Rapid and global identification of potentially bioactive Crude Eextracts from chinese medicinal formula Chuanbeipipa dropping pills

A dichloromethane extract (DME) of the traditional Chinese medicine Chuanbeipipa dropping pill (CBPP) was obtained. The main bioactive components of the DME were identified and analysed by ultra-performance liquid chromatography/electrospray ionisation quadrupole time-of-flight tandem mass spectrometry. The retention time, mass spectrum, and tandem mass spectrum of the DME were compared with those of reference standards as well as literature data, and fifty-five components were resolved. Fourteen components were confirmed to have effects on cough and asthma. The current study aimed to establish a reliable and effective method for screening the potentially bioactive components of CBPP, report for the first time the basis of CBPP pharmacology, and provide useful information for further studies on the CBPP mechanism of action.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Diversities of disability caused by lung cancer in the 66 Belt and Road initiative countries: a secondary analysis from the Global Burden of Disease Study 2019

ObjectivesDue to the increase in life expectancy and the aging of the global population, the “Belt and Road” (“B&R”) countries are faced with varying degrees of lung cancer threat. The purpose of this study is to analyze the differences in the burden and trend of lung cancer disability in the “B&R” countries from 1990 to 2019 so as to provide an analytical strategic basis to build a healthy “B&R”.MethodsData were derived from the Global Burden of Disease 2019 (GBD 2019). Incidence, mortality, prevalence, the years lived with disability (YLDs), and disability-adjusted life years (DALYs) of lung cancer and those attributable to different risk factors were measured from 1990 to 2019. Trends of disease burden were estimated by using the average annual percent change (AAPC), and the 95% uncertainty interval (UI) was reported.ResultsChina, India, and the Russian Federation were the three countries with the highest burden of lung cancer in 2019. From 1990 to 2019, the AAPC of incidence, prevalence, mortality, and DALYs generally showed a downward trend in Central Asia (except Georgia) and Eastern Europe, while in China, South Asia (except Bangladesh), most countries in North Africa, and the Middle East, the trend was mainly upward. The AAPC of age-standardized incidence was 1.33% (1.15%–1.50%); the AAPC of prevalence, mortality, and DALYs from lung cancer in China increased by 24% (2.10%–2.38%), 0.94% (0.74%–1.14%), and 0.42% (0.25%–0.59%), respectively. A downward trend of the AAPC values of age-standardized YLD rate in men was shown in the vast majority of “B&R” countries, but for women, most countries had an upward trend. For adults aged 75 years or older, the age-standardized YLD rate showed an increasing trend in most of the “B&R” countries. Except for the DALY rate of lung cancer attributable to metabolic risks, a downward trend of the DALY rate attributable to all risk factors, behavioral risks, and environmental/occupational risks was shown in the vast majority of “B&R” countries.ConclusionThe burden of lung cancer in “B&R” countries varied significantly between regions, genders, and risk factors. Strengthening health cooperation among the “B&R” countries will help to jointly build a community with a shared future for mankind

The socio-spatial design of community and governance: Interdisciplinary urban design in China

This book proposes a new interdisciplinary understanding of urban design in China based on a study of the transformative effects of socio-spatial design and planning on communities and their governance. This is framed by an examination of the social projects, spaces, and realities that have shaped three contexts critical to the understanding of urban design problems in China: the histories of “collective forms” and “collective spaces”, such as that of the urban danwei (work-unit), which inform current community building and planning; socio-spatial changes in urban and rural development; and disparate practices of “spatialised governmentality”. These contexts and an attendant transformation from planning to design and from government to governance, define the current urban design challenges found in the dominant urban xiaoqu (small district) and shequ (community) development model. Examining the histories, transformations, and practices that have shaped socio-spatial epistemologies and experiences in China – including a specific sense of community and place that is rather based on a concrete “collective” than abstract “public” space and underpinned by socialised governance – this book brings together a diverse range of observations, thoughts, analyses, and projects by urban researchers and practitioners. Thereby discussing emerging interdisciplinary urban design practices in China, this book offers a valuable resource for all academics, practitioners, and stakeholders with an interest in socio-spatial design and development

Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling

Although melanoma is initiated by acquisition of point mutations and limited focal copy number alterations in melanocytes-of-origin, the nature of genetic changes that characterise lethal metastatic disease is poorly understood. Here, we analyze the evolution of human melanoma progressing from early to late disease in 13 patients by sampling their tumours at multiple sites and times. Whole exome and genome sequencing data from 88 tumour samples reveals only limited gain of point mutations generally, with net mutational loss in some metastases. In contrast, melanoma evolution is dominated by whole genome doubling and large-scale aneuploidy, in which widespread loss of heterozygosity sculpts the burden of point mutations, neoantigens and structural variants even in treatment-naïve and primary cutaneous melanomas in some patients. These results imply that dysregulation of genomic integrity is a key driver of selective clonal advantage during melanoma progression

Determination of Long Horizontal Borehole Height in Roofs and Its Application to Gas Drainage

Accurately determining the height of the gas-guiding fracture zone in the overlying strata of the goaf is the key to find the height of the long horizontal borehole in the roof. In order to determine the height, in this study we chose the 6306 working face of Tangkou Coal Mine in China as a research example and used both the theoretical model and discrete element method (DEM) numerical simulation to find the height of the gas-guiding fracture zone and applied the height to drill a long horizontal borehole in the roof of the 6303 working face. Furthermore, the borehole was utilized to deep into the roof for coalbed methane drainage and the results were compared with conventional gas drainage measures from other aspects. The height of the gas-guiding fracture zone was found to be 48.57 m in theoretical model based on the bulk coefficient and the void ratio and to be 51.19 m in the DEM numerical simulation according to the temporal and spatial variation characteristics of porosity. Taking both the results of theoretical analysis and numerical simulation into consideration, we determined that gas-guiding fracture zone is 49.88 m high and applied it to drill a long horizontal borehole deep into the roof in the 6303 working face field. Compared with conventional gas drainage measures, we found that the long horizontal borehole has the high stability, high efficiency and strong adaptability for methane drainage

Fluid interface moving for the concurrent production of gas cap and oil ring of gas cap reservoirs

The pressure balance between gas cap and oil ring is likely to be broken during their concurrent production in gas cap reservoirs. In order to increase the whole development efficiency of the concurrent production of gas cap and oil ring, the Zhanzhol gas cap reservoir of Kazakhstan was taken as example to carry out the research, a three-dimensional visualization physical model was established based on the similarity criterion of oil phase, gas phase and water phase, and a reservoir engineering model of fluid interface moving rate was also set up according to the material balance principle. The calculation results of reservoir engineering model tally with the results of physical simulation experiment and reservoir dynamic test data. The moving rate template of fluid interface under three development modes, depletion development, barrier water injection development and barrier plus pattern water injection development have been also established by reservoir engineering method. The main controlling factors under different development modes have been figured out: for depletion development, the main controlling factors on the stabilization of oil-gas contact are oil recovery rate and gas recovery rate; for barrier water injection development, the main controlling factors are oil recovery rate, gas recovery rate and production-injection ratio; and for barrier plus pattern water injection development, the main controlling factors are oil recovery rate, gas recovery rate, production-injection ratio and the ratio of barrier water injection to pattern water injection. Key words: Zhanzhol oil field, gas cap reservoir, concurrent production of gas cap and oil ring, fluid interface, moving rul