硫酸塩含有低濃度産業廃水のUASB処理およびバイオガス生成に関する研究

要約のみTohoku University李玉友課

MiR-214 promotes renal fibrosis in diabetic nephropathy via targeting SOCS1

Purpose: To elucidate how miR-214 regulates the pathogenesis of diabetic nephropathy (DN). Methods: The extent of fibrosis in DN mice kidneys was examined using Masson’s staining. Quantitative polymerase chain reaction (qPCR) was used to determine the levels of miR-214. Dual luciferase reporter assay was used to identify the target of miR-214. The expression of fibrosis marker proteins of high glucose-stimulated NRK-52E cells transfected with miR-214 was determined using western blotting. Results: Fibrosis in renal tissue of DN mice was significantly increased and miR-214 was upregulated (p < 0.001). Suppressor of cytokine signaling 1 protein (SOCS1) was the target gene of miR-214, and overexpression of miR-214 promoted fibrosis (p < 0.05, p < 0.001). On the other hand, overexpression of SOCS1 inhibited this process, indicating that miR-214 promoted fibrosis via targeting SOCS1 (p < 0.001). Finally, inhibition of miR-214 c ameliorated renal fibrosis in DN mice (p < 0.01, p < 0.001). Conclusions: MiR-214 is upregulated in db/db DN mice kidney tissue; miR-214 regulates renal fibrosis in DN mice by targeting SOCS1

Spin-dependent localization of helical edge states in a non-Hermitian phononic crystal

As a distinctive feature unique to non-Hermitian systems, non-Hermitian skin effect displays fruitful exotic phenomena in one or higher dimensions, especially when conventional topological phases are involved. Among them, hybrid skin-topological effect is theoretically proposed recently, which exhibits anomalous localization of topological boundary states at lower-dimensional boundaries accompanied by extended bulk states. Here we experimentally realize the hybrid skin-topological effect in a non-Hermitian phononic crystal. The phononic crystal, before tuning to be non-Hermitian, is an ideal acoustic realization of the Kane-Mele model, which hosts gapless helical edge states at the boundaries. By introducing a staggered distribution of loss, the spin-dependent edge modes pile up to opposite corners, leading to a direct observation of the spin-dependent hybrid skin-topological effect. Our work highlights the interplay between topology and non-Hermiticity and opens new routes to non-Hermitian wave manipulations