Quantification of the staining intensity for E-cadherin, ZO-1 and occludin in control and mature CRSwNP.

<p>Quantification of the staining intensity for E-cadherin, ZO-1 and occludin in control and mature CRSwNP.</p

Epithelial loss (%) in control, mature CRSwNP and middle turbinate CRSwNP.

<p>MT, middle turbinate.</p

Immunostaining of celluar and extracelluar components.

<p>HE (A1-A5), CD68 (B1-B5),MMR (C1-C5), α-SMA (D1-D5), vimentin (E1-E5), pSmad2 (F1-F5), Fn (G1-G5) picrosirius red staining viewed in bright-field (H1-H5) and viewed under polarized light (I1-I5) in mature CRSwNP (A1-G1), polyp area of middle turbinate CRSwNP (A2-G2),turbinate area of middle turbinate CRSwNP (A4-G4) and control mucosa (A5-G5)(final magnification 400×). The overview of middle turbinate CRSwNP was shown in A3-G3 (composed by Photoshop software with pictures in 40×magnification).</p

Quantification of celluar and extracelluar components.

<p>Eosinophils(A), CD68-(B), MMR-(C), α-SMA-(D), vimentin-(E), and pSmad2(F) positive cells, Fn (G) and collagen(H) in control interior turbinates (control IT), mature CRSwNP and middle turbinate CRSwNP, separated into turbinate and polyp areas. </p

Fn mRNA expression and Fn protein concentration.

<p>Fn mRNA expression and Fn protein concentration.</p

Immunostaining of E-cadherin, ZO-1 and occludin in control and mature CRSwNP.

<p>E-cadherin (A, B), ZO-1(C, D), occludin (E, F) for control (A, C, E) and mature CRSwNP (B, D, F).Original magnification 400x.</p

Diagram of middle turbinate polyps in patients with CRSwNP.

<p>As the diagram shows, for the samples of middle turbinate CRSwNP, special attention was paid to the collection of the whole polyp with the stalk and parts of the surrounding mucosa. This allowed us to discriminate into polyp area and turbinate area for analysis.</p