64 research outputs found

    In situ measurements and thermo-mechanical simulation of Ti–6Al–4V laser solid forming processes

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    Residual stresses and distortions are two technical obstacles for popularizing the additive manufacturing (AM) technology. The evolution of the stresses in AM components during the thermal cycles of the metal depositing process is not yet clear, and more accurate in situ measurements are necessary to calibrate and validate the numerical tools developed for its simulation. In this work a fully coupled thermo-mechanical analysis to simulate the laser solid forming (LSF) process is carried out. At the same time, an exhaustive experimental campaign is launched to measure the temperature evolution at different locations, as well as the distortions and both the stress and strain fields. The thermal and mechanical responses of single-wall coupons under different process parameters are recorded and compared with the numerical models. Good agreement between the numerical results and the experimental measurements is obtained. Sensitivity analysis demonstrates that the AM process is significantly affected by the laser power and the feeding rate, while poorly influenced by the scanning speed.Peer ReviewedPostprint (author's final draft

    Finite element analysis and experimental validation of the thermomechanical behavior in laser solid forming of Ti-6Al-4V

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    A three-dimensional (3D) thermomechanical coupled model for Laser Solid Forming (LSF) of Ti-6Al-4V alloy has been calibrated through experiments of 40-layers metal deposition using different scanning strategies. The sensitivity analysis of the mechanical parameters shows that the thermal expansion coefficient as well as the elastic limit of Ti-6Al-4V have a great impact on the mechanical behavior. Using the validated model and optimal mechanical parameters, the evolution of thermo-mechanical fields in LSF has been analyzed. It has been found that the stresses and distortions develop in two stages, after the deposition of the first layer and during the cooling phase after the manufacturing of the component. The cooling phase is the responsible of 70% of the residual stresses and 60% of the total distortions. The analyses indicate that by controlling the initial substrate temperature (pre-heating phase) and the final cooling phase it is possible to mitigate both distortion and residual stresses. Hence, the influence of different pre-heating procedures on the mechanical fields has been analyzed. The results show that increasing the pre-heating temperature of the substrate is the most effective way to reduce the distortions and residual stresses in Additive Manufacturing

    In situ measurements and thermo-mechanical simulation of Ti–6Al–4V laser solid forming processes

    Get PDF
    Residual stresses and distortions are two technical obstacles for popularizing the additive manufacturing (AM) technology. The evolution of the stresses in AM components during the thermal cycles of the metal depositing process is not yet clear, and more accurate in situ measurements are necessary to calibrate and validate the numerical tools developed for its simulation. In this work a fully coupled thermo-mechanical analysis to simulate the laser solid forming (LSF) process is carried out. At the same time, an exhaustive experimental campaign is launched to measure the temperature evolution at different locations, as well as the distortions and both the stress and strain fields. The thermal and mechanical responses of single-wall coupons under different process parameters are recorded and compared with the numerical models. Good agreement between the numerical results and the experimental measurements is obtained. Sensitivity analysis demonstrates that the AM process is significantly affected by the laser power and the feeding rate, while poorly influenced by the scanning speed

    The gut microbiome dysbiosis and regulation by fecal microbiota transplantation: umbrella review

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    BackgroundGut microbiome dysbiosis has been implicated in various gastrointestinal and extra-gastrointestinal diseases, but evidence on the efficacy and safety of fecal microbiota transplantation (FMT) for therapeutic indications remains unclear.MethodsThe gutMDisorder database was used to summarize the associations between gut microbiome dysbiosis and diseases. We performed an umbrella review of published meta-analyses to determine the evidence synthesis on the efficacy and safety of FMT in treating various diseases. Our study was registered in PROSPERO (CRD42022301226).ResultsGut microbiome dysbiosis was associated with 117 gastrointestinal and extra-gastrointestinal. Colorectal cancer was associated with 92 dysbiosis. Dysbiosis involving Firmicutes (phylum) was associated with 34 diseases. We identified 62 published meta-analyses of FMT. FMT was found to be effective for 13 diseases, with a 95.56% cure rate (95% CI: 93.88–97.05%) for recurrent Chloridoids difficile infection (rCDI). Evidence was high quality for rCDI and moderate to high quality for ulcerative colitis and Crohn’s disease but low to very low quality for other diseases.ConclusionGut microbiome dysbiosis may be implicated in numerous diseases. Substantial evidence suggests FMT improves clinical outcomes for certain indications, but evidence quality varies greatly depending on the specific indication, route of administration, frequency of instillation, fecal preparation, and donor type. This variability should inform clinical, policy, and implementation decisions regarding FMT

    Host-country headquarters and an MNE's subsequent within-country diversifications

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    We propose that the establishment of a host-country headquarters (HCHQ) in a large emerging market can be viewed as part of a multinational enterprise's (MNE) political strategy to facilitate its within-country diversifications by reducing institutional intervention of the host government. Using a sample of MNEs in China in the period 1979–2005, we find that MNEs with an HCHQ had a greater number of subsequent diversifications in China, as compared with those MNEs without an HCHQ. This effect was more prominent when the diversifications were in domains with a higher level of institutional intervention.
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