Forest plots of HR and 95%CI for disease-free survival / progress-free survival in ovarian cancer according to presence of HER2.

<p>Random-effects model was used.</p

Effect of vitamin E supplementation on uterine cervical neoplasm: A meta-analysis of case-control studies

<div><p>Several epidemiological studies have suggested that vitamin E could reduce the risk of uterine cervical neoplasm. However, controversial data were presented by different reports. Hence, we conducted a meta-analysis to assess the relationship between vitamin E and the risk of cervical neoplasia. We performed a comprehensive search of the PubMed, Embase and Cochrane databases through December 31, 2016. Based on a fixed-effects or random-effects model, the odds ratio (OR) and 95% confidence intervals (CIs) were calculated to assess the combined risk. Subgroup analyses and meta-regression were done to assess the source of heterogeneity. Subgroup analyses were performed according to survey ways, types of cervical neoplasia, study populations. A protocol was registered with PROSPERO (No. CRD42016036672). In total, 15 case-control studies were included, involving 3741 cases and 6328 controls. Our study suggested that higher category of vitamin E could reduce the cervical neoplasia risk (OR = 0.58, 95% CIs = 0.47–0.72, <i>I</i>² = 83%). In subgroup-analysis, both vitamin E intake and blood levels of vitamin E had a significant inverse association with the risk of cervical neoplasm. Additionally, we found the same relationship between vitamin E and cervical neoplasia among different populations and types of cervical neoplasia. Meta-regression showed that none of the including covariates were significantly related to the outcomes. No evidence of publication bias was observed. In conclusion, vitamin E intake and blood vitamin E levels were inversely associated with the risk of cervical neoplasia.</p></div

Forest plots of HR and 95%CI for disease-free survival / progress-free survival in ovarian cancer according to presence of HER2.

<p>Random-effects model was used.</p

Subgroup analysis of vitamin E and different types of cervical neoplasia.

<p>Subgroup analysis of vitamin E and different types of cervical neoplasia.</p

The prognostic value of HER2 in ovarian cancer: A meta-analysis of observational studies - Fig 6

<p><b>6A.</b> Begg’s publication bias plot of the studies assessing HER2 expression and overall survival in ovarian cancer. <b>6B.</b> Begg’s publication bias plot of the studies assessing HER2 expression and disease-free survival / progress-free survival in ovarian cancer. Visual inspection of the funnel plot did not identify substantial asymmetry.</p

Subgroup analysis of vitamin E and cervical neoplasia in different populations.

<p>Subgroup analysis of vitamin E and cervical neoplasia in different populations.</p

Forest plots of HR and 95%CI for overall survival in ovarian cancer according to presence of HER2.

<p>Random-effects model was used.</p

The forest plot between highest versus lowest categories of vitamin E and cervical cancer.

<p>The forest plot between highest versus lowest categories of vitamin E and cervical cancer.</p

Subgroup analyses of the relationship between HER2 expression and disease-free survival / progress-free survival of ovarian cancer.

<p>Subgroup analyses of the relationship between HER2 expression and disease-free survival / progress-free survival of ovarian cancer.</p

The prognostic value of HER2 in ovarian cancer: A meta-analysis of observational studies - Fig 7

<p><b>7A.</b> Sensitivity analysis of 34 studies included in this meta-analysis for overall survival. <b>7B.</b> Sensitivity analysis of 14 studies included in this meta-analysis for disease-free survival / progress-free survival. Leave-one-out method was used to confirm the stability of the results.</p