and confirmation of the suspected target analytes.
It provides a high-throughput, sensitive, and reliable screening,
identification, and quantification of banned veterinary drugs in routine
monitoring programs of feedstuffs
Oxidation-Sulfidation Approach for Vertically Growing MoS<sub>2</sub> Nanofilms Catalysts on Molybdenum Foils as Efficient HER Catalysts
Molybdenum
disulfide (MoS<sub>2</sub>) has emerged as a promising
electrocatalyst for hydrogen evolution reaction (HER). However, the
performance of the catalyst suffers from the scarce active sites and
poor electrical conductivity. Here we grow vertical MoS<sub>2</sub> films on Mo foils to achieve highly catalytic active sites and enhanced
electrical conductivity for facilitating high efficient HER catalysis.
The ultrathin nanofilm with a thickness of around 4 nm on molybdenum
foils is grown by a two-step method: (1) the molybdenum oxide (MoO<sub>2</sub>) nanofilm is achieved by oxidizing the surface of the Mo
foil under a low pressure condition and (2) a MoS<sub>2</sub> nanofilm
is obtained by sulfurizing the MoO<sub>2</sub> nanofilm in sulfur
vapor at 700 °C within 1 min. Furthermore, the vertically aligned
MoS<sub>2</sub> nanofilm on Mo foils exhibit excellent stability in
acidic solution and the electrochemical measurements show an onset
overpotential of as low as 18 mV and a small Tafel slope of 55 mV/dec.
The excellent HER catalysis originates from the synergistic effect
of the dense catalytic active sites at the vertical MoS<sub>2</sub> surface and superior electron transport along the Mo foil. This
study opens a novel avenue for the development of earth-abundant,
low-cost electrocatalysts with high HER activities