1 research outputs found
In Vivo Biosynthesized Zinc and Iron Oxide Nanoclusters for High Spatiotemporal Dual-Modality Bioimaging of Alzheimer’s Disease
Alzheimer’s disease is still
incurable and neurodegenerative, and there is a lack of detection
methods with high sensitivity and specificity. In this study, by taking
different month old Alzheimer’s mice as models, we have explored
the possibility of the target bioimaging of diseased sites through
the initial injection of zinc gluconate solution into Alzheimer’s
model mice post-tail vein and then the combination of another injection
of ferrous chloride (FeCl<sub>2</sub>) solution into the same Alzheimer’s
model mice post-stomach. Our observations indicate that both zinc
gluconate solution and FeCl<sub>2</sub> solution could cross the blood–brain
barrier (BBB) to biosynthesize the fluorescent zinc oxide nanoclusters
and magnetic iron oxide nanoclusters, respectively, in the lesion
areas of the AD model mice, thus enabling high spatiotemporal dual-modality
bioimaging (i.e., including fluorescence bioimaging (FL) and magnetic
resonance imaging (MRI)) of Alzheimer’s disease for the first
time. The result presents a novel promising strategy for the rapid
and early diagnosis of Alzheimer’s disease