DataSheet1_Association of the Clínica Universidad de Navarra-Body Adiposity Estimator With Type 2 Diabetes: A Retrospective Cohort Study.docx

Objectives: Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) is considered to be a more accurate indicator of body fat estimation. We aimed to investigate the association of CUN-BAE with the risk of type 2 diabetes mellitus (T2DM) and to compare the strength of the association between CUN-BAE, body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) and T2DM.Methods: The data were obtained from the annual health checkup database of residents in Xinzheng, China. From January 2011 to December 2021, 80,555 subjects aged ≥45 years met the inclusion criteria. Cox proportional hazard regression models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for CUN-BAE, BMI, WC, and WHtR in T2DM.Results: During a mean follow-up of 6.26 years, T2DM occurred in 12,967 subjects. The multivariable-adjusted HRs (95% CIs) of T2DM (highest vs. reference group) were 1.994 (1.811–2.196) for CUN-BAE, 1.751 (1.665–1.842) for WC, 1.715 (1.631–1.804) for WHtR, and 1.510 (1.436–1.588) for BMI, respectively. In addition, the risk of T2DM increased with baseline CUN-BAE (HR: 1.374; 95% CI: 1.328, 1.421), WC (HR: 1.236; 95% CI: 1.215, 1.256), WHtR (HR: 1.228; 95% CI: 1.208, 1.248), and BMI (HR: 1.175; 95% CI: 1.156, 1.195).Conclusion: Compared to BMI, WC or WHtR, CUN-BAE may more adequately reflect the adverse effects of adiposity on the risk of T2DM.</p

Highly Controllable and Efficient Synthesis of Mixed-Halide CsPbX₃ (X = Cl, Br, I) Perovskite QDs toward the Tunability of Entire Visible Light

CsPbX₃ (X = Cl, Br, I) perovskite quantum dots (PQDs) have been intensively investigated on photoelectric devices due to their superior optical properties. To date, the stability of CsPbX₃ PQDs is still an open challenge. The previous mixed-halide CsPbX₃ PQDs were generally obtained via the anion-exchange method at 40 °C. Here, the single- and mixed-halide CsPbX₃ PQDs are synthesized at high temperature via the hot injection technique. The surface ligands could thus be strongly coordinated onto the surface of the PQDs, which dramatically improve the optical properties of the PQDs. The resulting CsPbX₃ PQDs have high quantum yield (QY, 40–95%), narrow full width at half-maximum (FWHM) (the narrowest FWHM <10 nm), tunable band gap (408–694 nm), and highly strong photostability. The variation of their emission peaks upon anion atoms is well-supported by the theoretical band gaps calculated by the density functional theory calculations with the alloy formula correction. Hence, these PQDs show great potential as good candidates for photoelectric devices

Mean clustering coefficients (Cp) and mean absolute path lengths (Lp) in APOE <i>ε</i>4 carriers and APOE <i>ε</i>4 noncarriers.

<p>Mean clustering coefficients (Cp) and mean absolute path lengths (Lp) in APOE <i>ε</i>4 carriers and APOE <i>ε</i>4 noncarriers.</p

A. The hub regions in APOE <i>ε</i>4 carriers (The size of the circles represents the nodal centrality in this brain region).

<p>B. The hub regions in APOE <i>ε</i>4 noncarriers. C. Differences of between-group nodal centrality in the APOE <i>ε</i>4 carriers compared with the APOE <i>ε</i>4 noncarriers. The six hub regions which are at least in a network of the APOE <i>ε</i>4 carriers and the APOE <i>ε</i>4 noncarriers and these hub regions indicate the significant between-group differences(p<0.05). The blue spheres represent nodal centrality with significant decreases and the red spheres represent nodal centrality with significant increases in the APOE <i>ε</i>4 carriers compared with the APOE <i>ε</i>4 noncarriers.</p

Hub regions in metabolic networks of the APOE <i>ε</i>4 carriers and the APOE <i>ε</i>4 noncarriers listing by the descending order of the APOE <i>ε</i>4 carriers’ normalized betweenness.

<p>Hub regions in metabolic networks of the APOE <i>ε</i>4 carriers and the APOE <i>ε</i>4 noncarriers listing by the descending order of the APOE <i>ε</i>4 carriers’ normalized betweenness.</p

Abnormal interregional correlations in APOE <i>ε</i>4 carriers compared with APOE <i>ε</i>4 noncarriers.

<p>The yellow dots indicate the AAL brain regions which showed the significantly abnormal correlations. The red and blue lines indicate the significantly increased and decreased interregional correlations.</p

The FAQ scores and the average metabolism in left rolandic operculum and left superior parietal gyrus in APOE <i>ε</i>4 carriers.

<p>The FAQ scores and the average metabolism in left rolandic operculum and left superior parietal gyrus in APOE <i>ε</i>4 carriers.</p

Statistical parametric map showing a higher or lower regional cerebral metabolic rate of glucose (FDR corrected p<0.05) in APOE <i>ε</i>4 carriers compared with APOE <i>ε</i>4 noncarriers.

<p>The color bar indicates the t value. The cluster size > = 5.</p

The left image indicates the between-group differences in clustering coefficients (Cp) and the right image indicates the between-group differences in absolute path lengths (Lp).

<p>The black open circles show the average values in each property and the black lines indicate the 95% confidence intervals of the between-group differences through 1000 permutation tests in each sparsity.</p

Intravenous injection of C/EBPα-saRNA-dendrimer inhibited tumor metastasis and improved liver function in nude mice with tumors from HepG2-RFP cells.

<p>(A) Imaging of liver orthotopic xenograft tumors after injection of C/EBPα-saRNA on day 40 post-injection of HepG2-RFP cells and scramble-saRNA as the control. Higher fluorescence intensity and intrahepatic metastasis was observed in the control group. (B) C/EBPα-saRNA-dendrimer was tested for nuclease sensitivity in nude mice for indicated times. (C) Survival analysis of C/EBPα-saRNA-injected mouse groups and the control (n = 9) (log rate: 0.0167). (D) Statistical table of tumor formation, intrahepatic and distant metastasis. (E) Hematoxylin and eosin staining of liver and lung from C/EBPα-saRNA injected mice and the control. (F) Expression of C/EBPα was determined by RT-PCR and western blotting in liver tissue of mice injected with C/EBPα-saRNA-dendrimer or the control. (G-I) C/EBPα-saRNA-dendrimer injected nude mice showed significant changes in circulating levels of serum albumin (G), AST (H) and ALT (I). Data represent mean±SD.</p