141 research outputs found

    Research on the Psychological Satisfaction Mechanism of Video Platform Users’ Re-creation Behavior

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    Re-creation behavior is an important way for video website users to generate content. It can help users understand and develop themselves, improve the retention rate of platform users, and promote the emergence of new business models for video websites. Based on the uses and gratifications approach, this study proposes a research model of the psychological satisfaction process of "motivation-emotion-intention" with the re-creation video platform as the research background. Through data verification using SmartPLS, the research results show that four types of motivations, namely mimicking, helping, validation, and self-expression promote the satisfaction of lurkers' emotional needs; two types of emotions, the sense of belonging and the sense of achievement, promote lurkers to generate re-creation intentions

    Productivity and Grazing Capacity of Five Typical Natural Rangelands for Yaks in the Alpine Region of China

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    The Qinghai-Tibet plateau has greatly aroused the interest of scientists as an uncommon rangeland resource of great agro-ecological importance. Yak (Bos grunniens) is a unique, vulnerable ungulate. The objective of this experiment was to evaluate the productivity and feed value of five natural rangelands

    Geographic Patterns in the Genetic Diversity of Elymus Species From Qinghai-Tibetan and Inner Mongolian Plateau

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    The genus Elymus is the largest genus in the tribe Triticeae with about 150 species distributed in most temperate regions of the world (Dewey, 1984). The genetic diversity of Elymus spp. from alpine regions is very important for improving resistance to adverse condition. The goals of this study were to investigate micro- satellite and enzyme polymorphism and population structure of different regions and Elymus spp. in China

    Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review

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    Many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins and abnormal localization of organelles. These pathological features may be related to axonal transport deficits in neurons, which lead to failures in pathological protein targeting to specific sites for degradation and organelle transportation to designated areas needed for normal physiological functioning. Axonal transport deficits are most likely early pathological events in such diseases and gradually lead to the loss of axonal integrity and other degenerative changes. In this review, we investigated reports of mechanisms underlying the development of axonal transport deficits in a variety of common neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease and Huntington’s disease to provide new ideas for therapeutic targets that may be used early in the disease process. The mechanisms can be summarized as follows: (1) motor protein changes including expression levels and post-translational modification alteration; (2) changes in microtubules including reducing stability and disrupting tracks; (3) changes in cargoes including diminished binding to motor proteins. Future studies should determine which axonal transport defects are disease-specific and whether they are suitable therapeutic targets in neurodegenerative diseases

    Assessment of left ventricular function in patients with type 2 diabetes mellitus by non-invasive myocardial work

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    BackgroundDiabetes mellitus (DM) is a chronic disease that poses a serious risk of cardiovascular diseases. Therefore, early detection of impaired cardiac function with non-invasive myocardial imaging is critical for improving the prognosis of patients with DM.PurposeThis study aimed to assess the left ventricular (LV) function in patients with type 2 diabetes mellitus (T2DM) by non-invasive myocardial work technique.Materials and methodsIn all, 67 patients with T2DM and 28 healthy controls were included and divided into a DM group and a control group. Two-dimensional dynamic images of apical three-chamber view, apical two-chamber view, and apical four-chamber view were collected from all subjects, consisting of at least three cardiac cycles. LV myocardial strain parameters, including global longitudinal strain (GLS) and peak strain dispersion (PSD), as well as myocardial work parameters, including global constructive work (GCW), global wasted work (GWW), global work index (GWI), and global work efficiency (GWE), were obtained and analyzed.ResultsA total of 15 subjects were randomly selected to assess intra-observer and inter-observer consistency of myocardial work parameters and strain parameters, which showed excellent results (intra-class correlation coefficients: 0.856 - 0.983, P<0.001). Compared with the control group, the DM group showed significantly higher PSD (37.59 ± 17.18 ms vs. 27.72 ± 13.52 ms, P<0.05) and GWW (63.98 ± 43.63 mmHg% vs. 39.28 ± 25.67 mmHg%, P<0.05), and lower GWE (96.38 ± 2.02% vs. 97.72 ± 0.98%, P<0.001). Furthermore, the PSD was positively correlated with GWW (r = 0.565, P<0.001) and negatively correlated with GWE (r = -0.569, P<0.001).ConclusionUncoordinated LV myocardial strain, higher GWW, and lower GWE in patients with T2DM may serve as indicators for the early assessment of cardiac impairment in T2DM
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