Archaeological Soybean (Glycine max) in East Asia: Does Size Matter?

The recently acquired archaeological record for soybean from Japan, China and Korea is shedding light on the context in which this important economic plant became associated with people and was domesticated. This paper examines archaeological (charred) soybean seed size variation to determine what insight can be gained from a comprehensive comparison of 949 specimens from 22 sites. Seed length alone appears to represent seed size change through time, although the length×width×thickness product has the potential to provide better size change resolution. A widespread early association of small seeded soybean is as old as 9000–8600 cal BP in northern China and 7000 cal BP in Japan. Direct AMS radiocarbon dates on charred soybean seeds indicate selection resulted in large seed sizes in Japan by 5000 cal BP (Middle Jomon) and in Korea by 3000 cal BP (Early Mumun). Soybean seeds recovered in China from the Shang through Han periods are similar in length to the large Korean and Japanese specimens, but the overall size of the large Middle and Late Jomon, Early Mumun through Three Kingdom seeds is significantly larger than any of the Chinese specimens. The archaeological record appears to disconfirm the hypothesis of a single domestication of soybean and supports the view informed by recent phyologenetic research that soybean was domesticated in several locations in East Asia

Co-reductive fabrication of carbon nanodots with high quantum yield for bioimaging of bacteria

A simple and straightforward synthetic approach for carbon nanodots (C-dots) is proposed. The strategy is based on a one-step hydrothermal chemical reduction with thiourea and urea, leading to high quantum yield C-dots. The obtained C-dots are well-dispersed with a uniform size and a graphite-like structure. A synergistic reduction mechanism was investigated using Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The findings show that using both thiourea and urea during the one-pot synthesis enhances the luminescence of the generated C-dots. Moreover, the prepared C-dots have a high distribution of functional groups on their surface. In this work, C-dots proved to be a suitable nanomaterial for imaging of bacteria and exhibit potential for application in bioimaging thanks to their low cytotoxicity

Absorption and Transport Characteristics and Mechanisms of Carnosic Acid

Carnosic acid (CA) is a phenolic diterpenoid mainly found in rosemary and sage. CA has been reported to possess health-beneficial effects in various experimental settings. Herein, a mouse experiment and Caco-2 single-cell model were used to understand the absorption and transport characteristics of CA. First, we determined the tissue distribution of CA in mice, following an oral gavage at a physiologically relevant dose. We found that CA was bioavailable systemically and present locally in the digestive tract, especially in the cecum and colon. Next, we thought to characterize the absorption and transport of CA in the Caco-2 cell monolayer model of the intestinal epithelial barrier. In the Caco-2 cell model, CA exhibited a moderate permeability and was subjected to a mild efflux. Moreover, the apparent permeability coefficient (Papp) of CA transported across Caco-2 cell monolayers was significantly changed when the inhibitors of specific active transporter and passive diffusion were added to cells, suggesting that the absorption and transport of CA involved both passive and active transportation. The present study is an important first step towards understanding the absorption, transport, and metabolic mechanisms of CA. This could provide the scientific basis for developing CA-containing functional foods or dietary supplements with improved bioavailability

Vector optimization: set-valued and variational analysis

This book is devoted to vector or multiple criteria approaches in optimization. Topics covered include: vector optimization, vector variational inequalities, vector variational principles, vector minmax inequalities and vector equilibrium problems. In particular, problems with variable ordering relations and set-valued mappings are treated. The nonlinear scalarization method is extensively used throughout the book to deal with various vector-related problems. The results presented are original and should be interesting to researchers and graduates in applied mathematics and operations researc

Efficacy of warming needle moxibustion in the treatment of ankylosing spondylitis: A protocol of a randomized controlled trial

Background: Ankylosing spondylitis is a recurrent autoimmune disease, which has a high disability rate and seriously affects patients' daily life. Conventional treatment cannot effectively solve the clinical problems of patients, and long-term medication is accompanied by adverse reactions. The evidence shows that warming needle moxibustion has advantages in the treatment of ankylosing spondylitis, but there is still a lack of clinical studies on warm acupuncture alone and long-term follow-up. Methods: This is a prospective randomized controlled trial to study the efficacy and safety of needle warming through moxibustion in the treatment of ankylosing spondylitis. It was approved by the Ethics Committee of Clinical Research of our hospital. Patients were randomly assigned to an observation group or a control group. The patients were followed up for 6 months after 30 days of treatment. Observation indicators include：Activity Index、Functional Ability、BASMI、Inflammatory indicators、Adverse reactions and so on. Finally, SPASS 22.0 software is used for statistical analysis of the data. Discussion: This study will evaluate the clinical efficacy of warming needle moxibustion in the treatment of ankylosing spondylitis. The results of this study will provide a reference basis for the clinical use of warm needle moxibustion in the treatment of ankylosing spondylitis

Patterns of spread and adoption of millet agriculture along the Eastern Rim of the Tibetan Plateau: archaeobotanical evidence from Houzidong, Southwest China (4200-4000 Cal. BP)

The spread of domesticated crops has commonly occurred alongside broad patterns of long- and short-distance human movements and culture contact across regions. While exchange across Eurasia along the so-called Silk Road has been much discussed, recent work has revealed increasingly more evidence for early north-south contact along the eastern rim of the Tibetan Plateau. Main points of debate concern the timing and direction of the spread of agriculture and domesticated crops. This paper contributes to these discussions by presenting new data from macrobotanical remains and phytoliths from Houzidong in southwest Sichuan, a Neolithic site on the eastern rim of the Tibetan Plateau. The results show that the main crops during the late Neolithic (4200-4000 cal. BP) were foxtail millet (Setaria italica) and broomcorn millet (Panicum miliaceum), with a small amount of rice (Oryza sativa), but that agriculture was overall not a major focus. Rather, the subsistence at Houzidong like at other sites in the region was highly diverse, relying on gathering, hunting, and small-scale cultivation with considerable crop diversity aimed at minimizing the impact of potential crop failure. This paper shows that subsistence practices differed markedly between sites, local populations exploiting the rich natural resources in the respective ecological niches in various ways. We argue that the wide variety of food sources available in southwest China allowed people to mitigate risk but also made them more receptive to new food sources such as plant crops, experimenting with them and adding them to their portfolio. Similar patterns can be seen in the adoption and adaptation of other outside influences with each community picking and choosing what suited them best, thus creating the rich and varied patchwork of highly localized cultural phenomena that came to characterize southwest China

Thifluzamide, Fludioxonil, and Clothianidin as Seed Treatment Can Efficiently Control Major Soil-Borne Diseases, Aphids (Aphidoidea spp.), and Residue Distribution in the Field

Combined seed treatment with neonicotinoids and fungicides offers a potential control measure for pest management at the wheat seeding stage. In this study, a novel, highly-efficient seed-coating agent was prepared using thifluzamide, fludioxonil, and clothianidin as its active components and other additives (abbreviated to TFC). Laboratory experiments and field trials revealed a positive effect on germination, plant height, and root length, with 90% control efficiency on wheat sharp eyespots and aphid infestations. Meanwhile, the distribution of thifluzamide, fludioxonil, and clothianidin residues in the wheat plants at harvest was below 0.05 mg/kg both at the recommended dosage and at 2.0 times the recommended dose. Furthermore, an artificial soil assay of biotoxicity in earthworms revealed a low level of toxicity at LC50 > 10 mg/kg. Overall, these findings suggest that TFC has the potential to control major soil-borne diseases and pest infestations in wheat, offering an environmentally-friendly alternative to more toxic pesticides

Modulating Chlorination Position on Polymer Donors for Highly Efficient Nonfullerene Organic Solar Cells

Introducing substituent groups has been regarded as an effective method to construct highly efficient polymer donors. However, the correlation between the position of substituent groups and the device performance of polymer donors has rarely been carefully studied and compared. Herein, Cl atoms are introduced into the BDT-based thienyl side chains and BDD-based thienyl pi-bridges to obtain two chlorinated donor-acceptor (D-A) polymer donors H1 and H2, respectively. By systematically comparing the photovoltaic properties of H1 and H2, it is found that the device performance of polymer donors is sensitive to the position of chlorine atoms. The nonfullerene organic solar cells (OSCs) based on H1:IT-4F and H1:Y6 display a superior power conversion efficiency (PCE) of 12.34 and 15.62%, whereas the PCE of H2:IT-4F and H2:Y6 is 11.04 and 13.80%. As the H1-based blend shows more desirable aggregation morphology, more preferential face-on orientation, and more efficient extraction dissociation occurs. The current work demonstrates that the position of chlorine substitution can be reasonably optimized for state-of-the-art polymer donors in the highly efficient nonfullerene OSCs