Harnessing the Reactivity of Iridium Hydrides by Air: Iridium-Catalyzed Oxidation of Aldehydes to Acids in Water

An iridium-catalyzed oxidation of aldehydes to acids was realized by using air as the oxidant and water as the solvent in the presence of base. Interestingly, the same type of catalysts were also used for the reduction of aldehydes under acidic conditions. A common iridium hydride intermediate is proposed for both redox reactions. The oxidation has a number of advantages such as high yields, great functionality tolerance, and easy purification without chromatography

KEGG pathway analysis of genes highly correlated with <i>Myl3</i> at d35 in wild-type vs. MSTN-null mice.

<p>KEGG pathway analysis of genes highly correlated with <i>Myl3</i> at d35 in wild-type vs. MSTN-null mice.</p

Top 20 PIF at d35^*.

<p>*The top 20 PIF scores with a q-value < 0.10 are presented. For multiple probesetIDs with the same annotation, the probesetID with smallest q-value was saved.</p><p>Top 20 PIF at d35^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0117607#t009fn001" target="_blank">*</a>}.</p

Top 20 WT/null differentially expressed genes ranked by significance at d35, q < 0.05^*.

<p>*For multiple probesetIDs with the same annotation, the probesetID with smallest q-value was saved.</p><p>^{^}Fold changes are presented as WT/null. Fold change > 1 indicates higher expression in the WT compared to the null. Fold change < 1 indicates higher expression in the null genotype compared to the WT.</p><p>Top 20 WT/null differentially expressed genes ranked by significance at d35, q < 0.05^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0117607#t002fn001" target="_blank">*</a>}.</p

Over-represented motifs in genes upregulated in WT at 13.5 d.p.c.

<p>Over-represented motifs in genes upregulated in WT at 13.5 d.p.c.</p

Over-represented motifs in genes upregulated in MSTN-null at 13.5 d.p.c.

<p>Over-represented motifs in genes upregulated in MSTN-null at 13.5 d.p.c.</p

Top 20 PIF at 13.5 d.p.c.

<p>* The top 20 PIF scores with a q-value < 0.10 are presented. For multiple probesetIDs with the same annotation, the probesetID with smallest q-value was saved.</p><p>^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0117607#t008fn001" target="_blank">*</a>}</p

Differential wiring of co-correlated genes between WT and MSTN-null mice (|r| ≥ 0.9).

<p>Differential wiring of co-correlated genes between WT and MSTN-null mice (|r| ≥ 0.9).</p

Top 10 RIF2 (wild type minus null) at d35.

<p>Top 10 RIF2 (wild type minus null) at d35.</p

Top 20 WT/null differentially expressed genes ranked by significance at 13.5 d.p.c., q < 0.05^*.

<p>*For multiple probesetIDs with the same annotation, the probesetID with smallest q-value was saved.</p><p>^{^}Fold changes are presented as WT/null. Fold change > 1 indicates higher expression in the WT compared to the null. Fold change < 1 indicates higher expression in the null genotype compared to the WT.</p><p>Top 20 WT/null differentially expressed genes ranked by significance at 13.5 d.p.c., q < 0.05^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0117607#t001fn001" target="_blank">*</a>}.</p